Interventions for age-related diseases: Shifting the paradigm

Inês Figueira; Adelaide Fernandes; Aleksandra Mladenovic Djordjevic; Andres Lopez-Contreras; Catarina M Henriques; Colin Selman; Elisabete Ferreiro; Efstathios S Gonos; José Luis Trejo; Juhi Misra; Lene Juel Rasmussen; Sara Xapelli; Timothy Ellam; Ilaria Bellantuono

doi:10.1016/j.mad.2016.09.009

Interventions for age-related diseases: Shifting the paradigm

Inês Figueira, Adelaide Fernandes, Aleksandra Mladenovic Djordjevic, Andres Lopez-Contreras, Catarina M Henriques, Colin Selman, Elisabete Ferreiro, Efstathios S Gonos, José Luis Trejo, Juhi Misra, Lene Juel Rasmussen, Sara Xapelli, Timothy Ellam, Ilaria Bellantuono

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Abstract

Over 60% of people aged over 65 are affected by multiple morbidities, which are more difficult to treat, generate increased healthcare costs and lead to poor quality of life compared to individual diseases. With the number of older people steadily increasing this presents a societal challenge. Age is the major risk factor for age-related diseases and recent research developments have led to the proposal that pharmacological interventions targeting common mechanisms of ageing may be able to delay the onset of multimorbidity. Here we review the state of the knowledge of multimorbidity, appraise the available evidence supporting the role of mechanisms of ageing in the development of the most common age-related diseases and assess potential molecules that may successfully target those key mechanisms.

Original language	English
Journal	Mechanisms of Ageing and Development
Volume	160
Pages (from-to)	69-92
Number of pages	24
ISSN	0047-6374
DOIs	https://doi.org/10.1016/j.mad.2016.09.009
Publication status	Published - 1 Dec 2016

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Interventions for age-related diseases: Shifting the paradigmFinal published version, 1.47 MBLicence: CC BY-NC-ND

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Figueira, I., Fernandes, A., Mladenovic Djordjevic, A., Lopez-Contreras, A., Henriques, C. M., Selman, C., Ferreiro, E., Gonos, E. S., Trejo, J. L., Misra, J., Rasmussen, L. J., Xapelli, S., Ellam, T., & Bellantuono, I. (2016). Interventions for age-related diseases: Shifting the paradigm. Mechanisms of Ageing and Development, 160, 69-92. https://doi.org/10.1016/j.mad.2016.09.009

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T1 - Interventions for age-related diseases

T2 - Shifting the paradigm

AU - Figueira, Inês

AU - Fernandes, Adelaide

AU - Mladenovic Djordjevic, Aleksandra

AU - Lopez-Contreras, Andres

AU - Henriques, Catarina M

AU - Selman, Colin

AU - Ferreiro, Elisabete

AU - Gonos, Efstathios S

AU - Trejo, José Luis

AU - Misra, Juhi

AU - Rasmussen, Lene Juel

AU - Xapelli, Sara

AU - Ellam, Timothy

AU - Bellantuono, Ilaria

PY - 2016/12/1

Y1 - 2016/12/1

N2 - Over 60% of people aged over 65 are affected by multiple morbidities, which are more difficult to treat, generate increased healthcare costs and lead to poor quality of life compared to individual diseases. With the number of older people steadily increasing this presents a societal challenge. Age is the major risk factor for age-related diseases and recent research developments have led to the proposal that pharmacological interventions targeting common mechanisms of ageing may be able to delay the onset of multimorbidity. Here we review the state of the knowledge of multimorbidity, appraise the available evidence supporting the role of mechanisms of ageing in the development of the most common age-related diseases and assess potential molecules that may successfully target those key mechanisms.

AB - Over 60% of people aged over 65 are affected by multiple morbidities, which are more difficult to treat, generate increased healthcare costs and lead to poor quality of life compared to individual diseases. With the number of older people steadily increasing this presents a societal challenge. Age is the major risk factor for age-related diseases and recent research developments have led to the proposal that pharmacological interventions targeting common mechanisms of ageing may be able to delay the onset of multimorbidity. Here we review the state of the knowledge of multimorbidity, appraise the available evidence supporting the role of mechanisms of ageing in the development of the most common age-related diseases and assess potential molecules that may successfully target those key mechanisms.

U2 - 10.1016/j.mad.2016.09.009

DO - 10.1016/j.mad.2016.09.009

M3 - Review

C2 - 27693441

SN - 0047-6374

VL - 160

SP - 69

EP - 92

JO - Mechanisms of Ageing and Development

JF - Mechanisms of Ageing and Development

ER -

Interventions for age-related diseases: Shifting the paradigm

Abstract

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