Is development of hyperalgesia, allodynia and myoclonus related to morphine metabolism during long-term administration?: Six case histories

P Sjøgren; L P Thunedborg; Lona Louring Christrup; S H Hansen; J Franks

Is development of hyperalgesia, allodynia and myoclonus related to morphine metabolism during long-term administration? Six case histories

P Sjøgren, L P Thunedborg, Lona Louring Christrup, S H Hansen, J Franks

83 Citations (Scopus)

Abstract

Recently, clinical reports have suggested a relationship between the occurrence of hyperalgesia, allodynia and/or myoclonus and treatment with high doses of morphine in humans. Although few clinical descriptions of these phenomena are available, experimental work supports the notion that high doses of morphine may play a pathogenetic role in the observed behavioural syndrome.

Original language	English
Journal	Acta Anaesthesiologica Scandinavica
Volume	42
Issue number	9
Pages (from-to)	1070-5
Number of pages	6
ISSN	0001-5172
Publication status	Published - Oct 1998

Keywords

Aged
Analgesics, Opioid
Female
Glucuronosyltransferase
Humans
Hyperalgesia
Male
Middle Aged
Morphine
Morphine Derivatives
Myoclonus

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http://onlinelibrary.wiley.com/doi/10.1111/j.1399-6576.1998.tb05378.x/abstract

Cite this

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title = "Is development of hyperalgesia, allodynia and myoclonus related to morphine metabolism during long-term administration?: Six case histories",

abstract = "Recently, clinical reports have suggested a relationship between the occurrence of hyperalgesia, allodynia and/or myoclonus and treatment with high doses of morphine in humans. Although few clinical descriptions of these phenomena are available, experimental work supports the notion that high doses of morphine may play a pathogenetic role in the observed behavioural syndrome.",

keywords = "Aged, Analgesics, Opioid, Female, Glucuronosyltransferase, Humans, Hyperalgesia, Male, Middle Aged, Morphine, Morphine Derivatives, Myoclonus",

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year = "1998",

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T1 - Is development of hyperalgesia, allodynia and myoclonus related to morphine metabolism during long-term administration?

T2 - Six case histories

AU - Sjøgren, P

AU - Thunedborg, L P

AU - Christrup, Lona Louring

AU - Hansen, S H

AU - Franks, J

PY - 1998/10

Y1 - 1998/10

N2 - Recently, clinical reports have suggested a relationship between the occurrence of hyperalgesia, allodynia and/or myoclonus and treatment with high doses of morphine in humans. Although few clinical descriptions of these phenomena are available, experimental work supports the notion that high doses of morphine may play a pathogenetic role in the observed behavioural syndrome.

AB - Recently, clinical reports have suggested a relationship between the occurrence of hyperalgesia, allodynia and/or myoclonus and treatment with high doses of morphine in humans. Although few clinical descriptions of these phenomena are available, experimental work supports the notion that high doses of morphine may play a pathogenetic role in the observed behavioural syndrome.

KW - Aged

KW - Analgesics, Opioid

KW - Female

KW - Glucuronosyltransferase

KW - Humans

KW - Hyperalgesia

KW - Male

KW - Middle Aged

KW - Morphine

KW - Morphine Derivatives

KW - Myoclonus

M3 - Journal article

C2 - 9809090

SN - 0001-5172

VL - 42

SP - 1070

EP - 1075

JO - Acta Anaesthesiologica Scandinavica

JF - Acta Anaesthesiologica Scandinavica

IS - 9

ER -

Is development of hyperalgesia, allodynia and myoclonus related to morphine metabolism during long-term administration? Six case histories

Abstract

Keywords

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