Initial experience with EUS-guided microbiopsy forceps in diagnosing pancreatic cystic lesions: A multicenter feasibility study (with video)

Bojan Kovacevic; John Gásdal Karstensen; Roald Flesland Havre; Khanh Do Cong Pham; Marc Giovannini; Emanuele Dabizzi; Paolo Arcidiacono; Erwin Santo; Enrique Vazquez Sequeiros; Pia Klausen; Charlotte Vestrup Rift; Jane Preuss Hasselby; Anders Toxværd; Evangelos Kalaitzakis; Carsten Palnæs Hansen; Peter Vilmann

doi:10.4103/eus.eus_16_18

Initial experience with EUS-guided microbiopsy forceps in diagnosing pancreatic cystic lesions: A multicenter feasibility study (with video)

Bojan Kovacevic^*, John Gásdal Karstensen, Roald Flesland Havre, Khanh Do Cong Pham, Marc Giovannini, Emanuele Dabizzi, Paolo Arcidiacono, Erwin Santo, Enrique Vazquez Sequeiros, Pia Klausen, Charlotte Vestrup Rift, Jane Preuss Hasselby, Anders Toxværd, Evangelos Kalaitzakis, Carsten Palnæs Hansen, Peter Vilmann

^*Corresponding author for this work

Department of Clinical Medicine

17 Citations (Scopus)

Abstract

Background and Objectives: Cystic lesions of the pancreas represent a diagnostic dilemma. Recently, a through-the-needle microbiopsy forceps has become available, enabling procurement of EUS-guided histological specimens from the pancreatic cyst wall. The aim of this study was to evaluate the use of this novel instrument in a multicenter clinical setting. Patients and Methods: Patients referred for EUS evaluation of pancreatic cysts and attempted EUS-guided microbiopsy was included retrospectively from six international tertiary centers. Patient’s demographics, EUS findings, technical and clinical success, and histopathological results were recorded. Results: A total of 28 patients were identified. We report a technical success rate of 85.7% (n = 24). Biopsies were generally of good quality and contributed to the diagnosis in 20 patients (clinical success of 71.4%). Three adverse events were recorded (10.7%). Conclusions: The use of the microbiopsy forceps is feasible with acceptable rates of technical and clinical success. Prospective studies are warranted to determine the diagnostic potential compared to the other modalities. However, the results from this preliminary study are promising.

Original language	English
Journal	Endoscopic Ultrasound
Volume	7
Issue number	6
Pages (from-to)	383-388
Number of pages	6
ISSN	2303-9027
DOIs	https://doi.org/10.4103/eus.eus_16_18
Publication status	Published - 2018

Keywords

EUS-FNA
IPMN
Microbiopsy forceps
Moray
Pancreatic cancer
Pancreatic cysts

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.4103/eus.eus_16_18

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Kovacevic, B., Karstensen, J. G., Havre, R. F., Pham, K. D. C., Giovannini, M., Dabizzi, E., Arcidiacono, P., Santo, E., Sequeiros, E. V., Klausen, P., Rift, C. V., Hasselby, J. P., Toxværd, A., Kalaitzakis, E., Hansen, C. P., & Vilmann, P. (2018). Initial experience with EUS-guided microbiopsy forceps in diagnosing pancreatic cystic lesions: A multicenter feasibility study (with video). Endoscopic Ultrasound, 7(6), 383-388. https://doi.org/10.4103/eus.eus_16_18

Kovacevic, B, Karstensen, JG, Havre, RF, Pham, KDC, Giovannini, M, Dabizzi, E, Arcidiacono, P, Santo, E, Sequeiros, EV, Klausen, P, Rift, CV , Hasselby, JP, Toxværd, A, Kalaitzakis, E, Hansen, CP & Vilmann, P 2018, 'Initial experience with EUS-guided microbiopsy forceps in diagnosing pancreatic cystic lesions: A multicenter feasibility study (with video)', Endoscopic Ultrasound, vol. 7, no. 6, pp. 383-388. https://doi.org/10.4103/eus.eus_16_18

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abstract = "Background and Objectives: Cystic lesions of the pancreas represent a diagnostic dilemma. Recently, a through-the-needle microbiopsy forceps has become available, enabling procurement of EUS-guided histological specimens from the pancreatic cyst wall. The aim of this study was to evaluate the use of this novel instrument in a multicenter clinical setting. Patients and Methods: Patients referred for EUS evaluation of pancreatic cysts and attempted EUS-guided microbiopsy was included retrospectively from six international tertiary centers. Patient{\textquoteright}s demographics, EUS findings, technical and clinical success, and histopathological results were recorded. Results: A total of 28 patients were identified. We report a technical success rate of 85.7% (n = 24). Biopsies were generally of good quality and contributed to the diagnosis in 20 patients (clinical success of 71.4%). Three adverse events were recorded (10.7%). Conclusions: The use of the microbiopsy forceps is feasible with acceptable rates of technical and clinical success. Prospective studies are warranted to determine the diagnostic potential compared to the other modalities. However, the results from this preliminary study are promising.",

keywords = "EUS-FNA, IPMN, Microbiopsy forceps, Moray, Pancreatic cancer, Pancreatic cysts",

author = "Bojan Kovacevic and Karstensen, {John G{\'a}sdal} and Havre, {Roald Flesland} and Pham, {Khanh Do Cong} and Marc Giovannini and Emanuele Dabizzi and Paolo Arcidiacono and Erwin Santo and Sequeiros, {Enrique Vazquez} and Pia Klausen and Rift, {Charlotte Vestrup} and Hasselby, {Jane Preuss} and Anders Toxv{\ae}rd and Evangelos Kalaitzakis and Hansen, {Carsten Paln{\ae}s} and Peter Vilmann",

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doi = "10.4103/eus.eus_16_18",

language = "English",

volume = "7",

pages = "383--388",

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T1 - Initial experience with EUS-guided microbiopsy forceps in diagnosing pancreatic cystic lesions

T2 - A multicenter feasibility study (with video)

AU - Kovacevic, Bojan

AU - Karstensen, John Gásdal

AU - Havre, Roald Flesland

AU - Pham, Khanh Do Cong

AU - Giovannini, Marc

AU - Dabizzi, Emanuele

AU - Arcidiacono, Paolo

AU - Santo, Erwin

AU - Sequeiros, Enrique Vazquez

AU - Klausen, Pia

AU - Rift, Charlotte Vestrup

AU - Hasselby, Jane Preuss

AU - Toxværd, Anders

AU - Kalaitzakis, Evangelos

AU - Hansen, Carsten Palnæs

AU - Vilmann, Peter

PY - 2018

Y1 - 2018

N2 - Background and Objectives: Cystic lesions of the pancreas represent a diagnostic dilemma. Recently, a through-the-needle microbiopsy forceps has become available, enabling procurement of EUS-guided histological specimens from the pancreatic cyst wall. The aim of this study was to evaluate the use of this novel instrument in a multicenter clinical setting. Patients and Methods: Patients referred for EUS evaluation of pancreatic cysts and attempted EUS-guided microbiopsy was included retrospectively from six international tertiary centers. Patient’s demographics, EUS findings, technical and clinical success, and histopathological results were recorded. Results: A total of 28 patients were identified. We report a technical success rate of 85.7% (n = 24). Biopsies were generally of good quality and contributed to the diagnosis in 20 patients (clinical success of 71.4%). Three adverse events were recorded (10.7%). Conclusions: The use of the microbiopsy forceps is feasible with acceptable rates of technical and clinical success. Prospective studies are warranted to determine the diagnostic potential compared to the other modalities. However, the results from this preliminary study are promising.

AB - Background and Objectives: Cystic lesions of the pancreas represent a diagnostic dilemma. Recently, a through-the-needle microbiopsy forceps has become available, enabling procurement of EUS-guided histological specimens from the pancreatic cyst wall. The aim of this study was to evaluate the use of this novel instrument in a multicenter clinical setting. Patients and Methods: Patients referred for EUS evaluation of pancreatic cysts and attempted EUS-guided microbiopsy was included retrospectively from six international tertiary centers. Patient’s demographics, EUS findings, technical and clinical success, and histopathological results were recorded. Results: A total of 28 patients were identified. We report a technical success rate of 85.7% (n = 24). Biopsies were generally of good quality and contributed to the diagnosis in 20 patients (clinical success of 71.4%). Three adverse events were recorded (10.7%). Conclusions: The use of the microbiopsy forceps is feasible with acceptable rates of technical and clinical success. Prospective studies are warranted to determine the diagnostic potential compared to the other modalities. However, the results from this preliminary study are promising.

KW - EUS-FNA

KW - IPMN

KW - Microbiopsy forceps

KW - Moray

KW - Pancreatic cancer

KW - Pancreatic cysts

U2 - 10.4103/eus.eus_16_18

DO - 10.4103/eus.eus_16_18

M3 - Journal article

C2 - 30168479

AN - SCOPUS:85057625812

SN - 2303-9027

VL - 7

SP - 383

EP - 388

JO - Endoscopic Ultrasound

JF - Endoscopic Ultrasound

IS - 6

ER -

Initial experience with EUS-guided microbiopsy forceps in diagnosing pancreatic cystic lesions: A multicenter feasibility study (with video)

Abstract

Keywords

UN SDGs

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