Research output per year
Research output per year
Personal profile
Primary fields of research
DNA damage and DNA repair, Replication Stress, Mouse models of cancer and ageing.
Current research
Exploring the impact of Replication Stress on Ageing and Cancer This project is financed from the Danish National Research Program “Sapere Aude – DFF Starting Grant”
Identification of novel targets for the BRCA1 ubiquitin ligase activity. This project is funded by a KBVU Project from the Danish Cancer Society.
Chromosomal Common Fragile Sites: Unravelling their biological functions and the basis of their instability This project is funded by the European Research Council (ERC-2015-StG)
Participants: Andres J Lopez-Contreras, group leader Alexandra Avram, lab technician Mauro Sbroggió, postdoc Stephanie Munk, postdoc Eliene Albers, PhD student David Pladevall Morera, PhD student
If you are interested in joining our lab, we want to hear about you and your ideas! Please, send an e-mail to [email protected] including your CV and a motivation letter.
Collaborators
Dr. Oscar Fernandez-Capetillo, Spanish National Cancer Research Center (CNIO), Madrid, Spain
Prof. Ian D. Hickson, Department of Cellular and Molecular Medicine, University of Copenhagen, Denmark
Prof. Rafael Peñafiel-Garcia, University of Murcia, Spain
Dr. Javier Muñoz, Spanish National Cancer Research Center (CNIO), Madrid, Spain
Dr. Andre Nussenzweig, National Cancer Institute, National Institutes of Health, Bethesda, USA
Dr. Jeremy A. Daniel, Center for Protein Research, University of Copenhagen, Denmark.
Jesper V. Olsen, CPR, Copenhagen, Denmark (mass spectrometry for quantitative proteomics)
Lene J. Rasmussen, CEHA, Copenhagen, Denmark (genomic instability and mitochondrial function)
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Keywords
- Faculty of Health and Medical Sciences
- DNA damage
- DNA repair
- Replication Stress
- Mouse models of cancer and ageing
Fingerprint
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- 12 Similar Profiles
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Proteomic characterization of chromosomal common fragile site (CFS)-associated proteins uncovers ATRX as a regulator of CFS stability
Pladevall-Morera, D., Munk, S., Ingham, A., Garribba, L., Albers, E., Liu, Y., Olsen, J. V. & Lopez-Contreras, A. J., 1 Sept 2019, In: Nucleic Acids Research. 47, 15, p. 8004-8018 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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TIAR marks nuclear G2/M transition granules and restricts CDK1 activity under replication stress
Lafarga, V., Sung, H-M., Haneke, K., Roessig, L., Pauleau, A-L., Bruer, M., Rodriguez-Acebes, S., Lopez-Contreras, A. J., Gruss, O. J., Erhardt, S., Mendez, J., Fernandez-Capetillo, O. & Stoecklin, G., Jan 2019, In: EMBO Reports. 20, 1Research output: Contribution to journal › Journal article › Research › peer-review
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Loss of PICH Results in Chromosomal Instability, p53 Activation, and Embryonic Lethality
Albers, E., Sbroggiò, M., Pladevall-Morera, D., Bizard, A. H., Avram, A., Gonzalez, P., Martin-Gonzalez, J., Hickson, I. D. & Lopez-Contreras, A. J., 2018, In: Cell Reports. 24, 12, p. 3274-3284 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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New insights of polyamine metabolism in testicular physiology: A role of ornithine decarboxylase antizyme inhibitor 2 (AZIN2) in the modulation of testosterone levels and sperm motility
Lambertos, A., Ramos-Molina, B., López-Contreras, A. J., Cremades, A. & Peñafiel, R., 2018, In: PLoS ONE. 13, 12, 22 p., e0209202.Research output: Contribution to journal › Journal article › Research › peer-review
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The mouse Gm853 gene encodes a novel enzyme: Leucine decarboxylase
Lambertos, A., Ramos-Molina, B., Cerezo, D., López-Contreras, A. J. & Peñafiel, R., Mar 2018, In: Biochimica et Biophysica Acta - General Subjects. 1862, 3, p. 365-376 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A simple DNA recombination screening method by RT-PCR as an alternative to Southern blot
Albers, E., Sbroggiò, M., Martin Gonzalez, J., Avram, A. I., Munk, S. & Lopez-Contreras, A. J., 1 Jun 2017, In: Transgenic Research. 26, 3, p. 429-434 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Proteomics Reveals Global Regulation of Protein SUMOylation by ATM and ATR Kinases during Replication Stress
Munk, S., Sigurðsson, J. O., Xiao, Z., Batth, T. S., Franciosa, G., von Stechow, L., Lopez-Contreras, A. J., Vertegaal, A. C. O. & Olsen, J. V., 2017, In: Cell Reports. 21, 2, p. 546-558 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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DNA Damage Signaling Instructs Polyploid Macrophage Fate in Granulomas
Herrtwich, L., Nanda, I., Evangelou, K., Nikolova, T., Horn, V., Sagar, Erny, D., Stefanowski, J., Rogell, L., Klein, C., Gharun, K., Follo, M., Seidl, M., Kremer, B., Muenke, N., Senges, J., Fliegauf, M., Aschman, T., Pfeifer, D., Sarrazin, S., & 18 others, 17 Nov 2016, In: Cell. 167, 5, p. 1264–1280.e18Research output: Contribution to journal › Journal article › Research › peer-review