Lack of effect of norepinephrine on cranial haemodynamics and headache in healthy volunteers

M Lindholt; K A Petersen; J F Tvedskov; Helle Klingenberg Iversen; J Olesen; P Tfelt-Hansen

doi:10.1111/j.1468-2982.2008.01739.x

Lack of effect of norepinephrine on cranial haemodynamics and headache in healthy volunteers

M Lindholt, K A Petersen, J F Tvedskov, Helle Klingenberg Iversen, J Olesen, P Tfelt-Hansen

Institut for Klinisk Medicin

11 Citationer (Scopus)

Abstract

Stress is a provoking factor for both tension-type headache and migraine attacks. In the present single-blind study, we investigated if stress induced by norepinephrine (NE) could elicit delayed headache in 10 healthy subjects and recorded the cranial arterial responses. NE at a dose of 0.025 microg kg(-1) min(-1) or placebo was infused for 90 min and the headache was followed for 14 h. Blood flow velocity in the middle cerebral artery (measured with transcranial Doppler) and diameters of the temporal artery and the radial artery (measured with ultrasound) were followed for 2 h. There were no changes in these arterial parameters after NE. In both treatment groups three subjects developed delayed headaches. Thus, stress by NE infusion did not result in delayed headache.

Originalsprog	Engelsk
Tidsskrift	Cephalalgia : an international journal of headache
Vol/bind	29
Udgave nummer	3
Sider (fra-til)	384-7
Antal sider	4
ISSN	0333-1024
DOI	https://doi.org/10.1111/j.1468-2982.2008.01739.x
Status	Udgivet - mar. 2009

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10.1111/j.1468-2982.2008.01739.x

Citationsformater

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title = "Lack of effect of norepinephrine on cranial haemodynamics and headache in healthy volunteers",

abstract = "Stress is a provoking factor for both tension-type headache and migraine attacks. In the present single-blind study, we investigated if stress induced by norepinephrine (NE) could elicit delayed headache in 10 healthy subjects and recorded the cranial arterial responses. NE at a dose of 0.025 microg kg(-1) min(-1) or placebo was infused for 90 min and the headache was followed for 14 h. Blood flow velocity in the middle cerebral artery (measured with transcranial Doppler) and diameters of the temporal artery and the radial artery (measured with ultrasound) were followed for 2 h. There were no changes in these arterial parameters after NE. In both treatment groups three subjects developed delayed headaches. Thus, stress by NE infusion did not result in delayed headache.",

keywords = "Adult, Brain, Cerebrovascular Circulation, Cross-Over Studies, Epinephrine, Female, Headache, Hemodynamics, Humans, Male, Middle Cerebral Artery, Radial Artery, Single-Blind Method, Stress, Physiological, Temporal Arteries",

author = "M Lindholt and Petersen, {K A} and Tvedskov, {J F} and Iversen, {Helle Klingenberg} and J Olesen and P Tfelt-Hansen",

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T1 - Lack of effect of norepinephrine on cranial haemodynamics and headache in healthy volunteers

AU - Lindholt, M

AU - Petersen, K A

AU - Tvedskov, J F

AU - Iversen, Helle Klingenberg

AU - Olesen, J

AU - Tfelt-Hansen, P

PY - 2009/3

Y1 - 2009/3

N2 - Stress is a provoking factor for both tension-type headache and migraine attacks. In the present single-blind study, we investigated if stress induced by norepinephrine (NE) could elicit delayed headache in 10 healthy subjects and recorded the cranial arterial responses. NE at a dose of 0.025 microg kg(-1) min(-1) or placebo was infused for 90 min and the headache was followed for 14 h. Blood flow velocity in the middle cerebral artery (measured with transcranial Doppler) and diameters of the temporal artery and the radial artery (measured with ultrasound) were followed for 2 h. There were no changes in these arterial parameters after NE. In both treatment groups three subjects developed delayed headaches. Thus, stress by NE infusion did not result in delayed headache.

AB - Stress is a provoking factor for both tension-type headache and migraine attacks. In the present single-blind study, we investigated if stress induced by norepinephrine (NE) could elicit delayed headache in 10 healthy subjects and recorded the cranial arterial responses. NE at a dose of 0.025 microg kg(-1) min(-1) or placebo was infused for 90 min and the headache was followed for 14 h. Blood flow velocity in the middle cerebral artery (measured with transcranial Doppler) and diameters of the temporal artery and the radial artery (measured with ultrasound) were followed for 2 h. There were no changes in these arterial parameters after NE. In both treatment groups three subjects developed delayed headaches. Thus, stress by NE infusion did not result in delayed headache.

KW - Adult

KW - Brain

KW - Cerebrovascular Circulation

KW - Cross-Over Studies

KW - Epinephrine

KW - Female

KW - Headache

KW - Hemodynamics

KW - Humans

KW - Male

KW - Middle Cerebral Artery

KW - Radial Artery

KW - Single-Blind Method

KW - Stress, Physiological

KW - Temporal Arteries

U2 - 10.1111/j.1468-2982.2008.01739.x

DO - 10.1111/j.1468-2982.2008.01739.x

M3 - Journal article

C2 - 19220317

SN - 0333-1024

VL - 29

SP - 384

EP - 387

JO - Cephalalgia : an international journal of headache

JF - Cephalalgia : an international journal of headache

IS - 3

ER -

Lack of effect of norepinephrine on cranial haemodynamics and headache in healthy volunteers

Abstract

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