Insights into the Genetic Susceptibility to Type 2 Diabetes from Genome-Wide Association Studies of Obesity-Related Traits

Tugce Karaderi; Alexander W. Drong; Cecilia M. Lindgren

doi:10.1007/s11892-015-0648-8

Insights into the Genetic Susceptibility to Type 2 Diabetes from Genome-Wide Association Studies of Obesity-Related Traits

Tugce Karaderi, Alexander W. Drong, Cecilia M. Lindgren^*

^*Corresponding author for this work

38 Citations (Scopus)

Abstract

Obesity and type 2 diabetes (T2D) are common and complex metabolic diseases, which are caused by an interchange between environmental and genetic factors. Recently, a number of large-scale genome-wide association studies (GWAS) have improved our knowledge of the genetic architecture and biological mechanisms of these diseases. Currently, more than ~250 genetic loci have been found for monogenic, syndromic, or common forms of T2D and/or obesity-related traits. In this review, we discuss the implications of these GWAS for obesity and T2D, and investigate the overlap of loci for obesity-related traits and T2D, highlighting potential mechanisms that affect T2D susceptibility.

Original language	English
Article number	83
Journal	Current Diabetes Reports
Volume	15
Issue number	10
ISSN	1534-4827
DOIs	https://doi.org/10.1007/s11892-015-0648-8
Publication status	Published - 22 Oct 2015
Externally published	Yes

Keywords

Adiponectin
Beta-cell function
Body mass index
Fat distribution
Fat percent
Genome-wide association study
Insulin resistance
Leptin
Non-alcoholic fatty liver disease
Obesity
Pericardial fat
Sexual dimorphism
Subcutaneous fat
Type 2 diabetes
Visceral fat
Waist-to-hip ratio

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s11892-015-0648-8

Cite this

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title = "Insights into the Genetic Susceptibility to Type 2 Diabetes from Genome-Wide Association Studies of Obesity-Related Traits",

abstract = "Obesity and type 2 diabetes (T2D) are common and complex metabolic diseases, which are caused by an interchange between environmental and genetic factors. Recently, a number of large-scale genome-wide association studies (GWAS) have improved our knowledge of the genetic architecture and biological mechanisms of these diseases. Currently, more than ~250 genetic loci have been found for monogenic, syndromic, or common forms of T2D and/or obesity-related traits. In this review, we discuss the implications of these GWAS for obesity and T2D, and investigate the overlap of loci for obesity-related traits and T2D, highlighting potential mechanisms that affect T2D susceptibility.",

keywords = "Adiponectin, Beta-cell function, Body mass index, Fat distribution, Fat percent, Genome-wide association study, Insulin resistance, Leptin, Non-alcoholic fatty liver disease, Obesity, Pericardial fat, Sexual dimorphism, Subcutaneous fat, Type 2 diabetes, Visceral fat, Waist-to-hip ratio",

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AU - Lindgren, Cecilia M.

PY - 2015/10/22

Y1 - 2015/10/22

N2 - Obesity and type 2 diabetes (T2D) are common and complex metabolic diseases, which are caused by an interchange between environmental and genetic factors. Recently, a number of large-scale genome-wide association studies (GWAS) have improved our knowledge of the genetic architecture and biological mechanisms of these diseases. Currently, more than ~250 genetic loci have been found for monogenic, syndromic, or common forms of T2D and/or obesity-related traits. In this review, we discuss the implications of these GWAS for obesity and T2D, and investigate the overlap of loci for obesity-related traits and T2D, highlighting potential mechanisms that affect T2D susceptibility.

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KW - Adiponectin

KW - Beta-cell function

KW - Body mass index

KW - Fat distribution

KW - Fat percent

KW - Genome-wide association study

KW - Insulin resistance

KW - Leptin

KW - Non-alcoholic fatty liver disease

KW - Obesity

KW - Pericardial fat

KW - Sexual dimorphism

KW - Subcutaneous fat

KW - Type 2 diabetes

KW - Visceral fat

KW - Waist-to-hip ratio

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Insights into the Genetic Susceptibility to Type 2 Diabetes from Genome-Wide Association Studies of Obesity-Related Traits

Abstract

Keywords

UN SDGs

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