Interconversion between Anticipatory and Active GID E3 Ubiquitin Ligase Conformations via Metabolically Driven Substrate Receptor Assembly

Shuai Qiao; Christine R Langlois; Jakub Chrustowicz; Dawafuti Sherpa; Ozge Karayel; Fynn M Hansen; Viola Beier; Susanne von Gronau; Daniel Bollschweiler; Tillman Schäfer; Arno F Alpi; Matthias Mann; J Rajan Prabu; Brenda A Schulman

doi:10.1016/j.molcel.2019.10.009

Interconversion between Anticipatory and Active GID E3 Ubiquitin Ligase Conformations via Metabolically Driven Substrate Receptor Assembly

Shuai Qiao, Christine R Langlois, Jakub Chrustowicz, Dawafuti Sherpa, Ozge Karayel, Fynn M Hansen, Viola Beier, Susanne von Gronau, Daniel Bollschweiler, Tillman Schäfer, Arno F Alpi, Matthias Mann, J Rajan Prabu, Brenda A Schulman

12 Citations (Scopus)

Abstract

Stunning structural intricacies of the yeast GID system, now revealed more than 25 years since the discovery of glucose-induced degradation and of a protein's N terminus serving as a degron, provide a blueprint for a family of multisubunit E3s regulated through assembly with interchangeable substrate receptors induced by distinct environmental perturbations.

Original language	English
Journal	Molecular Cell
ISSN	1097-2765
DOIs	https://doi.org/10.1016/j.molcel.2019.10.009
Publication status	Published - 2 Jan 2020
Externally published	Yes

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http://www.cell.com/article/S1097276519307695/pdf

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Qiao, S., Langlois, C. R., Chrustowicz, J., Sherpa, D., Karayel, O., Hansen, F. M., Beier, V., von Gronau, S., Bollschweiler, D., Schäfer, T., Alpi, A. F., Mann, M., Prabu, J. R., & Schulman, B. A. (2020). Interconversion between Anticipatory and Active GID E3 Ubiquitin Ligase Conformations via Metabolically Driven Substrate Receptor Assembly. Molecular Cell. https://doi.org/10.1016/j.molcel.2019.10.009

Qiao, S, Langlois, CR, Chrustowicz, J, Sherpa, D, Karayel, O, Hansen, FM, Beier, V, von Gronau, S, Bollschweiler, D, Schäfer, T, Alpi, AF, Mann, M, Prabu, JR & Schulman, BA 2020, 'Interconversion between Anticipatory and Active GID E3 Ubiquitin Ligase Conformations via Metabolically Driven Substrate Receptor Assembly', Molecular Cell. https://doi.org/10.1016/j.molcel.2019.10.009

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abstract = "Stunning structural intricacies of the yeast GID system, now revealed more than 25 years since the discovery of glucose-induced degradation and of a protein's N terminus serving as a degron, provide a blueprint for a family of multisubunit E3s regulated through assembly with interchangeable substrate receptors induced by distinct environmental perturbations.",

author = "Shuai Qiao and Langlois, {Christine R} and Jakub Chrustowicz and Dawafuti Sherpa and Ozge Karayel and Hansen, {Fynn M} and Viola Beier and {von Gronau}, Susanne and Daniel Bollschweiler and Tillman Sch{\"a}fer and Alpi, {Arno F} and Matthias Mann and Prabu, {J Rajan} and Schulman, {Brenda A}",

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AU - Qiao, Shuai

AU - Langlois, Christine R

AU - Chrustowicz, Jakub

AU - Sherpa, Dawafuti

AU - Karayel, Ozge

AU - Hansen, Fynn M

AU - Beier, Viola

AU - von Gronau, Susanne

AU - Bollschweiler, Daniel

AU - Schäfer, Tillman

AU - Alpi, Arno F

AU - Mann, Matthias

AU - Prabu, J Rajan

AU - Schulman, Brenda A

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AB - Stunning structural intricacies of the yeast GID system, now revealed more than 25 years since the discovery of glucose-induced degradation and of a protein's N terminus serving as a degron, provide a blueprint for a family of multisubunit E3s regulated through assembly with interchangeable substrate receptors induced by distinct environmental perturbations.

U2 - 10.1016/j.molcel.2019.10.009

DO - 10.1016/j.molcel.2019.10.009

M3 - Journal article

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SN - 1097-2765

JO - Molecular Cell

JF - Molecular Cell

ER -

Interconversion between Anticipatory and Active GID E3 Ubiquitin Ligase Conformations via Metabolically Driven Substrate Receptor Assembly

Abstract

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