Ionic signalling in astroglia beyond calcium

Alexei Verkhratsky; Verena Untiet; Christine R. Rose

doi:10.1113/jp277478

Ionic signalling in astroglia beyond calcium

Alexei Verkhratsky^*, Verena Untiet, Christine R. Rose

^*Corresponding author for this work

22 Citations (Scopus)

Abstract

Astrocytes are homeostatic and protective cells of the central nervous system. Astroglial homeostatic responses are tightly coordinated with neuronal activity. Astrocytes maintain neuronal excitability through regulation of extracellular ion concentrations, as well as assisting and modulating synaptic transmission by uptake and catabolism of major neurotransmitters. Moreover, they support neuronal metabolism and detoxify ammonium and reactive oxygen species. Astroglial homeostatic actions are initiated and controlled by intercellular signalling of ions, including Ca ²⁺ , Na ⁺ , Cl ⁻ , H ⁺ and possibly K ⁺ . This review summarises current knowledge on ionic signals mediated by the major monovalent ions, which occur in microdomains, as global events, or as propagating intercellular waves and thereby represent the substrate for astroglial excitability. (Figure presented.).

Original language	English
Journal	The Journal of Physiology
Number of pages	16
ISSN	0022-3751
DOIs	https://doi.org/10.1113/jp277478
Publication status	Published - 1 May 2020

Keywords

Astrocytes
Cl signalling
H homeostasis
K homoeostasis
Na signalling

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title = "Ionic signalling in astroglia beyond calcium",

abstract = " Astrocytes are homeostatic and protective cells of the central nervous system. Astroglial homeostatic responses are tightly coordinated with neuronal activity. Astrocytes maintain neuronal excitability through regulation of extracellular ion concentrations, as well as assisting and modulating synaptic transmission by uptake and catabolism of major neurotransmitters. Moreover, they support neuronal metabolism and detoxify ammonium and reactive oxygen species. Astroglial homeostatic actions are initiated and controlled by intercellular signalling of ions, including Ca 2+ , Na + , Cl − , H + and possibly K + . This review summarises current knowledge on ionic signals mediated by the major monovalent ions, which occur in microdomains, as global events, or as propagating intercellular waves and thereby represent the substrate for astroglial excitability. (Figure presented.). ",

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T1 - Ionic signalling in astroglia beyond calcium

AU - Verkhratsky, Alexei

AU - Untiet, Verena

AU - Rose, Christine R.

PY - 2020/5/1

Y1 - 2020/5/1

N2 - Astrocytes are homeostatic and protective cells of the central nervous system. Astroglial homeostatic responses are tightly coordinated with neuronal activity. Astrocytes maintain neuronal excitability through regulation of extracellular ion concentrations, as well as assisting and modulating synaptic transmission by uptake and catabolism of major neurotransmitters. Moreover, they support neuronal metabolism and detoxify ammonium and reactive oxygen species. Astroglial homeostatic actions are initiated and controlled by intercellular signalling of ions, including Ca 2+ , Na + , Cl − , H + and possibly K + . This review summarises current knowledge on ionic signals mediated by the major monovalent ions, which occur in microdomains, as global events, or as propagating intercellular waves and thereby represent the substrate for astroglial excitability. (Figure presented.).

AB - Astrocytes are homeostatic and protective cells of the central nervous system. Astroglial homeostatic responses are tightly coordinated with neuronal activity. Astrocytes maintain neuronal excitability through regulation of extracellular ion concentrations, as well as assisting and modulating synaptic transmission by uptake and catabolism of major neurotransmitters. Moreover, they support neuronal metabolism and detoxify ammonium and reactive oxygen species. Astroglial homeostatic actions are initiated and controlled by intercellular signalling of ions, including Ca 2+ , Na + , Cl − , H + and possibly K + . This review summarises current knowledge on ionic signals mediated by the major monovalent ions, which occur in microdomains, as global events, or as propagating intercellular waves and thereby represent the substrate for astroglial excitability. (Figure presented.).

KW - Astrocytes

KW - Cl signalling

KW - H homeostasis

KW - K homoeostasis

KW - Na signalling

U2 - 10.1113/jp277478

DO - 10.1113/jp277478

M3 - Review

C2 - 30734296

AN - SCOPUS:85062593885

SN - 0022-3751

JO - The Journal of Physiology

JF - The Journal of Physiology

ER -

Ionic signalling in astroglia beyond calcium

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Keywords

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