Insights into the key roles of proteoglycans in breast cancer biology and translational medicine

Achilleas D. Theocharis; Spyros S. Skandalis; Thomas Neill; Hinke A. B. Multhaupt; Mario Hubo; Helena Frey; Sandeep Gopal; Angelica  Gomes; Nikos Afratis; Hooi Ching Lim; John R. Couchman; Jorge Filmus; Ralph D. Sanderson; Liliana Schaefer; Renato V. Iozzo; Nikos K. Karamanos

doi:10.1016/j.bbcan.2015.03.006

Insights into the key roles of proteoglycans in breast cancer biology and translational medicine

Achilleas D. Theocharis, Spyros S. Skandalis, Thomas Neill, Hinke A. B. Multhaupt, Mario Hubo, Helena Frey, Sandeep Gopal, Angelica Gomes, Nikos Afratis, Hooi Ching Lim, John R. Couchman, Jorge Filmus, Ralph D. Sanderson, Liliana Schaefer, Renato V. Iozzo, Nikos K. Karamanos

Nutritional Immunology

109 Citations (Scopus)

Abstract

Proteoglycans control numerous normal and pathological processes, among which are morphogenesis, tissue repair, inflammation, vascularization and cancer metastasis. During tumor development and growth, proteoglycan expression is markedly modified in the tumor microenvironment. Altered expression of proteoglycans on tumor and stromal cell membranes affects cancer cell signaling, growth and survival, cell adhesion, migration and angiogenesis. Despite the high complexity and heterogeneity of breast cancer, the rapid evolution in our knowledge that proteoglycans are among the key players in the breast tumor microenvironment suggests their potential as pharmacological targets in this type of cancer. It has been recently suggested that pharmacological treatment may target proteoglycan metabolism, their utilization as targets for immunotherapy or their direct use as therapeutic agents. The diversity inherent in the proteoglycans that will be presented herein provides the potential for multiple layers of regulation of breast tumor behavior. This review summarizes recent developments concerning the biology of selected proteoglycans in breast cancer, and presents potential targeted therapeutic approaches based on their novel key roles in breast cancer.

Original language	English
Journal	BBA Reviews on Cancer
Volume	1855
Issue number	2
Pages (from-to)	276–300
Number of pages	25
ISSN	0304-419X
DOIs	https://doi.org/10.1016/j.bbcan.2015.03.006
Publication status	Published - 1 Apr 2015

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Theocharis, A. D., Skandalis, S. S., Neill, T., Multhaupt, H. A. B., Hubo, M., Frey, H., Gopal, S., Gomes, A., Afratis, N., Lim, H. C., Couchman, J. R., Filmus, J., Sanderson, R. D., Schaefer, L., Iozzo, R. V., & Karamanos, N. K. (2015). Insights into the key roles of proteoglycans in breast cancer biology and translational medicine. BBA Reviews on Cancer, 1855(2), 276–300. https://doi.org/10.1016/j.bbcan.2015.03.006

Theocharis, AD, Skandalis, SS, Neill, T, Multhaupt, HAB, Hubo, M, Frey, H, Gopal, S, Gomes, A, Afratis, N, Lim, HC, Couchman, JR, Filmus, J, Sanderson, RD, Schaefer, L, Iozzo, RV & Karamanos, NK 2015, 'Insights into the key roles of proteoglycans in breast cancer biology and translational medicine', BBA Reviews on Cancer, vol. 1855, no. 2, pp. 276–300. https://doi.org/10.1016/j.bbcan.2015.03.006

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title = "Insights into the key roles of proteoglycans in breast cancer biology and translational medicine",

abstract = "Proteoglycans control numerous normal and pathological processes, among which are morphogenesis, tissue repair, inflammation, vascularization and cancer metastasis. During tumor development and growth, proteoglycan expression is markedly modified in the tumor microenvironment. Altered expression of proteoglycans on tumor and stromal cell membranes affects cancer cell signaling, growth and survival, cell adhesion, migration and angiogenesis. Despite the high complexity and heterogeneity of breast cancer, the rapid evolution in our knowledge that proteoglycans are among the key players in the breast tumor microenvironment suggests their potential as pharmacological targets in this type of cancer. It has been recently suggested that pharmacological treatment may target proteoglycan metabolism, their utilization as targets for immunotherapy or their direct use as therapeutic agents. The diversity inherent in the proteoglycans that will be presented herein provides the potential for multiple layers of regulation of breast tumor behavior. This review summarizes recent developments concerning the biology of selected proteoglycans in breast cancer, and presents potential targeted therapeutic approaches based on their novel key roles in breast cancer.",

author = "Theocharis, {Achilleas D.} and Skandalis, {Spyros S.} and Thomas Neill and Multhaupt, {Hinke A. B.} and Mario Hubo and Helena Frey and Sandeep Gopal and Angelica Gomes and Nikos Afratis and Lim, {Hooi Ching} and Couchman, {John R.} and Jorge Filmus and Sanderson, {Ralph D.} and Liliana Schaefer and Iozzo, {Renato V.} and Karamanos, {Nikos K.}",

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AU - Theocharis, Achilleas D.

AU - Skandalis, Spyros S.

AU - Neill, Thomas

AU - Multhaupt, Hinke A. B.

AU - Hubo, Mario

AU - Frey, Helena

AU - Gopal, Sandeep

AU - Gomes, Angelica

AU - Afratis, Nikos

AU - Lim, Hooi Ching

AU - Couchman, John R.

AU - Filmus, Jorge

AU - Sanderson, Ralph D.

AU - Schaefer, Liliana

AU - Iozzo, Renato V.

AU - Karamanos, Nikos K.

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AB - Proteoglycans control numerous normal and pathological processes, among which are morphogenesis, tissue repair, inflammation, vascularization and cancer metastasis. During tumor development and growth, proteoglycan expression is markedly modified in the tumor microenvironment. Altered expression of proteoglycans on tumor and stromal cell membranes affects cancer cell signaling, growth and survival, cell adhesion, migration and angiogenesis. Despite the high complexity and heterogeneity of breast cancer, the rapid evolution in our knowledge that proteoglycans are among the key players in the breast tumor microenvironment suggests their potential as pharmacological targets in this type of cancer. It has been recently suggested that pharmacological treatment may target proteoglycan metabolism, their utilization as targets for immunotherapy or their direct use as therapeutic agents. The diversity inherent in the proteoglycans that will be presented herein provides the potential for multiple layers of regulation of breast tumor behavior. This review summarizes recent developments concerning the biology of selected proteoglycans in breast cancer, and presents potential targeted therapeutic approaches based on their novel key roles in breast cancer.

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DO - 10.1016/j.bbcan.2015.03.006

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EP - 300

JO - BBA Reviews on Cancer

JF - BBA Reviews on Cancer

IS - 2

ER -

Insights into the key roles of proteoglycans in breast cancer biology and translational medicine

Abstract

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