ISFG: Recommendations on biostatistics in paternity testing

TY - JOUR

T1 - ISFG: Recommendations on biostatistics in paternity testing

AU - Gjertson, David W

AU - Brenner, Charles H

AU - Baur, Max P

AU - Carracedo, Angel

AU - Guidet, Francois

AU - Luque, Juan A

AU - Lessig, Rüdiger

AU - Mayr, Wolfgang R

AU - Pascali, Vince L

AU - Prinz, Mechthild

AU - Schneider, Peter M

AU - Morling, Niels

N1 - Keywords: Biometry; Chromosomes, Human, Y; DNA, Mitochondrial; Female; Forensic Genetics; Genetic Markers; Genetics, Population; Humans; Likelihood Functions; Male; Paternity; Pregnancy; Societies, Scientific

PY - 2007

Y1 - 2007

N2 - The Paternity Testing Commission (PTC) of the International Society for Forensic Genetics has taken up the task of establishing the biostatistical recommendations in accordance with the ISO 17025 standards and a previous set of ISFG recommendations specific to the genetic investigations in paternity cases. In the initial set, the PTC recommended that biostatistical evaluations of paternity are based on a likelihood ratio principle - yielding the paternity index, PI. Here, we have made five supplementary biostatistical recommendations. The first recommendation clarifies and defines basic concepts of genetic hypotheses and calculation concerns needed to produce valid PIs. The second and third recommendations address issues associated with population genetics (allele probabilities, Y-chromosome markers, mtDNA, and population substructuring) and special circumstances (deficiency/reconstruction and immigration cases), respectively. The fourth recommendation considers strategies regarding genetic evidence against paternity. The fifth recommendation covers necessary documentation, reporting details and assumptions underlying calculations. The PTC strongly suggests that these recommendations should be adopted by all laboratories involved in paternity testing as the basis for their biostatistical analysis.

AB - The Paternity Testing Commission (PTC) of the International Society for Forensic Genetics has taken up the task of establishing the biostatistical recommendations in accordance with the ISO 17025 standards and a previous set of ISFG recommendations specific to the genetic investigations in paternity cases. In the initial set, the PTC recommended that biostatistical evaluations of paternity are based on a likelihood ratio principle - yielding the paternity index, PI. Here, we have made five supplementary biostatistical recommendations. The first recommendation clarifies and defines basic concepts of genetic hypotheses and calculation concerns needed to produce valid PIs. The second and third recommendations address issues associated with population genetics (allele probabilities, Y-chromosome markers, mtDNA, and population substructuring) and special circumstances (deficiency/reconstruction and immigration cases), respectively. The fourth recommendation considers strategies regarding genetic evidence against paternity. The fifth recommendation covers necessary documentation, reporting details and assumptions underlying calculations. The PTC strongly suggests that these recommendations should be adopted by all laboratories involved in paternity testing as the basis for their biostatistical analysis.

U2 - 10.1016/j.fsigen.2007.06.006

DO - 10.1016/j.fsigen.2007.06.006

M3 - Journal article

C2 - 19083766

SN - 1872-4973

VL - 1

SP - 223

EP - 231

JO - Forensic Science International: Genetics

JF - Forensic Science International: Genetics

IS - 3-4

ER -