Interactions between gastrointestinal nematode parasites and diarrhoea in sheep: pathogenesis and control

Andrew Richard Williams; Dieter G Palmer

doi:10.1016/j.tvjl.2011.10.009

Interactions between gastrointestinal nematode parasites and diarrhoea in sheep: pathogenesis and control

Andrew Richard Williams, Dieter G Palmer

12 Citations (Scopus)

Abstract

Diarrhoea is a major impediment to profitable sheep production in many countries as it predisposes animals to blowfly strike and contaminates wool and meat carcasses. While it is accepted that nematode parasites are a major cause of diarrhoea in grazing animals, less is known about what facets of the host-parasite relationship lead to diarrhoea and what the most appropriate control strategies are. In this review, the relationship between gastrointestinal nematode infection and diarrhoea is discussed and it is concluded that in many cases, particularly in immunologically mature sheep, diarrhoea is not due to parasite infection per se but rather due to immunopathological processes. Mechanisms that lead to faecal softening in immune sheep are considered, and the question addressed as to whether anthelmintic treatment and selective breeding of naturally parasite-resistant sheep will effectively reduce the occurrence of diarrhoea.

Original language	English
Journal	Veterinary journal (London, England : 1997)
Volume	192
Issue number	3
Pages (from-to)	279-85
Number of pages	7
DOIs	https://doi.org/10.1016/j.tvjl.2011.10.009
Publication status	Published - Jun 2012
Externally published	Yes

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10.1016/j.tvjl.2011.10.009

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title = "Interactions between gastrointestinal nematode parasites and diarrhoea in sheep: pathogenesis and control",

abstract = "Diarrhoea is a major impediment to profitable sheep production in many countries as it predisposes animals to blowfly strike and contaminates wool and meat carcasses. While it is accepted that nematode parasites are a major cause of diarrhoea in grazing animals, less is known about what facets of the host-parasite relationship lead to diarrhoea and what the most appropriate control strategies are. In this review, the relationship between gastrointestinal nematode infection and diarrhoea is discussed and it is concluded that in many cases, particularly in immunologically mature sheep, diarrhoea is not due to parasite infection per se but rather due to immunopathological processes. Mechanisms that lead to faecal softening in immune sheep are considered, and the question addressed as to whether anthelmintic treatment and selective breeding of naturally parasite-resistant sheep will effectively reduce the occurrence of diarrhoea.",

author = "Williams, {Andrew Richard} and Palmer, {Dieter G}",

year = "2012",

month = jun,

doi = "10.1016/j.tvjl.2011.10.009",

language = "English",

volume = "192",

pages = "279--85",

journal = "The Veterinary Journal",

issn = "1090-0233",

publisher = "Elsevier",

number = "3",

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T1 - Interactions between gastrointestinal nematode parasites and diarrhoea in sheep

T2 - pathogenesis and control

AU - Williams, Andrew Richard

AU - Palmer, Dieter G

PY - 2012/6

Y1 - 2012/6

N2 - Diarrhoea is a major impediment to profitable sheep production in many countries as it predisposes animals to blowfly strike and contaminates wool and meat carcasses. While it is accepted that nematode parasites are a major cause of diarrhoea in grazing animals, less is known about what facets of the host-parasite relationship lead to diarrhoea and what the most appropriate control strategies are. In this review, the relationship between gastrointestinal nematode infection and diarrhoea is discussed and it is concluded that in many cases, particularly in immunologically mature sheep, diarrhoea is not due to parasite infection per se but rather due to immunopathological processes. Mechanisms that lead to faecal softening in immune sheep are considered, and the question addressed as to whether anthelmintic treatment and selective breeding of naturally parasite-resistant sheep will effectively reduce the occurrence of diarrhoea.

AB - Diarrhoea is a major impediment to profitable sheep production in many countries as it predisposes animals to blowfly strike and contaminates wool and meat carcasses. While it is accepted that nematode parasites are a major cause of diarrhoea in grazing animals, less is known about what facets of the host-parasite relationship lead to diarrhoea and what the most appropriate control strategies are. In this review, the relationship between gastrointestinal nematode infection and diarrhoea is discussed and it is concluded that in many cases, particularly in immunologically mature sheep, diarrhoea is not due to parasite infection per se but rather due to immunopathological processes. Mechanisms that lead to faecal softening in immune sheep are considered, and the question addressed as to whether anthelmintic treatment and selective breeding of naturally parasite-resistant sheep will effectively reduce the occurrence of diarrhoea.

U2 - 10.1016/j.tvjl.2011.10.009

DO - 10.1016/j.tvjl.2011.10.009

M3 - Journal article

C2 - 22099182

SN - 1090-0233

VL - 192

SP - 279

EP - 285

JO - The Veterinary Journal

JF - The Veterinary Journal

IS - 3

ER -

Interactions between gastrointestinal nematode parasites and diarrhoea in sheep: pathogenesis and control

Abstract

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