Killing curve activity of ciprofloxacin is comparable to synergistic effect of beta-lactam-tobramycin combinations against Haemophilus species endocarditis strains

H Westh; N Frimodt-Møller; E Gutschik; Jette Marie Bangsborg

Killing curve activity of ciprofloxacin is comparable to synergistic effect of beta-lactam-tobramycin combinations against Haemophilus species endocarditis strains

H Westh, N Frimodt-Møller, E Gutschik, Jette Marie Bangsborg

Department of Immunology and Microbiology

4 Citations (Scopus)

Abstract

Nine Haemophilus species strains, all beta-lactamase negative, isolated from patients with endocarditis were tested in killing curve experiments. Antibiotics used were penicillin, amoxicillin, aztreonam alone and in combination with tobramycin, as well as ciprofloxacin alone. Synergism between beta-lactams and tobramycin with reduction of colony counts to zero was seen after 24 h for H. influenzae, H. parainfluenzae and H. segnis strains. Ciprofloxacin was as effective as beta-lactam-tobramycin combinations. The H. aphrophilus strain was not killed as effectively as other strains by any of the antibiotics.

Original language	English
Journal	A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica
Volume	100
Issue number	9
Pages (from-to)	856-60
Number of pages	5
ISSN	0903-4641
Publication status	Published - 1992

Keywords

Anti-Bacterial Agents
Ciprofloxacin
Drug Synergism
Endocarditis, Bacterial
Haemophilus
Humans
Microbial Sensitivity Tests
Tobramycin
beta-Lactams

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Killing curve activity of ciprofloxacin is comparable to synergistic effect of beta-lactam-tobramycin combinations against Haemophilus species endocarditis strains. / Westh, H; Frimodt-Møller, N; Gutschik, E et al.

In: A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica, Vol. 100, No. 9, 1992, p. 856-60.

Research output: Contribution to journal › Journal article › Research › peer-review

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abstract = "Nine Haemophilus species strains, all beta-lactamase negative, isolated from patients with endocarditis were tested in killing curve experiments. Antibiotics used were penicillin, amoxicillin, aztreonam alone and in combination with tobramycin, as well as ciprofloxacin alone. Synergism between beta-lactams and tobramycin with reduction of colony counts to zero was seen after 24 h for H. influenzae, H. parainfluenzae and H. segnis strains. Ciprofloxacin was as effective as beta-lactam-tobramycin combinations. The H. aphrophilus strain was not killed as effectively as other strains by any of the antibiotics.",

keywords = "Anti-Bacterial Agents, Ciprofloxacin, Drug Synergism, Endocarditis, Bacterial, Haemophilus, Humans, Microbial Sensitivity Tests, Tobramycin, beta-Lactams",

author = "H Westh and N Frimodt-M{\o}ller and E Gutschik and Bangsborg, {Jette Marie}",

year = "1992",

language = "English",

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T1 - Killing curve activity of ciprofloxacin is comparable to synergistic effect of beta-lactam-tobramycin combinations against Haemophilus species endocarditis strains

AU - Westh, H

AU - Frimodt-Møller, N

AU - Gutschik, E

AU - Bangsborg, Jette Marie

PY - 1992

Y1 - 1992

N2 - Nine Haemophilus species strains, all beta-lactamase negative, isolated from patients with endocarditis were tested in killing curve experiments. Antibiotics used were penicillin, amoxicillin, aztreonam alone and in combination with tobramycin, as well as ciprofloxacin alone. Synergism between beta-lactams and tobramycin with reduction of colony counts to zero was seen after 24 h for H. influenzae, H. parainfluenzae and H. segnis strains. Ciprofloxacin was as effective as beta-lactam-tobramycin combinations. The H. aphrophilus strain was not killed as effectively as other strains by any of the antibiotics.

AB - Nine Haemophilus species strains, all beta-lactamase negative, isolated from patients with endocarditis were tested in killing curve experiments. Antibiotics used were penicillin, amoxicillin, aztreonam alone and in combination with tobramycin, as well as ciprofloxacin alone. Synergism between beta-lactams and tobramycin with reduction of colony counts to zero was seen after 24 h for H. influenzae, H. parainfluenzae and H. segnis strains. Ciprofloxacin was as effective as beta-lactam-tobramycin combinations. The H. aphrophilus strain was not killed as effectively as other strains by any of the antibiotics.

KW - Anti-Bacterial Agents

KW - Ciprofloxacin

KW - Drug Synergism

KW - Endocarditis, Bacterial

KW - Haemophilus

KW - Humans

KW - Microbial Sensitivity Tests

KW - Tobramycin

KW - beta-Lactams

M3 - Journal article

C2 - 1389104

SN - 0903-465X

VL - 100

SP - 856

EP - 860

JO - APMIS. Supplementum

JF - APMIS. Supplementum

IS - 9

ER -

Killing curve activity of ciprofloxacin is comparable to synergistic effect of beta-lactam-tobramycin combinations against Haemophilus species endocarditis strains

Abstract

Keywords

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