Interconversion between Anticipatory and Active GID E3 Ubiquitin Ligase Conformations via Metabolically Driven Substrate Receptor Assembly

Shuai Qiao; Christine R Langlois; Jakub Chrustowicz; Dawafuti Sherpa; Ozge Karayel; Fynn M Hansen; Viola Beier; Susanne von Gronau; Daniel Bollschweiler; Tillman Schäfer; Arno F Alpi; Matthias Mann; J Rajan Prabu; Brenda A Schulman

doi:10.1016/j.molcel.2019.10.009

Interconversion between Anticipatory and Active GID E3 Ubiquitin Ligase Conformations via Metabolically Driven Substrate Receptor Assembly

Shuai Qiao, Christine R Langlois, Jakub Chrustowicz, Dawafuti Sherpa, Ozge Karayel, Fynn M Hansen, Viola Beier, Susanne von Gronau, Daniel Bollschweiler, Tillman Schäfer, Arno F Alpi, Matthias Mann, J Rajan Prabu, Brenda A Schulman

12 Citationer (Scopus)

Abstract

Stunning structural intricacies of the yeast GID system, now revealed more than 25 years since the discovery of glucose-induced degradation and of a protein's N terminus serving as a degron, provide a blueprint for a family of multisubunit E3s regulated through assembly with interchangeable substrate receptors induced by distinct environmental perturbations.

Originalsprog	Engelsk
Tidsskrift	Molecular Cell
ISSN	1097-2765
DOI	https://doi.org/10.1016/j.molcel.2019.10.009
Status	Udgivet - 2 jan. 2020
Udgivet eksternt	Ja

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10.1016/j.molcel.2019.10.009

http://www.cell.com/article/S1097276519307695/pdf

Citationsformater

Qiao, S., Langlois, C. R., Chrustowicz, J., Sherpa, D., Karayel, O., Hansen, F. M., Beier, V., von Gronau, S., Bollschweiler, D., Schäfer, T., Alpi, A. F., Mann, M., Prabu, J. R., & Schulman, B. A. (2020). Interconversion between Anticipatory and Active GID E3 Ubiquitin Ligase Conformations via Metabolically Driven Substrate Receptor Assembly. Molecular Cell. https://doi.org/10.1016/j.molcel.2019.10.009

Qiao, S, Langlois, CR, Chrustowicz, J, Sherpa, D, Karayel, O, Hansen, FM, Beier, V, von Gronau, S, Bollschweiler, D, Schäfer, T, Alpi, AF, Mann, M, Prabu, JR & Schulman, BA 2020, 'Interconversion between Anticipatory and Active GID E3 Ubiquitin Ligase Conformations via Metabolically Driven Substrate Receptor Assembly', Molecular Cell. https://doi.org/10.1016/j.molcel.2019.10.009

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abstract = "Stunning structural intricacies of the yeast GID system, now revealed more than 25 years since the discovery of glucose-induced degradation and of a protein's N terminus serving as a degron, provide a blueprint for a family of multisubunit E3s regulated through assembly with interchangeable substrate receptors induced by distinct environmental perturbations.",

author = "Shuai Qiao and Langlois, {Christine R} and Jakub Chrustowicz and Dawafuti Sherpa and Ozge Karayel and Hansen, {Fynn M} and Viola Beier and {von Gronau}, Susanne and Daniel Bollschweiler and Tillman Sch{\"a}fer and Alpi, {Arno F} and Matthias Mann and Prabu, {J Rajan} and Schulman, {Brenda A}",

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doi = "10.1016/j.molcel.2019.10.009",

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T1 - Interconversion between Anticipatory and Active GID E3 Ubiquitin Ligase Conformations via Metabolically Driven Substrate Receptor Assembly

AU - Qiao, Shuai

AU - Langlois, Christine R

AU - Chrustowicz, Jakub

AU - Sherpa, Dawafuti

AU - Karayel, Ozge

AU - Hansen, Fynn M

AU - Beier, Viola

AU - von Gronau, Susanne

AU - Bollschweiler, Daniel

AU - Schäfer, Tillman

AU - Alpi, Arno F

AU - Mann, Matthias

AU - Prabu, J Rajan

AU - Schulman, Brenda A

PY - 2020/1/2

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N2 - Stunning structural intricacies of the yeast GID system, now revealed more than 25 years since the discovery of glucose-induced degradation and of a protein's N terminus serving as a degron, provide a blueprint for a family of multisubunit E3s regulated through assembly with interchangeable substrate receptors induced by distinct environmental perturbations.

AB - Stunning structural intricacies of the yeast GID system, now revealed more than 25 years since the discovery of glucose-induced degradation and of a protein's N terminus serving as a degron, provide a blueprint for a family of multisubunit E3s regulated through assembly with interchangeable substrate receptors induced by distinct environmental perturbations.

U2 - 10.1016/j.molcel.2019.10.009

DO - 10.1016/j.molcel.2019.10.009

M3 - Journal article

C2 - 31708416

SN - 1097-2765

JO - Molecular Cell

JF - Molecular Cell

ER -

Interconversion between Anticipatory and Active GID E3 Ubiquitin Ligase Conformations via Metabolically Driven Substrate Receptor Assembly

Abstract

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