Job strain and the risk of stroke: an individual-participant data meta-analysis

Eleonor I Fransson; Solja T Nyberg; Katriina Heikkilä; Lars Alfredsson; Jakob Bjørner; Marianne Borritz; Hermann Burr; Nico Dragano; Goedele A Geuskens; Marcel Goldberg; Mark Hamer; Wendela E Hooftman; Irene L Houtman; Matti Joensuu; Markus Jokela; Anders Knutsson; Markku Koskenvuo; Aki Koskinen; Meena Kumari; Constanze Leineweber; Thorsten Lunau; Ida E H Madsen; Linda L Magnusson Hanson; Martin L Nielsen; Maria Nordin; Tuula Oksanen; Jaana Pentti; Jan H Pejtersen; Reiner Rugulies; Paula Salo; Martin J Shipley; Andrew Steptoe; Sakari B Suominen; Töres Theorell; Salla Toppinen-Tanner; Jussi Vahtera; Marianna Virtanen; Ari Väänänen; Peter J M Westerholm; Hugo Westerlund; Marie Zins; Annie Britton; Eric J Brunner; Archana Singh-Manoux; G David Batty; Mika Kivimäki

doi:10.1161/STROKEAHA.114.008019

Job strain and the risk of stroke: an individual-participant data meta-analysis

Eleonor I Fransson, Solja T Nyberg, Katriina Heikkilä, Lars Alfredsson, Jakob Bjørner, Marianne Borritz, Hermann Burr, Nico Dragano, Goedele A Geuskens, Marcel Goldberg, Mark Hamer, Wendela E Hooftman, Irene L Houtman, Matti Joensuu, Markus Jokela, Anders Knutsson, Markku Koskenvuo, Aki Koskinen, Meena Kumari, Constanze LeineweberThorsten Lunau, Ida E H Madsen, Linda L Magnusson Hanson, Martin L Nielsen, Maria Nordin, Tuula Oksanen, Jaana Pentti, Jan H Pejtersen, Reiner Rugulies, Paula Salo, Martin J Shipley, Andrew Steptoe, Sakari B Suominen, Töres Theorell, Salla Toppinen-Tanner, Jussi Vahtera, Marianna Virtanen, Ari Väänänen, Peter J M Westerholm, Hugo Westerlund, Marie Zins, Annie Britton, Eric J Brunner, Archana Singh-Manoux, G David Batty, Mika Kivimäki

70 Citationer (Scopus)

Abstract

BACKGROUND AND PURPOSE: Psychosocial stress at work has been proposed to be a risk factor for cardiovascular disease. However, its role as a risk factor for stroke is uncertain.

METHODS: We conducted an individual-participant-data meta-analysis of 196 380 males and females from 14 European cohort studies to investigate the association between job strain, a measure of work-related stress, and incident stroke.

RESULTS: In 1.8 million person-years at risk (mean follow-up 9.2 years), 2023 first-time stroke events were recorded. The age- and sex-adjusted hazard ratio for job strain relative to no job strain was 1.24 (95% confidence interval, 1.05;1.47) for ischemic stroke, 1.01 (95% confidence interval, 0.75;1.36) for hemorrhagic stroke, and 1.09 (95% confidence interval, 0.94;1.26) for overall stroke. The association with ischemic stroke was robust to further adjustment for socioeconomic status.

CONCLUSION: Job strain may be associated with an increased risk of ischemic stroke, but further research is needed to determine whether interventions targeting job strain would reduce stroke risk beyond existing preventive strategies.

Originalsprog	Engelsk
Tidsskrift	Stroke
Vol/bind	46
Udgave nummer	2
Sider (fra-til)	557-559
Antal sider	3
ISSN	0039-2499
DOI	https://doi.org/10.1161/STROKEAHA.114.008019
Status	Udgivet - 6 feb. 2015

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10.1161/STROKEAHA.114.008019

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Fransson, E. I., Nyberg, S. T., Heikkilä, K., Alfredsson, L., Bjørner, J., Borritz, M., Burr, H., Dragano, N., Geuskens, G. A., Goldberg, M., Hamer, M., Hooftman, W. E., Houtman, I. L., Joensuu, M., Jokela, M., Knutsson, A., Koskenvuo, M., Koskinen, A., Kumari, M., ... Kivimäki, M. (2015). Job strain and the risk of stroke: an individual-participant data meta-analysis. Stroke, 46(2), 557-559. https://doi.org/10.1161/STROKEAHA.114.008019

Fransson, EI, Nyberg, ST, Heikkilä, K, Alfredsson, L, Bjørner, J, Borritz, M, Burr, H, Dragano, N, Geuskens, GA, Goldberg, M, Hamer, M, Hooftman, WE, Houtman, IL, Joensuu, M, Jokela, M, Knutsson, A, Koskenvuo, M, Koskinen, A, Kumari, M, Leineweber, C, Lunau, T, Madsen, IEH, Hanson, LLM, Nielsen, ML, Nordin, M, Oksanen, T, Pentti, J, Pejtersen, JH, Rugulies, R, Salo, P, Shipley, MJ, Steptoe, A, Suominen, SB, Theorell, T, Toppinen-Tanner, S, Vahtera, J, Virtanen, M, Väänänen, A, Westerholm, PJM, Westerlund, H, Zins, M, Britton, A, Brunner, EJ, Singh-Manoux, A, Batty, GD & Kivimäki, M 2015, 'Job strain and the risk of stroke: an individual-participant data meta-analysis', Stroke, bind 46, nr. 2, s. 557-559. https://doi.org/10.1161/STROKEAHA.114.008019

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title = "Job strain and the risk of stroke: an individual-participant data meta-analysis",

abstract = "BACKGROUND AND PURPOSE: Psychosocial stress at work has been proposed to be a risk factor for cardiovascular disease. However, its role as a risk factor for stroke is uncertain.METHODS: We conducted an individual-participant-data meta-analysis of 196 380 males and females from 14 European cohort studies to investigate the association between job strain, a measure of work-related stress, and incident stroke.RESULTS: In 1.8 million person-years at risk (mean follow-up 9.2 years), 2023 first-time stroke events were recorded. The age- and sex-adjusted hazard ratio for job strain relative to no job strain was 1.24 (95% confidence interval, 1.05;1.47) for ischemic stroke, 1.01 (95% confidence interval, 0.75;1.36) for hemorrhagic stroke, and 1.09 (95% confidence interval, 0.94;1.26) for overall stroke. The association with ischemic stroke was robust to further adjustment for socioeconomic status.CONCLUSION: Job strain may be associated with an increased risk of ischemic stroke, but further research is needed to determine whether interventions targeting job strain would reduce stroke risk beyond existing preventive strategies.",

keywords = "Cohort Studies, Female, Humans, Individuality, Job Satisfaction, Male, Prospective Studies, Risk Factors, Stress, Psychological, Stroke, Workload",

author = "Fransson, {Eleonor I} and Nyberg, {Solja T} and Katriina Heikkil{\"a} and Lars Alfredsson and Jakob Bj{\o}rner and Marianne Borritz and Hermann Burr and Nico Dragano and Geuskens, {Goedele A} and Marcel Goldberg and Mark Hamer and Hooftman, {Wendela E} and Houtman, {Irene L} and Matti Joensuu and Markus Jokela and Anders Knutsson and Markku Koskenvuo and Aki Koskinen and Meena Kumari and Constanze Leineweber and Thorsten Lunau and Madsen, {Ida E H} and Hanson, {Linda L Magnusson} and Nielsen, {Martin L} and Maria Nordin and Tuula Oksanen and Jaana Pentti and Pejtersen, {Jan H} and Reiner Rugulies and Paula Salo and Shipley, {Martin J} and Andrew Steptoe and Suominen, {Sakari B} and T{\"o}res Theorell and Salla Toppinen-Tanner and Jussi Vahtera and Marianna Virtanen and Ari V{\"a}{\"a}n{\"a}nen and Westerholm, {Peter J M} and Hugo Westerlund and Marie Zins and Annie Britton and Brunner, {Eric J} and Archana Singh-Manoux and Batty, {G David} and Mika Kivim{\"a}ki",

note = "{\textcopyright} 2015 American Heart Association, Inc.",

year = "2015",

month = feb,

day = "6",

doi = "10.1161/STROKEAHA.114.008019",

language = "English",

volume = "46",

pages = "557--559",

journal = "Stroke",

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publisher = "Lippincott Williams & Wilkins",

number = "2",

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TY - JOUR

T1 - Job strain and the risk of stroke

T2 - an individual-participant data meta-analysis

AU - Fransson, Eleonor I

AU - Nyberg, Solja T

AU - Heikkilä, Katriina

AU - Alfredsson, Lars

AU - Bjørner, Jakob

AU - Borritz, Marianne

AU - Burr, Hermann

AU - Dragano, Nico

AU - Geuskens, Goedele A

AU - Goldberg, Marcel

AU - Hamer, Mark

AU - Hooftman, Wendela E

AU - Houtman, Irene L

AU - Joensuu, Matti

AU - Jokela, Markus

AU - Knutsson, Anders

AU - Koskenvuo, Markku

AU - Koskinen, Aki

AU - Kumari, Meena

AU - Leineweber, Constanze

AU - Lunau, Thorsten

AU - Madsen, Ida E H

AU - Hanson, Linda L Magnusson

AU - Nielsen, Martin L

AU - Nordin, Maria

AU - Oksanen, Tuula

AU - Pentti, Jaana

AU - Pejtersen, Jan H

AU - Rugulies, Reiner

AU - Salo, Paula

AU - Shipley, Martin J

AU - Steptoe, Andrew

AU - Suominen, Sakari B

AU - Theorell, Töres

AU - Toppinen-Tanner, Salla

AU - Vahtera, Jussi

AU - Virtanen, Marianna

AU - Väänänen, Ari

AU - Westerholm, Peter J M

AU - Westerlund, Hugo

AU - Zins, Marie

AU - Britton, Annie

AU - Brunner, Eric J

AU - Singh-Manoux, Archana

AU - Batty, G David

AU - Kivimäki, Mika

PY - 2015/2/6

Y1 - 2015/2/6

N2 - BACKGROUND AND PURPOSE: Psychosocial stress at work has been proposed to be a risk factor for cardiovascular disease. However, its role as a risk factor for stroke is uncertain.METHODS: We conducted an individual-participant-data meta-analysis of 196 380 males and females from 14 European cohort studies to investigate the association between job strain, a measure of work-related stress, and incident stroke.RESULTS: In 1.8 million person-years at risk (mean follow-up 9.2 years), 2023 first-time stroke events were recorded. The age- and sex-adjusted hazard ratio for job strain relative to no job strain was 1.24 (95% confidence interval, 1.05;1.47) for ischemic stroke, 1.01 (95% confidence interval, 0.75;1.36) for hemorrhagic stroke, and 1.09 (95% confidence interval, 0.94;1.26) for overall stroke. The association with ischemic stroke was robust to further adjustment for socioeconomic status.CONCLUSION: Job strain may be associated with an increased risk of ischemic stroke, but further research is needed to determine whether interventions targeting job strain would reduce stroke risk beyond existing preventive strategies.

AB - BACKGROUND AND PURPOSE: Psychosocial stress at work has been proposed to be a risk factor for cardiovascular disease. However, its role as a risk factor for stroke is uncertain.METHODS: We conducted an individual-participant-data meta-analysis of 196 380 males and females from 14 European cohort studies to investigate the association between job strain, a measure of work-related stress, and incident stroke.RESULTS: In 1.8 million person-years at risk (mean follow-up 9.2 years), 2023 first-time stroke events were recorded. The age- and sex-adjusted hazard ratio for job strain relative to no job strain was 1.24 (95% confidence interval, 1.05;1.47) for ischemic stroke, 1.01 (95% confidence interval, 0.75;1.36) for hemorrhagic stroke, and 1.09 (95% confidence interval, 0.94;1.26) for overall stroke. The association with ischemic stroke was robust to further adjustment for socioeconomic status.CONCLUSION: Job strain may be associated with an increased risk of ischemic stroke, but further research is needed to determine whether interventions targeting job strain would reduce stroke risk beyond existing preventive strategies.

KW - Cohort Studies

KW - Female

KW - Humans

KW - Individuality

KW - Job Satisfaction

KW - Male

KW - Prospective Studies

KW - Risk Factors

KW - Stress, Psychological

KW - Stroke

KW - Workload

U2 - 10.1161/STROKEAHA.114.008019

DO - 10.1161/STROKEAHA.114.008019

M3 - Letter

C2 - 25563644

SN - 0039-2499

VL - 46

SP - 557

EP - 559

JO - Stroke

JF - Stroke

IS - 2

ER -

Job strain and the risk of stroke: an individual-participant data meta-analysis

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