Interference of Pseudomonas aeruginosa signalling and biofilm formation for infection control

Thomas Bjarnsholt; Tim Tolker-Nielsen; Niels Høiby; Michael Givskov

doi:10.1017/S1462399410001420

Interference of Pseudomonas aeruginosa signalling and biofilm formation for infection control

Thomas Bjarnsholt, Tim Tolker-Nielsen, Niels Høiby, Michael Givskov

Department of Immunology and Microbiology

79 Citations (Scopus)

Abstract

Pseudomonas aeruginosa is the best described bacterium with regards to quorum sensing (QS), in vitro biofilm formation and the development of antibiotic tolerance. Biofilms composed of P. aeruginosa are thought to be the underlying cause of many chronic infections, including those in wounds and in the lungs of patients with cystic fibrosis. In this review, we provide an overview of the molecular mechanisms involved in QS, QS-enabled virulence, biofilm formation and biofilm-enabled antibiotic tolerance. We now have substantial knowledge of the multicellular behaviour of P. aeruginosa in vitro. A major task for the future is to investigate how such in vitro data correlate with the in vivo behaviour of P. aeruginosa, and how to treat chronic infections of this bacterium in patients.

Original language	English
Journal	Expert Reviews in Molecular Medicine
Volume	12
Pages (from-to)	e11
Number of pages	18
ISSN	1462-3994
DOIs	https://doi.org/10.1017/S1462399410001420
Publication status	Published - Feb 2010

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title = "Interference of Pseudomonas aeruginosa signalling and biofilm formation for infection control",

abstract = "Pseudomonas aeruginosa is the best described bacterium with regards to quorum sensing (QS), in vitro biofilm formation and the development of antibiotic tolerance. Biofilms composed of P. aeruginosa are thought to be the underlying cause of many chronic infections, including those in wounds and in the lungs of patients with cystic fibrosis. In this review, we provide an overview of the molecular mechanisms involved in QS, QS-enabled virulence, biofilm formation and biofilm-enabled antibiotic tolerance. We now have substantial knowledge of the multicellular behaviour of P. aeruginosa in vitro. A major task for the future is to investigate how such in vitro data correlate with the in vivo behaviour of P. aeruginosa, and how to treat chronic infections of this bacterium in patients.",

author = "Thomas Bjarnsholt and Tim Tolker-Nielsen and Niels H{\o}iby and Michael Givskov",

note = "Keywords: Animals; Biofilms; Chronic Disease; Humans; Pseudomonas Infections; Pseudomonas aeruginosa; Signal Transduction",

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AU - Bjarnsholt, Thomas

AU - Tolker-Nielsen, Tim

AU - Høiby, Niels

AU - Givskov, Michael

N1 - Keywords: Animals; Biofilms; Chronic Disease; Humans; Pseudomonas Infections; Pseudomonas aeruginosa; Signal Transduction

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N2 - Pseudomonas aeruginosa is the best described bacterium with regards to quorum sensing (QS), in vitro biofilm formation and the development of antibiotic tolerance. Biofilms composed of P. aeruginosa are thought to be the underlying cause of many chronic infections, including those in wounds and in the lungs of patients with cystic fibrosis. In this review, we provide an overview of the molecular mechanisms involved in QS, QS-enabled virulence, biofilm formation and biofilm-enabled antibiotic tolerance. We now have substantial knowledge of the multicellular behaviour of P. aeruginosa in vitro. A major task for the future is to investigate how such in vitro data correlate with the in vivo behaviour of P. aeruginosa, and how to treat chronic infections of this bacterium in patients.

AB - Pseudomonas aeruginosa is the best described bacterium with regards to quorum sensing (QS), in vitro biofilm formation and the development of antibiotic tolerance. Biofilms composed of P. aeruginosa are thought to be the underlying cause of many chronic infections, including those in wounds and in the lungs of patients with cystic fibrosis. In this review, we provide an overview of the molecular mechanisms involved in QS, QS-enabled virulence, biofilm formation and biofilm-enabled antibiotic tolerance. We now have substantial knowledge of the multicellular behaviour of P. aeruginosa in vitro. A major task for the future is to investigate how such in vitro data correlate with the in vivo behaviour of P. aeruginosa, and how to treat chronic infections of this bacterium in patients.

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DO - 10.1017/S1462399410001420

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SN - 1462-3994

VL - 12

SP - e11

JO - Expert Reviews in Molecular Medicine

JF - Expert Reviews in Molecular Medicine

ER -

Interference of Pseudomonas aeruginosa signalling and biofilm formation for infection control

Abstract

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