Killing curve activity of ciprofloxacin is comparable to synergistic effect of beta-lactam-tobramycin combinations against Haemophilus species endocarditis strains

H Westh; N Frimodt-Møller; E Gutschik; Jette Marie Bangsborg

Killing curve activity of ciprofloxacin is comparable to synergistic effect of beta-lactam-tobramycin combinations against Haemophilus species endocarditis strains

H Westh, N Frimodt-Møller, E Gutschik, Jette Marie Bangsborg

LUKKET: Institut for Immunologi og Mikrobiologi

4 Citationer (Scopus)

Abstract

Nine Haemophilus species strains, all beta-lactamase negative, isolated from patients with endocarditis were tested in killing curve experiments. Antibiotics used were penicillin, amoxicillin, aztreonam alone and in combination with tobramycin, as well as ciprofloxacin alone. Synergism between beta-lactams and tobramycin with reduction of colony counts to zero was seen after 24 h for H. influenzae, H. parainfluenzae and H. segnis strains. Ciprofloxacin was as effective as beta-lactam-tobramycin combinations. The H. aphrophilus strain was not killed as effectively as other strains by any of the antibiotics.

Originalsprog	Engelsk
Tidsskrift	A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica
Vol/bind	100
Udgave nummer	9
Sider (fra-til)	856-60
Antal sider	5
ISSN	0903-4641
Status	Udgivet - 1992

Citationsformater

Killing curve activity of ciprofloxacin is comparable to synergistic effect of beta-lactam-tobramycin combinations against Haemophilus species endocarditis strains. / Westh, H; Frimodt-Møller, N; Gutschik, E et al.

I: A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica, Bind 100, Nr. 9, 1992, s. 856-60.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

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title = "Killing curve activity of ciprofloxacin is comparable to synergistic effect of beta-lactam-tobramycin combinations against Haemophilus species endocarditis strains",

abstract = "Nine Haemophilus species strains, all beta-lactamase negative, isolated from patients with endocarditis were tested in killing curve experiments. Antibiotics used were penicillin, amoxicillin, aztreonam alone and in combination with tobramycin, as well as ciprofloxacin alone. Synergism between beta-lactams and tobramycin with reduction of colony counts to zero was seen after 24 h for H. influenzae, H. parainfluenzae and H. segnis strains. Ciprofloxacin was as effective as beta-lactam-tobramycin combinations. The H. aphrophilus strain was not killed as effectively as other strains by any of the antibiotics.",

keywords = "Anti-Bacterial Agents, Ciprofloxacin, Drug Synergism, Endocarditis, Bacterial, Haemophilus, Humans, Microbial Sensitivity Tests, Tobramycin, beta-Lactams",

author = "H Westh and N Frimodt-M{\o}ller and E Gutschik and Bangsborg, {Jette Marie}",

year = "1992",

language = "English",

volume = "100",

pages = "856--60",

journal = "APMIS. Supplementum",

issn = "0903-465X",

publisher = "Wiley Online",

number = "9",

}

TY - JOUR

T1 - Killing curve activity of ciprofloxacin is comparable to synergistic effect of beta-lactam-tobramycin combinations against Haemophilus species endocarditis strains

AU - Westh, H

AU - Frimodt-Møller, N

AU - Gutschik, E

AU - Bangsborg, Jette Marie

PY - 1992

Y1 - 1992

N2 - Nine Haemophilus species strains, all beta-lactamase negative, isolated from patients with endocarditis were tested in killing curve experiments. Antibiotics used were penicillin, amoxicillin, aztreonam alone and in combination with tobramycin, as well as ciprofloxacin alone. Synergism between beta-lactams and tobramycin with reduction of colony counts to zero was seen after 24 h for H. influenzae, H. parainfluenzae and H. segnis strains. Ciprofloxacin was as effective as beta-lactam-tobramycin combinations. The H. aphrophilus strain was not killed as effectively as other strains by any of the antibiotics.

AB - Nine Haemophilus species strains, all beta-lactamase negative, isolated from patients with endocarditis were tested in killing curve experiments. Antibiotics used were penicillin, amoxicillin, aztreonam alone and in combination with tobramycin, as well as ciprofloxacin alone. Synergism between beta-lactams and tobramycin with reduction of colony counts to zero was seen after 24 h for H. influenzae, H. parainfluenzae and H. segnis strains. Ciprofloxacin was as effective as beta-lactam-tobramycin combinations. The H. aphrophilus strain was not killed as effectively as other strains by any of the antibiotics.

KW - Anti-Bacterial Agents

KW - Ciprofloxacin

KW - Drug Synergism

KW - Endocarditis, Bacterial

KW - Haemophilus

KW - Humans

KW - Microbial Sensitivity Tests

KW - Tobramycin

KW - beta-Lactams

M3 - Journal article

C2 - 1389104

SN - 0903-465X

VL - 100

SP - 856

EP - 860

JO - APMIS. Supplementum

JF - APMIS. Supplementum

IS - 9

ER -

Killing curve activity of ciprofloxacin is comparable to synergistic effect of beta-lactam-tobramycin combinations against Haemophilus species endocarditis strains

Abstract

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