Lack of effect of norepinephrine on cranial haemodynamics and headache in healthy volunteers

M Lindholt; K A Petersen; J F Tvedskov; Helle Klingenberg Iversen; J Olesen; P Tfelt-Hansen

doi:10.1111/j.1468-2982.2008.01739.x

Lack of effect of norepinephrine on cranial haemodynamics and headache in healthy volunteers

M Lindholt, K A Petersen, J F Tvedskov, Helle Klingenberg Iversen, J Olesen, P Tfelt-Hansen

Department of Clinical Medicine

11 Citations (Scopus)

Abstract

Stress is a provoking factor for both tension-type headache and migraine attacks. In the present single-blind study, we investigated if stress induced by norepinephrine (NE) could elicit delayed headache in 10 healthy subjects and recorded the cranial arterial responses. NE at a dose of 0.025 microg kg(-1) min(-1) or placebo was infused for 90 min and the headache was followed for 14 h. Blood flow velocity in the middle cerebral artery (measured with transcranial Doppler) and diameters of the temporal artery and the radial artery (measured with ultrasound) were followed for 2 h. There were no changes in these arterial parameters after NE. In both treatment groups three subjects developed delayed headaches. Thus, stress by NE infusion did not result in delayed headache.

Original language	English
Journal	Cephalalgia : an international journal of headache
Volume	29
Issue number	3
Pages (from-to)	384-7
Number of pages	4
ISSN	0333-1024
DOIs	https://doi.org/10.1111/j.1468-2982.2008.01739.x
Publication status	Published - Mar 2009

Keywords

Adult
Brain
Cerebrovascular Circulation
Cross-Over Studies
Epinephrine
Female
Headache
Hemodynamics
Humans
Male
Middle Cerebral Artery
Radial Artery
Single-Blind Method
Stress, Physiological
Temporal Arteries

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Cite this

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title = "Lack of effect of norepinephrine on cranial haemodynamics and headache in healthy volunteers",

abstract = "Stress is a provoking factor for both tension-type headache and migraine attacks. In the present single-blind study, we investigated if stress induced by norepinephrine (NE) could elicit delayed headache in 10 healthy subjects and recorded the cranial arterial responses. NE at a dose of 0.025 microg kg(-1) min(-1) or placebo was infused for 90 min and the headache was followed for 14 h. Blood flow velocity in the middle cerebral artery (measured with transcranial Doppler) and diameters of the temporal artery and the radial artery (measured with ultrasound) were followed for 2 h. There were no changes in these arterial parameters after NE. In both treatment groups three subjects developed delayed headaches. Thus, stress by NE infusion did not result in delayed headache.",

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AU - Lindholt, M

AU - Petersen, K A

AU - Tvedskov, J F

AU - Iversen, Helle Klingenberg

AU - Olesen, J

AU - Tfelt-Hansen, P

PY - 2009/3

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N2 - Stress is a provoking factor for both tension-type headache and migraine attacks. In the present single-blind study, we investigated if stress induced by norepinephrine (NE) could elicit delayed headache in 10 healthy subjects and recorded the cranial arterial responses. NE at a dose of 0.025 microg kg(-1) min(-1) or placebo was infused for 90 min and the headache was followed for 14 h. Blood flow velocity in the middle cerebral artery (measured with transcranial Doppler) and diameters of the temporal artery and the radial artery (measured with ultrasound) were followed for 2 h. There were no changes in these arterial parameters after NE. In both treatment groups three subjects developed delayed headaches. Thus, stress by NE infusion did not result in delayed headache.

AB - Stress is a provoking factor for both tension-type headache and migraine attacks. In the present single-blind study, we investigated if stress induced by norepinephrine (NE) could elicit delayed headache in 10 healthy subjects and recorded the cranial arterial responses. NE at a dose of 0.025 microg kg(-1) min(-1) or placebo was infused for 90 min and the headache was followed for 14 h. Blood flow velocity in the middle cerebral artery (measured with transcranial Doppler) and diameters of the temporal artery and the radial artery (measured with ultrasound) were followed for 2 h. There were no changes in these arterial parameters after NE. In both treatment groups three subjects developed delayed headaches. Thus, stress by NE infusion did not result in delayed headache.

KW - Adult

KW - Brain

KW - Cerebrovascular Circulation

KW - Cross-Over Studies

KW - Epinephrine

KW - Female

KW - Headache

KW - Hemodynamics

KW - Humans

KW - Male

KW - Middle Cerebral Artery

KW - Radial Artery

KW - Single-Blind Method

KW - Stress, Physiological

KW - Temporal Arteries

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DO - 10.1111/j.1468-2982.2008.01739.x

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JO - Cephalalgia : an international journal of headache

JF - Cephalalgia : an international journal of headache

IS - 3

ER -

Lack of effect of norepinephrine on cranial haemodynamics and headache in healthy volunteers

Abstract

Keywords

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