Intracellular calcium modulates basolateral K(+)-permeability in frog skin epithelium

Birger Brodin; K A Rytved; R Nielsen

Intracellular calcium modulates basolateral K(+)-permeability in frog skin epithelium

Bioinformatik og RNA Biologi

11 Citationer (Scopus)

Abstract

Cytosolic calcium ([Ca2+]i) has been suggested as a key modulator in the regulation of active sodium transport across electrically "tight" (high resistance) epithelia. In this study we investigated the effects of calcium on cellular electrophysiological parameters in a classical model tissue, the frog skin. [Ca2+]i was measured with fura-2 in an epifluorescence microscope setup. An inhibition of basolateral potassium permeability was observed when cytosolic calcium was increased. This inhibition was reversible upon removal of calcium from the serosal solution.

Originalsprog	Engelsk
Tidsskrift	Pflügers Archiv - European Journal of Physiology
Vol/bind	426
Udgave nummer	1-2
Sider (fra-til)	171-3
Antal sider	3
ISSN	0031-6768
Status	Udgivet - 1994

Citationsformater

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title = "Intracellular calcium modulates basolateral K(+)-permeability in frog skin epithelium",

abstract = "Cytosolic calcium ([Ca2+]i) has been suggested as a key modulator in the regulation of active sodium transport across electrically {"}tight{"} (high resistance) epithelia. In this study we investigated the effects of calcium on cellular electrophysiological parameters in a classical model tissue, the frog skin. [Ca2+]i was measured with fura-2 in an epifluorescence microscope setup. An inhibition of basolateral potassium permeability was observed when cytosolic calcium was increased. This inhibition was reversible upon removal of calcium from the serosal solution.",

keywords = "Animals, Calcium, Cytosol, Epithelium, Indomethacin, Intracellular Fluid, Ion Transport, Membrane Potentials, Permeability, Potassium, Rana temporaria, Skin",

author = "Birger Brodin and Rytved, {K A} and R Nielsen",

year = "1994",

language = "English",

volume = "426",

pages = "171--3",

journal = "Pfl{\"u}gers Archiv - European Journal of Physiology",

issn = "0031-6768",

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number = "1-2",

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TY - JOUR

T1 - Intracellular calcium modulates basolateral K(+)-permeability in frog skin epithelium

AU - Brodin, Birger

AU - Rytved, K A

AU - Nielsen, R

PY - 1994

Y1 - 1994

N2 - Cytosolic calcium ([Ca2+]i) has been suggested as a key modulator in the regulation of active sodium transport across electrically "tight" (high resistance) epithelia. In this study we investigated the effects of calcium on cellular electrophysiological parameters in a classical model tissue, the frog skin. [Ca2+]i was measured with fura-2 in an epifluorescence microscope setup. An inhibition of basolateral potassium permeability was observed when cytosolic calcium was increased. This inhibition was reversible upon removal of calcium from the serosal solution.

AB - Cytosolic calcium ([Ca2+]i) has been suggested as a key modulator in the regulation of active sodium transport across electrically "tight" (high resistance) epithelia. In this study we investigated the effects of calcium on cellular electrophysiological parameters in a classical model tissue, the frog skin. [Ca2+]i was measured with fura-2 in an epifluorescence microscope setup. An inhibition of basolateral potassium permeability was observed when cytosolic calcium was increased. This inhibition was reversible upon removal of calcium from the serosal solution.

KW - Animals

KW - Calcium

KW - Cytosol

KW - Epithelium

KW - Indomethacin

KW - Intracellular Fluid

KW - Ion Transport

KW - Membrane Potentials

KW - Permeability

KW - Potassium

KW - Rana temporaria

KW - Skin

M3 - Journal article

C2 - 8146019

SN - 0031-6768

VL - 426

SP - 171

EP - 173

JO - Pflügers Archiv - European Journal of Physiology

JF - Pflügers Archiv - European Journal of Physiology

IS - 1-2

ER -

Intracellular calcium modulates basolateral K(+)-permeability in frog skin epithelium

Abstract

Fingeraftryk

Citationsformater