Intermittent preventive therapy in pregnancy and incidence of low birth weight in malaria-endemic countries

Jordan E. Cates; Daniel Westreich; Holger W. Unger; Melissa Bauserman; Linda Adair; Stephen R. Cole; Steven Meshnick; Stephen J. Rogerson; The Maternal Malaria and Malnutrition (M3) Initiative; V. Briand; N. Fievet; I. Valea; H. Tinto; U. D'Alessandro; S. H. Landis; A. Lartey; K. G. Dewey; F. O. TerKuile; S. Dellicour; A. M. Van Eijk; M. Desai; M. Owidhi; A. L'Ianziva; G. Aol; V. Were; S. Kariuki; J. Ayisi; D. J. Terlouw; M. Madanitsa; V. Mwapasa; K. Maleta; P. Ashorn; I. Mueller; D. Stanisic; C. Schmiegelow; J. P.A. Lusingu

doi:10.2105/AJPH.2017.304251

Intermittent preventive therapy in pregnancy and incidence of low birth weight in malaria-endemic countries

Jordan E. Cates^*, Daniel Westreich, Holger W. Unger, Melissa Bauserman, Linda Adair, Stephen R. Cole, Steven Meshnick, Stephen J. Rogerson, The Maternal Malaria and Malnutrition (M3) Initiative, V. Briand, N. Fievet, I. Valea, H. Tinto, U. D'Alessandro, S. H. Landis, A. Lartey, K. G. Dewey, F. O. TerKuile, S. Dellicour, A. M. Van EijkM. Desai, M. Owidhi, A. L'Ianziva, G. Aol, V. Were, S. Kariuki, J. Ayisi, D. J. Terlouw, M. Madanitsa, V. Mwapasa, K. Maleta, P. Ashorn, I. Mueller, D. Stanisic, C. Schmiegelow, J. P.A. Lusingu

^*Corresponding author for this work

4 Citations (Scopus)

Abstract

Objectives. To estimate the impact of hypothetical antimalarial and nutritional interventions (which reduce the prevalence of low midupper arm circumference [MUAC]) on the incidence of low birth weight (LBW). Methods. We analyzed data from 14 633 pregnancies from 13 studies conducted across Africa and the Western Pacific from 1996 to 2015. We calculated population intervention effects for increasing intermittent preventive therapy in pregnancy (IPTp), full coverage with bed nets, reduction in malaria infection at delivery, and reductions in the prevalence of low MUAC. Results. We estimated that, compared with observed IPTp use, administering 3 or more doses of IPTp to all women would decrease the incidence of LBW from 9.9% to 6.9% (risk difference = 3.0%; 95% confidence interval = 1.7%, 4.0%). The intervention effects for eliminating malaria at delivery, increasing bed net ownership, and decreasing low MUAC prevalence were all modest. Conclusions. Increasing IPTp uptake to at least 3 doses could decrease the incidence of LBW in malaria-endemic countries. The impact of IPTp on LBW was greater than the effect of prevention of malaria, consistent with a nonmalarial effect of IPTp, measurement error, or selection bias.

Original language	English
Journal	American Journal of Public Health
Volume	108
Issue number	3
Pages (from-to)	399-406
Number of pages	8
ISSN	0090-0036
DOIs	https://doi.org/10.2105/AJPH.2017.304251
Publication status	Published - Mar 2018

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Cates, J. E., Westreich, D., Unger, H. W., Bauserman, M., Adair, L., Cole, S. R., Meshnick, S., Rogerson, S. J., The Maternal Malaria and Malnutrition (M3) Initiative, Briand, V., Fievet, N., Valea, I., Tinto, H., D'Alessandro, U., Landis, S. H., Lartey, A., Dewey, K. G., TerKuile, F. O., Dellicour, S., ... Lusingu, J. P. A. (2018). Intermittent preventive therapy in pregnancy and incidence of low birth weight in malaria-endemic countries. American Journal of Public Health, 108(3), 399-406. https://doi.org/10.2105/AJPH.2017.304251

Cates, JE, Westreich, D, Unger, HW, Bauserman, M, Adair, L, Cole, SR, Meshnick, S, Rogerson, SJ, The Maternal Malaria and Malnutrition (M3) Initiative, Briand, V, Fievet, N, Valea, I, Tinto, H, D'Alessandro, U, Landis, SH, Lartey, A, Dewey, KG, TerKuile, FO, Dellicour, S, Van Eijk, AM, Desai, M, Owidhi, M, L'Ianziva, A, Aol, G, Were, V, Kariuki, S, Ayisi, J, Terlouw, DJ, Madanitsa, M, Mwapasa, V, Maleta, K, Ashorn, P, Mueller, I, Stanisic, D, Schmiegelow, C & Lusingu, JPA 2018, 'Intermittent preventive therapy in pregnancy and incidence of low birth weight in malaria-endemic countries', American Journal of Public Health, vol. 108, no. 3, pp. 399-406. https://doi.org/10.2105/AJPH.2017.304251

@article{f0770b0aa12149339d929876f28a1f90,

title = "Intermittent preventive therapy in pregnancy and incidence of low birth weight in malaria-endemic countries",

abstract = "Objectives. To estimate the impact of hypothetical antimalarial and nutritional interventions (which reduce the prevalence of low midupper arm circumference [MUAC]) on the incidence of low birth weight (LBW). Methods. We analyzed data from 14 633 pregnancies from 13 studies conducted across Africa and the Western Pacific from 1996 to 2015. We calculated population intervention effects for increasing intermittent preventive therapy in pregnancy (IPTp), full coverage with bed nets, reduction in malaria infection at delivery, and reductions in the prevalence of low MUAC. Results. We estimated that, compared with observed IPTp use, administering 3 or more doses of IPTp to all women would decrease the incidence of LBW from 9.9% to 6.9% (risk difference = 3.0%; 95% confidence interval = 1.7%, 4.0%). The intervention effects for eliminating malaria at delivery, increasing bed net ownership, and decreasing low MUAC prevalence were all modest. Conclusions. Increasing IPTp uptake to at least 3 doses could decrease the incidence of LBW in malaria-endemic countries. The impact of IPTp on LBW was greater than the effect of prevention of malaria, consistent with a nonmalarial effect of IPTp, measurement error, or selection bias.",

author = "Cates, {Jordan E.} and Daniel Westreich and Unger, {Holger W.} and Melissa Bauserman and Linda Adair and Cole, {Stephen R.} and Steven Meshnick and Rogerson, {Stephen J.} and {The Maternal Malaria and Malnutrition (M3) Initiative} and V. Briand and N. Fievet and I. Valea and H. Tinto and U. D'Alessandro and Landis, {S. H.} and A. Lartey and Dewey, {K. G.} and TerKuile, {F. O.} and S. Dellicour and {Van Eijk}, {A. M.} and M. Desai and M. Owidhi and A. L'Ianziva and G. Aol and V. Were and S. Kariuki and J. Ayisi and Terlouw, {D. J.} and M. Madanitsa and V. Mwapasa and K. Maleta and P. Ashorn and I. Mueller and D. Stanisic and C. Schmiegelow and Lusingu, {J. P.A.}",

year = "2018",

month = mar,

doi = "10.2105/AJPH.2017.304251",

language = "English",

volume = "108",

pages = "399--406",

journal = "American Journal of Public Health",

issn = "0090-0036",

publisher = "American Public Health Association",

number = "3",

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TY - JOUR

T1 - Intermittent preventive therapy in pregnancy and incidence of low birth weight in malaria-endemic countries

AU - Cates, Jordan E.

AU - Westreich, Daniel

AU - Unger, Holger W.

AU - Bauserman, Melissa

AU - Adair, Linda

AU - Cole, Stephen R.

AU - Meshnick, Steven

AU - Rogerson, Stephen J.

AU - The Maternal Malaria and Malnutrition (M3) Initiative

AU - Briand, V.

AU - Fievet, N.

AU - Valea, I.

AU - Tinto, H.

AU - D'Alessandro, U.

AU - Landis, S. H.

AU - Lartey, A.

AU - Dewey, K. G.

AU - TerKuile, F. O.

AU - Dellicour, S.

AU - Van Eijk, A. M.

AU - Desai, M.

AU - Owidhi, M.

AU - L'Ianziva, A.

AU - Aol, G.

AU - Were, V.

AU - Kariuki, S.

AU - Ayisi, J.

AU - Terlouw, D. J.

AU - Madanitsa, M.

AU - Mwapasa, V.

AU - Maleta, K.

AU - Ashorn, P.

AU - Mueller, I.

AU - Stanisic, D.

AU - Schmiegelow, C.

AU - Lusingu, J. P.A.

PY - 2018/3

Y1 - 2018/3

N2 - Objectives. To estimate the impact of hypothetical antimalarial and nutritional interventions (which reduce the prevalence of low midupper arm circumference [MUAC]) on the incidence of low birth weight (LBW). Methods. We analyzed data from 14 633 pregnancies from 13 studies conducted across Africa and the Western Pacific from 1996 to 2015. We calculated population intervention effects for increasing intermittent preventive therapy in pregnancy (IPTp), full coverage with bed nets, reduction in malaria infection at delivery, and reductions in the prevalence of low MUAC. Results. We estimated that, compared with observed IPTp use, administering 3 or more doses of IPTp to all women would decrease the incidence of LBW from 9.9% to 6.9% (risk difference = 3.0%; 95% confidence interval = 1.7%, 4.0%). The intervention effects for eliminating malaria at delivery, increasing bed net ownership, and decreasing low MUAC prevalence were all modest. Conclusions. Increasing IPTp uptake to at least 3 doses could decrease the incidence of LBW in malaria-endemic countries. The impact of IPTp on LBW was greater than the effect of prevention of malaria, consistent with a nonmalarial effect of IPTp, measurement error, or selection bias.

AB - Objectives. To estimate the impact of hypothetical antimalarial and nutritional interventions (which reduce the prevalence of low midupper arm circumference [MUAC]) on the incidence of low birth weight (LBW). Methods. We analyzed data from 14 633 pregnancies from 13 studies conducted across Africa and the Western Pacific from 1996 to 2015. We calculated population intervention effects for increasing intermittent preventive therapy in pregnancy (IPTp), full coverage with bed nets, reduction in malaria infection at delivery, and reductions in the prevalence of low MUAC. Results. We estimated that, compared with observed IPTp use, administering 3 or more doses of IPTp to all women would decrease the incidence of LBW from 9.9% to 6.9% (risk difference = 3.0%; 95% confidence interval = 1.7%, 4.0%). The intervention effects for eliminating malaria at delivery, increasing bed net ownership, and decreasing low MUAC prevalence were all modest. Conclusions. Increasing IPTp uptake to at least 3 doses could decrease the incidence of LBW in malaria-endemic countries. The impact of IPTp on LBW was greater than the effect of prevention of malaria, consistent with a nonmalarial effect of IPTp, measurement error, or selection bias.

U2 - 10.2105/AJPH.2017.304251

DO - 10.2105/AJPH.2017.304251

M3 - Journal article

C2 - 29346002

AN - SCOPUS:85042001821

SN - 0090-0036

VL - 108

SP - 399

EP - 406

JO - American Journal of Public Health

JF - American Journal of Public Health

IS - 3

ER -

Intermittent preventive therapy in pregnancy and incidence of low birth weight in malaria-endemic countries

Abstract

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