Ionic signalling in astroglia beyond calcium

Alexei Verkhratsky; Verena Untiet; Christine R. Rose

doi:10.1113/jp277478

Ionic signalling in astroglia beyond calcium

Alexei Verkhratsky^*, Verena Untiet, Christine R. Rose

^*Corresponding author af dette arbejde

22 Citationer (Scopus)

Abstract

Astrocytes are homeostatic and protective cells of the central nervous system. Astroglial homeostatic responses are tightly coordinated with neuronal activity. Astrocytes maintain neuronal excitability through regulation of extracellular ion concentrations, as well as assisting and modulating synaptic transmission by uptake and catabolism of major neurotransmitters. Moreover, they support neuronal metabolism and detoxify ammonium and reactive oxygen species. Astroglial homeostatic actions are initiated and controlled by intercellular signalling of ions, including Ca ²⁺ , Na ⁺ , Cl ⁻ , H ⁺ and possibly K ⁺ . This review summarises current knowledge on ionic signals mediated by the major monovalent ions, which occur in microdomains, as global events, or as propagating intercellular waves and thereby represent the substrate for astroglial excitability. (Figure presented.).

Originalsprog	Engelsk
Tidsskrift	The Journal of Physiology
Antal sider	16
ISSN	0022-3751
DOI	https://doi.org/10.1113/jp277478
Status	Udgivet - 1 maj 2020

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title = "Ionic signalling in astroglia beyond calcium",

abstract = " Astrocytes are homeostatic and protective cells of the central nervous system. Astroglial homeostatic responses are tightly coordinated with neuronal activity. Astrocytes maintain neuronal excitability through regulation of extracellular ion concentrations, as well as assisting and modulating synaptic transmission by uptake and catabolism of major neurotransmitters. Moreover, they support neuronal metabolism and detoxify ammonium and reactive oxygen species. Astroglial homeostatic actions are initiated and controlled by intercellular signalling of ions, including Ca 2+ , Na + , Cl − , H + and possibly K + . This review summarises current knowledge on ionic signals mediated by the major monovalent ions, which occur in microdomains, as global events, or as propagating intercellular waves and thereby represent the substrate for astroglial excitability. (Figure presented.). ",

keywords = "Astrocytes, Cl signalling, H homeostasis, K homoeostasis, Na signalling",

author = "Alexei Verkhratsky and Verena Untiet and Rose, {Christine R.}",

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language = "English",

journal = "The Journal of Physiology",

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TY - JOUR

T1 - Ionic signalling in astroglia beyond calcium

AU - Verkhratsky, Alexei

AU - Untiet, Verena

AU - Rose, Christine R.

PY - 2020/5/1

Y1 - 2020/5/1

N2 - Astrocytes are homeostatic and protective cells of the central nervous system. Astroglial homeostatic responses are tightly coordinated with neuronal activity. Astrocytes maintain neuronal excitability through regulation of extracellular ion concentrations, as well as assisting and modulating synaptic transmission by uptake and catabolism of major neurotransmitters. Moreover, they support neuronal metabolism and detoxify ammonium and reactive oxygen species. Astroglial homeostatic actions are initiated and controlled by intercellular signalling of ions, including Ca 2+ , Na + , Cl − , H + and possibly K + . This review summarises current knowledge on ionic signals mediated by the major monovalent ions, which occur in microdomains, as global events, or as propagating intercellular waves and thereby represent the substrate for astroglial excitability. (Figure presented.).

AB - Astrocytes are homeostatic and protective cells of the central nervous system. Astroglial homeostatic responses are tightly coordinated with neuronal activity. Astrocytes maintain neuronal excitability through regulation of extracellular ion concentrations, as well as assisting and modulating synaptic transmission by uptake and catabolism of major neurotransmitters. Moreover, they support neuronal metabolism and detoxify ammonium and reactive oxygen species. Astroglial homeostatic actions are initiated and controlled by intercellular signalling of ions, including Ca 2+ , Na + , Cl − , H + and possibly K + . This review summarises current knowledge on ionic signals mediated by the major monovalent ions, which occur in microdomains, as global events, or as propagating intercellular waves and thereby represent the substrate for astroglial excitability. (Figure presented.).

KW - Astrocytes

KW - Cl signalling

KW - H homeostasis

KW - K homoeostasis

KW - Na signalling

U2 - 10.1113/jp277478

DO - 10.1113/jp277478

M3 - Review

C2 - 30734296

AN - SCOPUS:85062593885

SN - 0022-3751

JO - The Journal of Physiology

JF - The Journal of Physiology

ER -

Ionic signalling in astroglia beyond calcium

Abstract

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