Job strain and the risk of stroke: an individual-participant data meta-analysis

Eleonor I Fransson; Solja T Nyberg; Katriina Heikkilä; Lars Alfredsson; Jakob Bjørner; Marianne Borritz; Hermann Burr; Nico Dragano; Goedele A Geuskens; Marcel Goldberg; Mark Hamer; Wendela E Hooftman; Irene L Houtman; Matti Joensuu; Markus Jokela; Anders Knutsson; Markku Koskenvuo; Aki Koskinen; Meena Kumari; Constanze Leineweber; Thorsten Lunau; Ida E H Madsen; Linda L Magnusson Hanson; Martin L Nielsen; Maria Nordin; Tuula Oksanen; Jaana Pentti; Jan H Pejtersen; Reiner Rugulies; Paula Salo; Martin J Shipley; Andrew Steptoe; Sakari B Suominen; Töres Theorell; Salla Toppinen-Tanner; Jussi Vahtera; Marianna Virtanen; Ari Väänänen; Peter J M Westerholm; Hugo Westerlund; Marie Zins; Annie Britton; Eric J Brunner; Archana Singh-Manoux; G David Batty; Mika Kivimäki

doi:10.1161/STROKEAHA.114.008019

Job strain and the risk of stroke: an individual-participant data meta-analysis

Eleonor I Fransson, Solja T Nyberg, Katriina Heikkilä, Lars Alfredsson, Jakob Bjørner, Marianne Borritz, Hermann Burr, Nico Dragano, Goedele A Geuskens, Marcel Goldberg, Mark Hamer, Wendela E Hooftman, Irene L Houtman, Matti Joensuu, Markus Jokela, Anders Knutsson, Markku Koskenvuo, Aki Koskinen, Meena Kumari, Constanze LeineweberThorsten Lunau, Ida E H Madsen, Linda L Magnusson Hanson, Martin L Nielsen, Maria Nordin, Tuula Oksanen, Jaana Pentti, Jan H Pejtersen, Reiner Rugulies, Paula Salo, Martin J Shipley, Andrew Steptoe, Sakari B Suominen, Töres Theorell, Salla Toppinen-Tanner, Jussi Vahtera, Marianna Virtanen, Ari Väänänen, Peter J M Westerholm, Hugo Westerlund, Marie Zins, Annie Britton, Eric J Brunner, Archana Singh-Manoux, G David Batty, Mika Kivimäki

70 Citations (Scopus)

Abstract

BACKGROUND AND PURPOSE: Psychosocial stress at work has been proposed to be a risk factor for cardiovascular disease. However, its role as a risk factor for stroke is uncertain.

METHODS: We conducted an individual-participant-data meta-analysis of 196 380 males and females from 14 European cohort studies to investigate the association between job strain, a measure of work-related stress, and incident stroke.

RESULTS: In 1.8 million person-years at risk (mean follow-up 9.2 years), 2023 first-time stroke events were recorded. The age- and sex-adjusted hazard ratio for job strain relative to no job strain was 1.24 (95% confidence interval, 1.05;1.47) for ischemic stroke, 1.01 (95% confidence interval, 0.75;1.36) for hemorrhagic stroke, and 1.09 (95% confidence interval, 0.94;1.26) for overall stroke. The association with ischemic stroke was robust to further adjustment for socioeconomic status.

CONCLUSION: Job strain may be associated with an increased risk of ischemic stroke, but further research is needed to determine whether interventions targeting job strain would reduce stroke risk beyond existing preventive strategies.

Original language	English
Journal	Stroke
Volume	46
Issue number	2
Pages (from-to)	557-559
Number of pages	3
ISSN	0039-2499
DOIs	https://doi.org/10.1161/STROKEAHA.114.008019
Publication status	Published - 6 Feb 2015

Keywords

Cohort Studies
Female
Humans
Individuality
Job Satisfaction
Male
Prospective Studies
Risk Factors
Stress, Psychological
Stroke
Workload

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1161/STROKEAHA.114.008019

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Fransson, E. I., Nyberg, S. T., Heikkilä, K., Alfredsson, L., Bjørner, J., Borritz, M., Burr, H., Dragano, N., Geuskens, G. A., Goldberg, M., Hamer, M., Hooftman, W. E., Houtman, I. L., Joensuu, M., Jokela, M., Knutsson, A., Koskenvuo, M., Koskinen, A., Kumari, M., ... Kivimäki, M. (2015). Job strain and the risk of stroke: an individual-participant data meta-analysis. Stroke, 46(2), 557-559. https://doi.org/10.1161/STROKEAHA.114.008019

Fransson, EI, Nyberg, ST, Heikkilä, K, Alfredsson, L, Bjørner, J, Borritz, M, Burr, H, Dragano, N, Geuskens, GA, Goldberg, M, Hamer, M, Hooftman, WE, Houtman, IL, Joensuu, M, Jokela, M, Knutsson, A, Koskenvuo, M, Koskinen, A, Kumari, M, Leineweber, C, Lunau, T, Madsen, IEH, Hanson, LLM, Nielsen, ML, Nordin, M, Oksanen, T, Pentti, J, Pejtersen, JH, Rugulies, R, Salo, P, Shipley, MJ, Steptoe, A, Suominen, SB, Theorell, T, Toppinen-Tanner, S, Vahtera, J, Virtanen, M, Väänänen, A, Westerholm, PJM, Westerlund, H, Zins, M, Britton, A, Brunner, EJ, Singh-Manoux, A, Batty, GD & Kivimäki, M 2015, 'Job strain and the risk of stroke: an individual-participant data meta-analysis', Stroke, vol. 46, no. 2, pp. 557-559. https://doi.org/10.1161/STROKEAHA.114.008019

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abstract = "BACKGROUND AND PURPOSE: Psychosocial stress at work has been proposed to be a risk factor for cardiovascular disease. However, its role as a risk factor for stroke is uncertain.METHODS: We conducted an individual-participant-data meta-analysis of 196 380 males and females from 14 European cohort studies to investigate the association between job strain, a measure of work-related stress, and incident stroke.RESULTS: In 1.8 million person-years at risk (mean follow-up 9.2 years), 2023 first-time stroke events were recorded. The age- and sex-adjusted hazard ratio for job strain relative to no job strain was 1.24 (95% confidence interval, 1.05;1.47) for ischemic stroke, 1.01 (95% confidence interval, 0.75;1.36) for hemorrhagic stroke, and 1.09 (95% confidence interval, 0.94;1.26) for overall stroke. The association with ischemic stroke was robust to further adjustment for socioeconomic status.CONCLUSION: Job strain may be associated with an increased risk of ischemic stroke, but further research is needed to determine whether interventions targeting job strain would reduce stroke risk beyond existing preventive strategies.",

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TY - JOUR

T1 - Job strain and the risk of stroke

T2 - an individual-participant data meta-analysis

AU - Fransson, Eleonor I

AU - Nyberg, Solja T

AU - Heikkilä, Katriina

AU - Alfredsson, Lars

AU - Bjørner, Jakob

AU - Borritz, Marianne

AU - Burr, Hermann

AU - Dragano, Nico

AU - Geuskens, Goedele A

AU - Goldberg, Marcel

AU - Hamer, Mark

AU - Hooftman, Wendela E

AU - Houtman, Irene L

AU - Joensuu, Matti

AU - Jokela, Markus

AU - Knutsson, Anders

AU - Koskenvuo, Markku

AU - Koskinen, Aki

AU - Kumari, Meena

AU - Leineweber, Constanze

AU - Lunau, Thorsten

AU - Madsen, Ida E H

AU - Hanson, Linda L Magnusson

AU - Nielsen, Martin L

AU - Nordin, Maria

AU - Oksanen, Tuula

AU - Pentti, Jaana

AU - Pejtersen, Jan H

AU - Rugulies, Reiner

AU - Salo, Paula

AU - Shipley, Martin J

AU - Steptoe, Andrew

AU - Suominen, Sakari B

AU - Theorell, Töres

AU - Toppinen-Tanner, Salla

AU - Vahtera, Jussi

AU - Virtanen, Marianna

AU - Väänänen, Ari

AU - Westerholm, Peter J M

AU - Westerlund, Hugo

AU - Zins, Marie

AU - Britton, Annie

AU - Brunner, Eric J

AU - Singh-Manoux, Archana

AU - Batty, G David

AU - Kivimäki, Mika

PY - 2015/2/6

Y1 - 2015/2/6

N2 - BACKGROUND AND PURPOSE: Psychosocial stress at work has been proposed to be a risk factor for cardiovascular disease. However, its role as a risk factor for stroke is uncertain.METHODS: We conducted an individual-participant-data meta-analysis of 196 380 males and females from 14 European cohort studies to investigate the association between job strain, a measure of work-related stress, and incident stroke.RESULTS: In 1.8 million person-years at risk (mean follow-up 9.2 years), 2023 first-time stroke events were recorded. The age- and sex-adjusted hazard ratio for job strain relative to no job strain was 1.24 (95% confidence interval, 1.05;1.47) for ischemic stroke, 1.01 (95% confidence interval, 0.75;1.36) for hemorrhagic stroke, and 1.09 (95% confidence interval, 0.94;1.26) for overall stroke. The association with ischemic stroke was robust to further adjustment for socioeconomic status.CONCLUSION: Job strain may be associated with an increased risk of ischemic stroke, but further research is needed to determine whether interventions targeting job strain would reduce stroke risk beyond existing preventive strategies.

AB - BACKGROUND AND PURPOSE: Psychosocial stress at work has been proposed to be a risk factor for cardiovascular disease. However, its role as a risk factor for stroke is uncertain.METHODS: We conducted an individual-participant-data meta-analysis of 196 380 males and females from 14 European cohort studies to investigate the association between job strain, a measure of work-related stress, and incident stroke.RESULTS: In 1.8 million person-years at risk (mean follow-up 9.2 years), 2023 first-time stroke events were recorded. The age- and sex-adjusted hazard ratio for job strain relative to no job strain was 1.24 (95% confidence interval, 1.05;1.47) for ischemic stroke, 1.01 (95% confidence interval, 0.75;1.36) for hemorrhagic stroke, and 1.09 (95% confidence interval, 0.94;1.26) for overall stroke. The association with ischemic stroke was robust to further adjustment for socioeconomic status.CONCLUSION: Job strain may be associated with an increased risk of ischemic stroke, but further research is needed to determine whether interventions targeting job strain would reduce stroke risk beyond existing preventive strategies.

KW - Cohort Studies

KW - Female

KW - Humans

KW - Individuality

KW - Job Satisfaction

KW - Male

KW - Prospective Studies

KW - Risk Factors

KW - Stress, Psychological

KW - Stroke

KW - Workload

U2 - 10.1161/STROKEAHA.114.008019

DO - 10.1161/STROKEAHA.114.008019

M3 - Letter

C2 - 25563644

SN - 0039-2499

VL - 46

SP - 557

EP - 559

JO - Stroke

JF - Stroke

IS - 2

ER -

Job strain and the risk of stroke: an individual-participant data meta-analysis

Abstract

Keywords

UN SDGs

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