TY - JOUR
T1 - Insights into the key roles of proteoglycans in breast cancer biology and translational medicine
AU - Theocharis, Achilleas D.
AU - Skandalis, Spyros S.
AU - Neill, Thomas
AU - Multhaupt, Hinke A. B.
AU - Hubo, Mario
AU - Frey, Helena
AU - Gopal, Sandeep
AU - Gomes, Angelica
AU - Afratis, Nikos
AU - Lim, Hooi Ching
AU - Couchman, John R.
AU - Filmus, Jorge
AU - Sanderson, Ralph D.
AU - Schaefer, Liliana
AU - Iozzo, Renato V.
AU - Karamanos, Nikos K.
N1 - Copyright © 2015. Published by Elsevier B.V.
PY - 2015/4/1
Y1 - 2015/4/1
N2 - Proteoglycans control numerous normal and pathological processes, among which are morphogenesis, tissue repair, inflammation, vascularization and cancer metastasis. During tumor development and growth, proteoglycan expression is markedly modified in the tumor microenvironment. Altered expression of proteoglycans on tumor and stromal cell membranes affects cancer cell signaling, growth and survival, cell adhesion, migration and angiogenesis. Despite the high complexity and heterogeneity of breast cancer, the rapid evolution in our knowledge that proteoglycans are among the key players in the breast tumor microenvironment suggests their potential as pharmacological targets in this type of cancer. It has been recently suggested that pharmacological treatment may target proteoglycan metabolism, their utilization as targets for immunotherapy or their direct use as therapeutic agents. The diversity inherent in the proteoglycans that will be presented herein provides the potential for multiple layers of regulation of breast tumor behavior. This review summarizes recent developments concerning the biology of selected proteoglycans in breast cancer, and presents potential targeted therapeutic approaches based on their novel key roles in breast cancer.
AB - Proteoglycans control numerous normal and pathological processes, among which are morphogenesis, tissue repair, inflammation, vascularization and cancer metastasis. During tumor development and growth, proteoglycan expression is markedly modified in the tumor microenvironment. Altered expression of proteoglycans on tumor and stromal cell membranes affects cancer cell signaling, growth and survival, cell adhesion, migration and angiogenesis. Despite the high complexity and heterogeneity of breast cancer, the rapid evolution in our knowledge that proteoglycans are among the key players in the breast tumor microenvironment suggests their potential as pharmacological targets in this type of cancer. It has been recently suggested that pharmacological treatment may target proteoglycan metabolism, their utilization as targets for immunotherapy or their direct use as therapeutic agents. The diversity inherent in the proteoglycans that will be presented herein provides the potential for multiple layers of regulation of breast tumor behavior. This review summarizes recent developments concerning the biology of selected proteoglycans in breast cancer, and presents potential targeted therapeutic approaches based on their novel key roles in breast cancer.
U2 - 10.1016/j.bbcan.2015.03.006
DO - 10.1016/j.bbcan.2015.03.006
M3 - Review
C2 - 25829250
SN - 0304-419X
VL - 1855
SP - 276
EP - 300
JO - Biochimica et Biophysica Acta - Reviews on Cancer
JF - Biochimica et Biophysica Acta - Reviews on Cancer
IS - 2
ER -
