Inhibited insulin signaling in mouse hepatocytes is associated with increased phosphatidic acid but not diacylglycerol

Chongben Zhang; Gwen Hwarng; Daniel E Cooper; Trisha Jean Grevengoed; James M Eaton; Viswanathan Natarajan; Thurl E Harris; Rosalind A Coleman

doi:10.1074/jbc.M114.602789

Inhibited insulin signaling in mouse hepatocytes is associated with increased phosphatidic acid but not diacylglycerol

Chongben Zhang, Gwen Hwarng, Daniel E Cooper, Trisha Jean Grevengoed, James M Eaton, Viswanathan Natarajan, Thurl E Harris, Rosalind A Coleman

19 Citations (Scopus)

Abstract

Background: Ahe mechanism underlying the association of triacylglycerol storage and insulin resistance is unclear. Results: Increasing phosphatidic acid (PA) in primary hepatocytes via de novo synthesis or action of phospholipase D or diacylglycerol kinase-θ disrupts insulin signaling. Conclusion: PA derived from different sources inhibits insulin signaling. Significance: Increases in hepatocyte PA may mechanistically link lipid storage and insulin action.

Original language	English
Journal	The Journal of Biological Chemistry
Volume	290
Issue number	6
Pages (from-to)	3519-28
Number of pages	10
ISSN	0021-9258
DOIs	https://doi.org/10.1074/jbc.M114.602789
Publication status	Published - 6 Feb 2015
Externally published	Yes

Keywords

Animals
Carrier Proteins
Cells, Cultured
Diacylglycerol Kinase
Diglycerides
Glycerol-3-Phosphate O-Acyltransferase
Hepatocytes
Insulin
Mice
Mice, Inbred C57BL
Phosphatidic Acids
Phospholipase D
Protein Kinase C
Signal Transduction
TOR Serine-Threonine Kinases

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10.1074/jbc.M114.602789

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title = "Inhibited insulin signaling in mouse hepatocytes is associated with increased phosphatidic acid but not diacylglycerol",

abstract = "Background: Ahe mechanism underlying the association of triacylglycerol storage and insulin resistance is unclear. Results: Increasing phosphatidic acid (PA) in primary hepatocytes via de novo synthesis or action of phospholipase D or diacylglycerol kinase-θ disrupts insulin signaling. Conclusion: PA derived from different sources inhibits insulin signaling. Significance: Increases in hepatocyte PA may mechanistically link lipid storage and insulin action.",

keywords = "Animals, Carrier Proteins, Cells, Cultured, Diacylglycerol Kinase, Diglycerides, Glycerol-3-Phosphate O-Acyltransferase, Hepatocytes, Insulin, Mice, Mice, Inbred C57BL, Phosphatidic Acids, Phospholipase D, Protein Kinase C, Signal Transduction, TOR Serine-Threonine Kinases",

author = "Chongben Zhang and Gwen Hwarng and Cooper, {Daniel E} and Grevengoed, {Trisha Jean} and Eaton, {James M} and Viswanathan Natarajan and Harris, {Thurl E} and Coleman, {Rosalind A}",

note = "{\textcopyright} 2015 by The American Society for Biochemistry and Molecular Biology, Inc.",

year = "2015",

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doi = "10.1074/jbc.M114.602789",

language = "English",

volume = "290",

pages = "3519--28",

journal = "Journal of Biological Chemistry",

issn = "0021-9258",

publisher = "American Society for Biochemistry and Molecular Biology, Inc.",

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T1 - Inhibited insulin signaling in mouse hepatocytes is associated with increased phosphatidic acid but not diacylglycerol

AU - Zhang, Chongben

AU - Hwarng, Gwen

AU - Cooper, Daniel E

AU - Grevengoed, Trisha Jean

AU - Eaton, James M

AU - Natarajan, Viswanathan

AU - Harris, Thurl E

AU - Coleman, Rosalind A

PY - 2015/2/6

Y1 - 2015/2/6

N2 - Background: Ahe mechanism underlying the association of triacylglycerol storage and insulin resistance is unclear. Results: Increasing phosphatidic acid (PA) in primary hepatocytes via de novo synthesis or action of phospholipase D or diacylglycerol kinase-θ disrupts insulin signaling. Conclusion: PA derived from different sources inhibits insulin signaling. Significance: Increases in hepatocyte PA may mechanistically link lipid storage and insulin action.

AB - Background: Ahe mechanism underlying the association of triacylglycerol storage and insulin resistance is unclear. Results: Increasing phosphatidic acid (PA) in primary hepatocytes via de novo synthesis or action of phospholipase D or diacylglycerol kinase-θ disrupts insulin signaling. Conclusion: PA derived from different sources inhibits insulin signaling. Significance: Increases in hepatocyte PA may mechanistically link lipid storage and insulin action.

KW - Animals

KW - Carrier Proteins

KW - Cells, Cultured

KW - Diacylglycerol Kinase

KW - Diglycerides

KW - Glycerol-3-Phosphate O-Acyltransferase

KW - Hepatocytes

KW - Insulin

KW - Mice

KW - Mice, Inbred C57BL

KW - Phosphatidic Acids

KW - Phospholipase D

KW - Protein Kinase C

KW - Signal Transduction

KW - TOR Serine-Threonine Kinases

U2 - 10.1074/jbc.M114.602789

DO - 10.1074/jbc.M114.602789

M3 - Journal article

C2 - 25512376

SN - 0021-9258

VL - 290

SP - 3519

EP - 3528

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 6

ER -

Inhibited insulin signaling in mouse hepatocytes is associated with increased phosphatidic acid but not diacylglycerol

Abstract

Keywords

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