Integration of waveguides for optical detection in microfabricated analytical devices

Jorg P. Kutter; Klaus B. Mogensen; Peter Friis; Anders M. Jorgensen; Nickolaj J. Petersen; Pieter Telleman; Jorg Hubner

Integration of waveguides for optical detection in microfabricated analytical devices

Jorg P. Kutter^*, Klaus B. Mogensen, Peter Friis, Anders M. Jorgensen, Nickolaj J. Petersen, Pieter Telleman, Jorg Hubner

^*Corresponding author for this work

5 Citations (Scopus)

Abstract

Buried optical channel waveguides integrated with a fluidic channel network on a planar microdevice are presented. The waveguides were fabricated using silica-on-silicon technology with the goal to replace bulk optical elements and facilitate various optical detection techniques for miniaturized total analysis systems or lab-on-a-chip systems. Waveguide structures with core layers doped with germanium were employed for fluorescence measurements, while waveguides with nitrogen-only doped core layers were used for absorbance measurements. By the elimination of germanium oxygen deficiency centers transmission of light down to 210 nm was possible, allowing absorbance measurements in the mid and far UV region (210 to 280 nm), which is the region where a large number of different molecules absorb light. Robust, alignment-free microdevices, which can easily be hooked up to a number of light sources and detectors, were used for fluorescence measurements of two dyes, fluorescein and Bodipy, and absorbance measurements of a stress-reducing drug, propranolol. The lowest detected concentrations were 250 pM for fluorescein, 100 nM for Bodipy and 12 μM for propranolol.

Original language	English
Journal	Proceedings of SPIE - The International Society for Optical Engineering
Volume	4177
Pages (from-to)	98-105
Number of pages	8
ISSN	0277-786X
Publication status	Published - 1 Dec 2000
Event	Microfluidic Devices and Systems III - Santa Clara, CA, USA Duration: 18 Sept 2000 → 19 Sept 2000

Conference

Conference	Microfluidic Devices and Systems III
City	Santa Clara, CA, USA
Period	18/09/2000 → 19/09/2000
Sponsor	SPIE-The Internatinal Society for Optical Engineering

Cite this

@inproceedings{bfd109fc94904066b28e5b9d4043ca6a,

title = "Integration of waveguides for optical detection in microfabricated analytical devices",

abstract = "Buried optical channel waveguides integrated with a fluidic channel network on a planar microdevice are presented. The waveguides were fabricated using silica-on-silicon technology with the goal to replace bulk optical elements and facilitate various optical detection techniques for miniaturized total analysis systems or lab-on-a-chip systems. Waveguide structures with core layers doped with germanium were employed for fluorescence measurements, while waveguides with nitrogen-only doped core layers were used for absorbance measurements. By the elimination of germanium oxygen deficiency centers transmission of light down to 210 nm was possible, allowing absorbance measurements in the mid and far UV region (210 to 280 nm), which is the region where a large number of different molecules absorb light. Robust, alignment-free microdevices, which can easily be hooked up to a number of light sources and detectors, were used for fluorescence measurements of two dyes, fluorescein and Bodipy, and absorbance measurements of a stress-reducing drug, propranolol. The lowest detected concentrations were 250 pM for fluorescein, 100 nM for Bodipy and 12 μM for propranolol.",

author = "Kutter, {Jorg P.} and Mogensen, {Klaus B.} and Peter Friis and Jorgensen, {Anders M.} and Petersen, {Nickolaj J.} and Pieter Telleman and Jorg Hubner",

year = "2000",

month = dec,

day = "1",

language = "English",

volume = "4177",

pages = "98--105",

journal = "Progress in Biomedical Optics and Imaging",

issn = "1605-7422",

publisher = "S P I E - International Society for Optical Engineering",

note = "Microfluidic Devices and Systems III ; Conference date: 18-09-2000 Through 19-09-2000",

}

TY - GEN

T1 - Integration of waveguides for optical detection in microfabricated analytical devices

AU - Kutter, Jorg P.

AU - Mogensen, Klaus B.

AU - Friis, Peter

AU - Jorgensen, Anders M.

AU - Petersen, Nickolaj J.

AU - Telleman, Pieter

AU - Hubner, Jorg

PY - 2000/12/1

Y1 - 2000/12/1

N2 - Buried optical channel waveguides integrated with a fluidic channel network on a planar microdevice are presented. The waveguides were fabricated using silica-on-silicon technology with the goal to replace bulk optical elements and facilitate various optical detection techniques for miniaturized total analysis systems or lab-on-a-chip systems. Waveguide structures with core layers doped with germanium were employed for fluorescence measurements, while waveguides with nitrogen-only doped core layers were used for absorbance measurements. By the elimination of germanium oxygen deficiency centers transmission of light down to 210 nm was possible, allowing absorbance measurements in the mid and far UV region (210 to 280 nm), which is the region where a large number of different molecules absorb light. Robust, alignment-free microdevices, which can easily be hooked up to a number of light sources and detectors, were used for fluorescence measurements of two dyes, fluorescein and Bodipy, and absorbance measurements of a stress-reducing drug, propranolol. The lowest detected concentrations were 250 pM for fluorescein, 100 nM for Bodipy and 12 μM for propranolol.

AB - Buried optical channel waveguides integrated with a fluidic channel network on a planar microdevice are presented. The waveguides were fabricated using silica-on-silicon technology with the goal to replace bulk optical elements and facilitate various optical detection techniques for miniaturized total analysis systems or lab-on-a-chip systems. Waveguide structures with core layers doped with germanium were employed for fluorescence measurements, while waveguides with nitrogen-only doped core layers were used for absorbance measurements. By the elimination of germanium oxygen deficiency centers transmission of light down to 210 nm was possible, allowing absorbance measurements in the mid and far UV region (210 to 280 nm), which is the region where a large number of different molecules absorb light. Robust, alignment-free microdevices, which can easily be hooked up to a number of light sources and detectors, were used for fluorescence measurements of two dyes, fluorescein and Bodipy, and absorbance measurements of a stress-reducing drug, propranolol. The lowest detected concentrations were 250 pM for fluorescein, 100 nM for Bodipy and 12 μM for propranolol.

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M3 - Conference article

AN - SCOPUS:0034547211

SN - 1605-7422

VL - 4177

SP - 98

EP - 105

JO - Progress in Biomedical Optics and Imaging

JF - Progress in Biomedical Optics and Imaging

T2 - Microfluidic Devices and Systems III

Y2 - 18 September 2000 through 19 September 2000

ER -

Integration of waveguides for optical detection in microfabricated analytical devices

Abstract

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