International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors

Jörg Hamann; Gabriela Aust; Demet Araç; Felix B Engel; Caroline Formstone; Robert Fredriksson; Randy A Hall; Breanne L Harty; Christiane Kirchhoff; Barbara Knapp; Arunkumar Krishnan; Ines Liebscher; Hsi-Hsien Lin; David C Martinelli; Kelly R Monk; Miriam Cornelia Peeters; Xianhua Piao; Simone Prömel; Torsten Schöneberg; Thue W Schwartz; Kathleen Singer; Martin Stacey; Yuri A Ushkaryov; Mario Vallon; Uwe Wolfrum; Mathew W Wright; Lei Xu; Tobias Langenhan; Helgi B Schiöth

doi:10.1124/pr.114.009647

International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors

Jörg Hamann, Gabriela Aust, Demet Araç, Felix B Engel, Caroline Formstone, Robert Fredriksson, Randy A Hall, Breanne L Harty, Christiane Kirchhoff, Barbara Knapp, Arunkumar Krishnan, Ines Liebscher, Hsi-Hsien Lin, David C Martinelli, Kelly R Monk, Miriam Cornelia Peeters, Xianhua Piao, Simone Prömel, Torsten Schöneberg, Thue W SchwartzKathleen Singer, Martin Stacey, Yuri A Ushkaryov, Mario Vallon, Uwe Wolfrum, Mathew W Wright, Lei Xu, Tobias Langenhan, Helgi B Schiöth

Department of Neuroscience

204 Citations (Scopus)

Abstract

The Adhesion family forms a large branch of the pharmacologically important superfamily of G protein-coupled receptors (GPCRs). As Adhesion GPCRs increasingly receive attention from a wide spectrum of biomedical fields, the Adhesion GPCR Consortium, together with the International Union of Basic and Clinical Pharmacology Committee on Receptor Nomenclature and Drug Classification, proposes a unified nomenclature for Adhesion GPCRs. The new names have ADGR as common dominator followed by a letter and a number to denote each subfamily and subtype, respectively. The new names, with old and alternative names within parentheses, are: ADGRA1 (GPR123), ADGRA2 (GPR124), ADGRA3 (GPR125), ADGRB1 (BAI1), ADGRB2 (BAI2), ADGRB3 (BAI3), ADGRC1 (CELSR1), ADGRC2 (CELSR2), ADGRC3 (CELSR3), ADGRD1 (GPR133), ADGRD2 (GPR144), ADGRE1 (EMR1, F4/80), ADGRE2 (EMR2), ADGRE3 (EMR3), ADGRE4 (EMR4), ADGRE5 (CD97), ADGRF1 (GPR110), ADGRF2 (GPR111), ADGRF3 (GPR113), ADGRF4 (GPR115), ADGRF5 (GPR116, Ig-Hepta), ADGRG1 (GPR56), ADGRG2 (GPR64, HE6), ADGRG3 (GPR97), ADGRG4 (GPR112), ADGRG5 (GPR114), ADGRG6 (GPR126), ADGRG7 (GPR128), ADGRL1 (latrophilin-1, CIRL-1, CL1), ADGRL2 (latrophilin-2, CIRL-2, CL2), ADGRL3 (latrophilin-3, CIRL-3, CL3), ADGRL4 (ELTD1, ETL), and ADGRV1 (VLGR1, GPR98). This review covers all major biologic aspects of Adhesion GPCRs, including evolutionary origins, interaction partners, signaling, expression, physiologic functions, and therapeutic potential.

Original language	English
Journal	Pharmacological Reviews
Volume	67
Issue number	2
Pages (from-to)	338-67
Number of pages	30
ISSN	0031-6997
DOIs	https://doi.org/10.1124/pr.114.009647
Publication status	Published - 23 Feb 2015

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Hamann, J., Aust, G., Araç, D., Engel, F. B., Formstone, C., Fredriksson, R., Hall, R. A., Harty, B. L., Kirchhoff, C., Knapp, B., Krishnan, A., Liebscher, I., Lin, H.-H., Martinelli, D. C., Monk, K. R., Cornelia Peeters, M., Piao, X., Prömel, S., Schöneberg, T., ... Schiöth, H. B. (2015). International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. Pharmacological Reviews, 67(2), 338-67. https://doi.org/10.1124/pr.114.009647

Hamann, J, Aust, G, Araç, D, Engel, FB, Formstone, C, Fredriksson, R, Hall, RA, Harty, BL, Kirchhoff, C, Knapp, B, Krishnan, A, Liebscher, I, Lin, H-H, Martinelli, DC, Monk, KR, Cornelia Peeters, M, Piao, X, Prömel, S, Schöneberg, T, Schwartz, TW, Singer, K, Stacey, M, Ushkaryov, YA, Vallon, M, Wolfrum, U, Wright, MW, Xu, L, Langenhan, T & Schiöth, HB 2015, 'International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors', Pharmacological Reviews, vol. 67, no. 2, pp. 338-67. https://doi.org/10.1124/pr.114.009647

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title = "International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors",

abstract = "The Adhesion family forms a large branch of the pharmacologically important superfamily of G protein-coupled receptors (GPCRs). As Adhesion GPCRs increasingly receive attention from a wide spectrum of biomedical fields, the Adhesion GPCR Consortium, together with the International Union of Basic and Clinical Pharmacology Committee on Receptor Nomenclature and Drug Classification, proposes a unified nomenclature for Adhesion GPCRs. The new names have ADGR as common dominator followed by a letter and a number to denote each subfamily and subtype, respectively. The new names, with old and alternative names within parentheses, are: ADGRA1 (GPR123), ADGRA2 (GPR124), ADGRA3 (GPR125), ADGRB1 (BAI1), ADGRB2 (BAI2), ADGRB3 (BAI3), ADGRC1 (CELSR1), ADGRC2 (CELSR2), ADGRC3 (CELSR3), ADGRD1 (GPR133), ADGRD2 (GPR144), ADGRE1 (EMR1, F4/80), ADGRE2 (EMR2), ADGRE3 (EMR3), ADGRE4 (EMR4), ADGRE5 (CD97), ADGRF1 (GPR110), ADGRF2 (GPR111), ADGRF3 (GPR113), ADGRF4 (GPR115), ADGRF5 (GPR116, Ig-Hepta), ADGRG1 (GPR56), ADGRG2 (GPR64, HE6), ADGRG3 (GPR97), ADGRG4 (GPR112), ADGRG5 (GPR114), ADGRG6 (GPR126), ADGRG7 (GPR128), ADGRL1 (latrophilin-1, CIRL-1, CL1), ADGRL2 (latrophilin-2, CIRL-2, CL2), ADGRL3 (latrophilin-3, CIRL-3, CL3), ADGRL4 (ELTD1, ETL), and ADGRV1 (VLGR1, GPR98). This review covers all major biologic aspects of Adhesion GPCRs, including evolutionary origins, interaction partners, signaling, expression, physiologic functions, and therapeutic potential.",

author = "J{\"o}rg Hamann and Gabriela Aust and Demet Ara{\c c} and Engel, {Felix B} and Caroline Formstone and Robert Fredriksson and Hall, {Randy A} and Harty, {Breanne L} and Christiane Kirchhoff and Barbara Knapp and Arunkumar Krishnan and Ines Liebscher and Hsi-Hsien Lin and Martinelli, {David C} and Monk, {Kelly R} and {Cornelia Peeters}, Miriam and Xianhua Piao and Simone Pr{\"o}mel and Torsten Sch{\"o}neberg and Schwartz, {Thue W} and Kathleen Singer and Martin Stacey and Ushkaryov, {Yuri A} and Mario Vallon and Uwe Wolfrum and Wright, {Mathew W} and Lei Xu and Tobias Langenhan and Schi{\"o}th, {Helgi B}",

note = "Copyright {\textcopyright} 2015 by The American Society for Pharmacology and Experimental Therapeutics.",

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T1 - International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors

AU - Hamann, Jörg

AU - Aust, Gabriela

AU - Araç, Demet

AU - Engel, Felix B

AU - Formstone, Caroline

AU - Fredriksson, Robert

AU - Hall, Randy A

AU - Harty, Breanne L

AU - Kirchhoff, Christiane

AU - Knapp, Barbara

AU - Krishnan, Arunkumar

AU - Liebscher, Ines

AU - Lin, Hsi-Hsien

AU - Martinelli, David C

AU - Monk, Kelly R

AU - Cornelia Peeters, Miriam

AU - Piao, Xianhua

AU - Prömel, Simone

AU - Schöneberg, Torsten

AU - Schwartz, Thue W

AU - Singer, Kathleen

AU - Stacey, Martin

AU - Ushkaryov, Yuri A

AU - Vallon, Mario

AU - Wolfrum, Uwe

AU - Wright, Mathew W

AU - Xu, Lei

AU - Langenhan, Tobias

AU - Schiöth, Helgi B

PY - 2015/2/23

Y1 - 2015/2/23

N2 - The Adhesion family forms a large branch of the pharmacologically important superfamily of G protein-coupled receptors (GPCRs). As Adhesion GPCRs increasingly receive attention from a wide spectrum of biomedical fields, the Adhesion GPCR Consortium, together with the International Union of Basic and Clinical Pharmacology Committee on Receptor Nomenclature and Drug Classification, proposes a unified nomenclature for Adhesion GPCRs. The new names have ADGR as common dominator followed by a letter and a number to denote each subfamily and subtype, respectively. The new names, with old and alternative names within parentheses, are: ADGRA1 (GPR123), ADGRA2 (GPR124), ADGRA3 (GPR125), ADGRB1 (BAI1), ADGRB2 (BAI2), ADGRB3 (BAI3), ADGRC1 (CELSR1), ADGRC2 (CELSR2), ADGRC3 (CELSR3), ADGRD1 (GPR133), ADGRD2 (GPR144), ADGRE1 (EMR1, F4/80), ADGRE2 (EMR2), ADGRE3 (EMR3), ADGRE4 (EMR4), ADGRE5 (CD97), ADGRF1 (GPR110), ADGRF2 (GPR111), ADGRF3 (GPR113), ADGRF4 (GPR115), ADGRF5 (GPR116, Ig-Hepta), ADGRG1 (GPR56), ADGRG2 (GPR64, HE6), ADGRG3 (GPR97), ADGRG4 (GPR112), ADGRG5 (GPR114), ADGRG6 (GPR126), ADGRG7 (GPR128), ADGRL1 (latrophilin-1, CIRL-1, CL1), ADGRL2 (latrophilin-2, CIRL-2, CL2), ADGRL3 (latrophilin-3, CIRL-3, CL3), ADGRL4 (ELTD1, ETL), and ADGRV1 (VLGR1, GPR98). This review covers all major biologic aspects of Adhesion GPCRs, including evolutionary origins, interaction partners, signaling, expression, physiologic functions, and therapeutic potential.

AB - The Adhesion family forms a large branch of the pharmacologically important superfamily of G protein-coupled receptors (GPCRs). As Adhesion GPCRs increasingly receive attention from a wide spectrum of biomedical fields, the Adhesion GPCR Consortium, together with the International Union of Basic and Clinical Pharmacology Committee on Receptor Nomenclature and Drug Classification, proposes a unified nomenclature for Adhesion GPCRs. The new names have ADGR as common dominator followed by a letter and a number to denote each subfamily and subtype, respectively. The new names, with old and alternative names within parentheses, are: ADGRA1 (GPR123), ADGRA2 (GPR124), ADGRA3 (GPR125), ADGRB1 (BAI1), ADGRB2 (BAI2), ADGRB3 (BAI3), ADGRC1 (CELSR1), ADGRC2 (CELSR2), ADGRC3 (CELSR3), ADGRD1 (GPR133), ADGRD2 (GPR144), ADGRE1 (EMR1, F4/80), ADGRE2 (EMR2), ADGRE3 (EMR3), ADGRE4 (EMR4), ADGRE5 (CD97), ADGRF1 (GPR110), ADGRF2 (GPR111), ADGRF3 (GPR113), ADGRF4 (GPR115), ADGRF5 (GPR116, Ig-Hepta), ADGRG1 (GPR56), ADGRG2 (GPR64, HE6), ADGRG3 (GPR97), ADGRG4 (GPR112), ADGRG5 (GPR114), ADGRG6 (GPR126), ADGRG7 (GPR128), ADGRL1 (latrophilin-1, CIRL-1, CL1), ADGRL2 (latrophilin-2, CIRL-2, CL2), ADGRL3 (latrophilin-3, CIRL-3, CL3), ADGRL4 (ELTD1, ETL), and ADGRV1 (VLGR1, GPR98). This review covers all major biologic aspects of Adhesion GPCRs, including evolutionary origins, interaction partners, signaling, expression, physiologic functions, and therapeutic potential.

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DO - 10.1124/pr.114.009647

M3 - Journal article

C2 - 25713288

SN - 0031-6997

VL - 67

SP - 338

EP - 367

JO - Pharmacological Reviews

JF - Pharmacological Reviews

IS - 2

ER -

International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors

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