Abstract
Background. The aim of this study was to investigate IL-6 and 25-hydroxyvitamin D (25-OH D) associations with muscle size and muscle function in dialysis patients. Methods. Patients were included in a 16-week control period followed by 16 weeks of high-intensity resistance training thrice weekly. IL-6 and 25-OH D were analysed after an over-night fast. Muscle fibre size was analysed in biopsies from m. vastus lateralis. Muscle power was tested using a Leg Extensor Power Rig. Results. Patients (n = 36) with IL-6 ≥ 6.49 pg/ml (median) were older and had decreased muscle power and a reduced protein intake (P < 0.05) compared with patients with IL-6 < 6.49 pg/ml. IL-6 was not associated with muscle fibre size. Vitamin D deficiency (25-OH D < 50 nmol/l) was present in 51% of the patients and not associated with muscle power. IL-6 remained unchanged during the training period, whilst muscle power increased by 20-23% (P < 0.001). Conclusion. Elevated IL-6 values were associated with decreased muscle power but not with decreased muscle fibre size. Half of the patients were suffering from vitamin D deficiency, which was not associated with muscle power. IL-6 was unchanged by high-intensity resistance training in dialysis patients in this study.
| Original language | English |
|---|---|
| Article number | 176190 |
| Journal | Journal of Biomedicine and Biotechnology |
| Volume | 2014 |
| Number of pages | 8 |
| ISSN | 1110-7243 |
| DOIs | |
| Publication status | Published - 2014 |
Keywords
- Female
- Humans
- Interleukin-6
- Male
- Middle Aged
- Muscle Strength
- Muscle, Skeletal
- Nephritis
- Organ Size
- Renal Insufficiency, Chronic
- Resistance Training
- Treatment Outcome
- Vitamin D