@article{9645aa08a23b43b39902447cb7570e62,
title = "Inhibited insulin signaling in mouse hepatocytes is associated with increased phosphatidic acid but not diacylglycerol",
abstract = "Background: Ahe mechanism underlying the association of triacylglycerol storage and insulin resistance is unclear. Results: Increasing phosphatidic acid (PA) in primary hepatocytes via de novo synthesis or action of phospholipase D or diacylglycerol kinase-θ disrupts insulin signaling. Conclusion: PA derived from different sources inhibits insulin signaling. Significance: Increases in hepatocyte PA may mechanistically link lipid storage and insulin action.",
keywords = "Animals, Carrier Proteins, Cells, Cultured, Diacylglycerol Kinase, Diglycerides, Glycerol-3-Phosphate O-Acyltransferase, Hepatocytes, Insulin, Mice, Mice, Inbred C57BL, Phosphatidic Acids, Phospholipase D, Protein Kinase C, Signal Transduction, TOR Serine-Threonine Kinases",
author = "Chongben Zhang and Gwen Hwarng and Cooper, {Daniel E} and Grevengoed, {Trisha Jean} and Eaton, {James M} and Viswanathan Natarajan and Harris, {Thurl E} and Coleman, {Rosalind A}",
note = "{\textcopyright} 2015 by The American Society for Biochemistry and Molecular Biology, Inc.",
year = "2015",
month = feb,
day = "6",
doi = "10.1074/jbc.M114.602789",
language = "English",
volume = "290",
pages = "3519--28",
journal = "The Journal of Biological Chemistry",
issn = "0021-9258",
publisher = "American Society for Biochemistry and Molecular Biology, Inc.",
number = "6",
}