Interleukin-4 and 13 induce the expression and release of monocyte chemoattractant protein 1, interleukin-6 and stem cell factor from human detrusor smooth muscle cells: synergy with interleukin-1beta and tumor necrosis factor-alpha

Kirsten Bouchelouche; Lars Andresen; Susana Alvarez; Jorgen Nordling; Ole Haagen Nielsen; Pierre Bouchelouche

doi:10.1016/S0022-5347(05)00167-9

Interleukin-4 and 13 induce the expression and release of monocyte chemoattractant protein 1, interleukin-6 and stem cell factor from human detrusor smooth muscle cells: synergy with interleukin-1beta and tumor necrosis factor-alpha

Kirsten Bouchelouche, Lars Andresen, Susana Alvarez, Jorgen Nordling, Ole Haagen Nielsen, Pierre Bouchelouche

Department of Clinical Medicine

19 Citations (Scopus)

Abstract

Interstitial cystitis is characterized by an increased number of activated MCs in the detrusor muscle. However, to our knowledge the factors that influence the anatomical relationship between MCs and HDSMCs are unknown. MCP-1, IL-6 and SCF have a critical role in the regulation of MC development, signaling and function. We investigated whether HDSMCs are capable of expressing and releasing MCP-1, IL-6 and SCF in response to IL-4, IL-13, IL-1beta and tumor necrosis factor-alpha.

Original language	English
Journal	Journal of Urology
Volume	175
Issue number	2
Pages (from-to)	760-5
Number of pages	6
ISSN	0022-5347
DOIs	https://doi.org/10.1016/S0022-5347(05)00167-9
Publication status	Published - 2006

Keywords

Cells, Cultured
Chemokine CCL2
Humans
Interleukin-1
Interleukin-13
Interleukin-4
Interleukin-6
Muscle, Smooth
Stem Cell Factor
Tumor Necrosis Factor-alpha

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Bouchelouche, K., Andresen, L., Alvarez, S., Nordling, J., Nielsen, O. H., & Bouchelouche, P. (2006). Interleukin-4 and 13 induce the expression and release of monocyte chemoattractant protein 1, interleukin-6 and stem cell factor from human detrusor smooth muscle cells: synergy with interleukin-1beta and tumor necrosis factor-alpha. Journal of Urology, 175(2), 760-5. https://doi.org/10.1016/S0022-5347(05)00167-9

Interleukin-4 and 13 induce the expression and release of monocyte chemoattractant protein 1, interleukin-6 and stem cell factor from human detrusor smooth muscle cells: synergy with interleukin-1beta and tumor necrosis factor-alpha. / Bouchelouche, Kirsten; Andresen, Lars; Alvarez, Susana et al.

In: Journal of Urology, Vol. 175, No. 2, 2006, p. 760-5.

Research output: Contribution to journal › Journal article › Research › peer-review

Bouchelouche, K, Andresen, L, Alvarez, S, Nordling, J, Nielsen, OH & Bouchelouche, P 2006, 'Interleukin-4 and 13 induce the expression and release of monocyte chemoattractant protein 1, interleukin-6 and stem cell factor from human detrusor smooth muscle cells: synergy with interleukin-1beta and tumor necrosis factor-alpha', Journal of Urology, vol. 175, no. 2, pp. 760-5. https://doi.org/10.1016/S0022-5347(05)00167-9

Bouchelouche K, Andresen L, Alvarez S, Nordling J, Nielsen OH, Bouchelouche P. Interleukin-4 and 13 induce the expression and release of monocyte chemoattractant protein 1, interleukin-6 and stem cell factor from human detrusor smooth muscle cells: synergy with interleukin-1beta and tumor necrosis factor-alpha. Journal of Urology. 2006;175(2):760-5. doi: 10.1016/S0022-5347(05)00167-9

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abstract = "Interstitial cystitis is characterized by an increased number of activated MCs in the detrusor muscle. However, to our knowledge the factors that influence the anatomical relationship between MCs and HDSMCs are unknown. MCP-1, IL-6 and SCF have a critical role in the regulation of MC development, signaling and function. We investigated whether HDSMCs are capable of expressing and releasing MCP-1, IL-6 and SCF in response to IL-4, IL-13, IL-1beta and tumor necrosis factor-alpha.",

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AU - Andresen, Lars

AU - Alvarez, Susana

AU - Nordling, Jorgen

AU - Nielsen, Ole Haagen

AU - Bouchelouche, Pierre

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KW - Cells, Cultured

KW - Chemokine CCL2

KW - Humans

KW - Interleukin-1

KW - Interleukin-13

KW - Interleukin-4

KW - Interleukin-6

KW - Muscle, Smooth

KW - Stem Cell Factor

KW - Tumor Necrosis Factor-alpha

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