IUGR does not predispose to necrotizing enterocolitis or compromise postnatal intestinal adaptation in preterm pigs

Lianqiang Che; Thomas Thymann; Stine Brandt Bering; Isabelle Le Huërou-Luron; Romain D'Inca; Keying Zhang; Per Torp Sangild

IUGR does not predispose to necrotizing enterocolitis or compromise postnatal intestinal adaptation in preterm pigs

Lianqiang Che, Thomas Thymann, Stine Brandt Bering, Isabelle Le Huërou-Luron, Romain D'Inca, Keying Zhang, Per Torp Sangild

38 Citations (Scopus)

Abstract

IUGR and preterm birth are leading causes of neonatal morbidity. We tested the hypothesis that IUGR predisposes to gut maladaption and necrotizing enterocolitis (NEC) using preterm pigs as models for preterm infants. First, full-term normal birth weight (NW) and IUGR (∼65% of NW) pigs were compared. IUGR reduced intestinal weight per length, proportion mucosa, villous area, and sucrase activity at 2 d after birth (p < 0.05) but did not change relative organ weights. Next, groups of preterm pigs were fed formula or colostrum, starting at birth or after 2-3 d of total parenteral nutrition (TPN). Neonatal mortality (not related to NEC) was increased in IUGR versus NW preterm pigs (28 vs 10%, p < 0.01). NEC incidence was similar between IUGR and NW but higher after formula than colostrum feeding (46 vs 12%, p < 0.01) and higher after TPN than without TPN (61 vs 34% for formula pigs, p < 0.01). After feeding, relative intestinal mass and length were higher in IUGR versus NW pigs (+25-80%, p < 0.05) while brush border enzyme activities were similar. An enhanced gut trophic response to enteral feeding may help to improve postnatal intestinal adaptation and NEC resistance in preterm IUGR newborns.

Original language	English
Journal	Pediatric Research
Volume	67
Issue number	1
Pages (from-to)	54-59
Number of pages	6
ISSN	0031-3998
Publication status	Published - Jan 2010

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Che, L., Thymann, T., Bering, S. B., Huërou-Luron, I. L., D'Inca, R., Zhang, K., & Sangild, P. T. (2010). IUGR does not predispose to necrotizing enterocolitis or compromise postnatal intestinal adaptation in preterm pigs. Pediatric Research, 67(1), 54-59. http://ovidsp.uk.ovid.com.ep.fjernadgang.kb.dk/sp-3.2.4b/ovidweb.cgi?&S=APMCPDFNGOHFOBPOFNDLBCJHLCAEAA00&Link+Set=S.sh.15.17.22.27|10|sl_10

Che, L, Thymann, T , Bering, SB, Huërou-Luron, IL, D'Inca, R, Zhang, K & Sangild, PT 2010, 'IUGR does not predispose to necrotizing enterocolitis or compromise postnatal intestinal adaptation in preterm pigs', Pediatric Research, vol. 67, no. 1, pp. 54-59. <http://ovidsp.uk.ovid.com.ep.fjernadgang.kb.dk/sp-3.2.4b/ovidweb.cgi?&S=APMCPDFNGOHFOBPOFNDLBCJHLCAEAA00&Link+Set=S.sh.15.17.22.27|10|sl_10>

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title = "IUGR does not predispose to necrotizing enterocolitis or compromise postnatal intestinal adaptation in preterm pigs",

abstract = "IUGR and preterm birth are leading causes of neonatal morbidity. We tested the hypothesis that IUGR predisposes to gut maladaption and necrotizing enterocolitis (NEC) using preterm pigs as models for preterm infants. First, full-term normal birth weight (NW) and IUGR (∼65% of NW) pigs were compared. IUGR reduced intestinal weight per length, proportion mucosa, villous area, and sucrase activity at 2 d after birth (p < 0.05) but did not change relative organ weights. Next, groups of preterm pigs were fed formula or colostrum, starting at birth or after 2-3 d of total parenteral nutrition (TPN). Neonatal mortality (not related to NEC) was increased in IUGR versus NW preterm pigs (28 vs 10%, p < 0.01). NEC incidence was similar between IUGR and NW but higher after formula than colostrum feeding (46 vs 12%, p < 0.01) and higher after TPN than without TPN (61 vs 34% for formula pigs, p < 0.01). After feeding, relative intestinal mass and length were higher in IUGR versus NW pigs (+25-80%, p < 0.05) while brush border enzyme activities were similar. An enhanced gut trophic response to enteral feeding may help to improve postnatal intestinal adaptation and NEC resistance in preterm IUGR newborns.",

author = "Lianqiang Che and Thomas Thymann and Bering, {Stine Brandt} and Hu{\"e}rou-Luron, {Isabelle Le} and Romain D'Inca and Keying Zhang and Sangild, {Per Torp}",

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T1 - IUGR does not predispose to necrotizing enterocolitis or compromise postnatal intestinal adaptation in preterm pigs

AU - Che, Lianqiang

AU - Thymann, Thomas

AU - Bering, Stine Brandt

AU - Huërou-Luron, Isabelle Le

AU - D'Inca, Romain

AU - Zhang, Keying

AU - Sangild, Per Torp

PY - 2010/1

Y1 - 2010/1

N2 - IUGR and preterm birth are leading causes of neonatal morbidity. We tested the hypothesis that IUGR predisposes to gut maladaption and necrotizing enterocolitis (NEC) using preterm pigs as models for preterm infants. First, full-term normal birth weight (NW) and IUGR (∼65% of NW) pigs were compared. IUGR reduced intestinal weight per length, proportion mucosa, villous area, and sucrase activity at 2 d after birth (p < 0.05) but did not change relative organ weights. Next, groups of preterm pigs were fed formula or colostrum, starting at birth or after 2-3 d of total parenteral nutrition (TPN). Neonatal mortality (not related to NEC) was increased in IUGR versus NW preterm pigs (28 vs 10%, p < 0.01). NEC incidence was similar between IUGR and NW but higher after formula than colostrum feeding (46 vs 12%, p < 0.01) and higher after TPN than without TPN (61 vs 34% for formula pigs, p < 0.01). After feeding, relative intestinal mass and length were higher in IUGR versus NW pigs (+25-80%, p < 0.05) while brush border enzyme activities were similar. An enhanced gut trophic response to enteral feeding may help to improve postnatal intestinal adaptation and NEC resistance in preterm IUGR newborns.

AB - IUGR and preterm birth are leading causes of neonatal morbidity. We tested the hypothesis that IUGR predisposes to gut maladaption and necrotizing enterocolitis (NEC) using preterm pigs as models for preterm infants. First, full-term normal birth weight (NW) and IUGR (∼65% of NW) pigs were compared. IUGR reduced intestinal weight per length, proportion mucosa, villous area, and sucrase activity at 2 d after birth (p < 0.05) but did not change relative organ weights. Next, groups of preterm pigs were fed formula or colostrum, starting at birth or after 2-3 d of total parenteral nutrition (TPN). Neonatal mortality (not related to NEC) was increased in IUGR versus NW preterm pigs (28 vs 10%, p < 0.01). NEC incidence was similar between IUGR and NW but higher after formula than colostrum feeding (46 vs 12%, p < 0.01) and higher after TPN than without TPN (61 vs 34% for formula pigs, p < 0.01). After feeding, relative intestinal mass and length were higher in IUGR versus NW pigs (+25-80%, p < 0.05) while brush border enzyme activities were similar. An enhanced gut trophic response to enteral feeding may help to improve postnatal intestinal adaptation and NEC resistance in preterm IUGR newborns.

M3 - Journal article

SN - 0031-3998

VL - 67

SP - 54

EP - 59

JO - Pediatric Research

JF - Pediatric Research

IS - 1

ER -

IUGR does not predispose to necrotizing enterocolitis or compromise postnatal intestinal adaptation in preterm pigs

Abstract

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