Insights into the Genetic Susceptibility to Type 2 Diabetes from Genome-Wide Association Studies of Obesity-Related Traits

TY - JOUR

T1 - Insights into the Genetic Susceptibility to Type 2 Diabetes from Genome-Wide Association Studies of Obesity-Related Traits

AU - Karaderi, Tugce

AU - Drong, Alexander W.

AU - Lindgren, Cecilia M.

PY - 2015/10/22

Y1 - 2015/10/22

N2 - Obesity and type 2 diabetes (T2D) are common and complex metabolic diseases, which are caused by an interchange between environmental and genetic factors. Recently, a number of large-scale genome-wide association studies (GWAS) have improved our knowledge of the genetic architecture and biological mechanisms of these diseases. Currently, more than ~250 genetic loci have been found for monogenic, syndromic, or common forms of T2D and/or obesity-related traits. In this review, we discuss the implications of these GWAS for obesity and T2D, and investigate the overlap of loci for obesity-related traits and T2D, highlighting potential mechanisms that affect T2D susceptibility.

AB - Obesity and type 2 diabetes (T2D) are common and complex metabolic diseases, which are caused by an interchange between environmental and genetic factors. Recently, a number of large-scale genome-wide association studies (GWAS) have improved our knowledge of the genetic architecture and biological mechanisms of these diseases. Currently, more than ~250 genetic loci have been found for monogenic, syndromic, or common forms of T2D and/or obesity-related traits. In this review, we discuss the implications of these GWAS for obesity and T2D, and investigate the overlap of loci for obesity-related traits and T2D, highlighting potential mechanisms that affect T2D susceptibility.

KW - Adiponectin

KW - Beta-cell function

KW - Body mass index

KW - Fat distribution

KW - Fat percent

KW - Genome-wide association study

KW - Insulin resistance

KW - Leptin

KW - Non-alcoholic fatty liver disease

KW - Obesity

KW - Pericardial fat

KW - Sexual dimorphism

KW - Subcutaneous fat

KW - Type 2 diabetes

KW - Visceral fat

KW - Waist-to-hip ratio

UR - http://www.scopus.com/inward/record.url?scp=84941915615&partnerID=8YFLogxK

U2 - 10.1007/s11892-015-0648-8

DO - 10.1007/s11892-015-0648-8

M3 - Review

C2 - 26363598

AN - SCOPUS:84941915615

SN - 1534-4827

VL - 15

JO - Current Diabetes Reports

JF - Current Diabetes Reports

IS - 10

M1 - 83

ER -