Abstract
Cytosolic calcium ([Ca2+]i) has been suggested as a key modulator in the regulation of active sodium transport across electrically "tight" (high resistance) epithelia. In this study we investigated the effects of calcium on cellular electrophysiological parameters in a classical model tissue, the frog skin. [Ca2+]i was measured with fura-2 in an epifluorescence microscope setup. An inhibition of basolateral potassium permeability was observed when cytosolic calcium was increased. This inhibition was reversible upon removal of calcium from the serosal solution.
| Original language | English |
|---|---|
| Journal | Pflügers Archiv - European Journal of Physiology |
| Volume | 426 |
| Issue number | 1-2 |
| Pages (from-to) | 171-3 |
| Number of pages | 3 |
| ISSN | 0031-6768 |
| Publication status | Published - 1994 |
Keywords
- Animals
- Calcium
- Cytosol
- Epithelium
- Indomethacin
- Intracellular Fluid
- Ion Transport
- Membrane Potentials
- Permeability
- Potassium
- Rana temporaria
- Skin