TY - JOUR
T1 - KV7 potassium channels
T2 - a new therapeutic target in smooth muscle disorders
AU - Stott, Jennifer B
AU - Jepps, Thomas Andrew
AU - Greenwood, Iain A
N1 - Copyright © 2013. Published by Elsevier Ltd.
PY - 2014/4
Y1 - 2014/4
N2 - Potassium channels are key regulators of smooth muscle tone, with increases in activity resulting in hyperpolarisation of the cell membrane, which acts to oppose vasoconstriction. Several potassium channels exist within smooth muscle, but the KV7 family of voltage-gated potassium channels have been identified as being crucial mediators of this process in a variety of smooth muscle. Recently, KV7 channels have been shown to be involved in the pathogenesis of hypertension, as well as being implicated in other smooth muscle disorders, providing a new and inviting target for smooth muscle disorders.
AB - Potassium channels are key regulators of smooth muscle tone, with increases in activity resulting in hyperpolarisation of the cell membrane, which acts to oppose vasoconstriction. Several potassium channels exist within smooth muscle, but the KV7 family of voltage-gated potassium channels have been identified as being crucial mediators of this process in a variety of smooth muscle. Recently, KV7 channels have been shown to be involved in the pathogenesis of hypertension, as well as being implicated in other smooth muscle disorders, providing a new and inviting target for smooth muscle disorders.
U2 - 10.1016/j.drudis.2013.12.003
DO - 10.1016/j.drudis.2013.12.003
M3 - Journal article
C2 - 24333708
SN - 1359-6446
VL - 19
SP - 413
EP - 424
JO - Drug Discovery Today
JF - Drug Discovery Today
IS - 4
ER -