Increased nuchal translucency thickness and risk of neurodevelopmental disorders

S G Hellmuth; L H Pedersen; C B Miltoft; O B Petersen; S Kjaergaard; C Ekelund; A Tabor

doi:10.1002/uog.15961

Increased nuchal translucency thickness and risk of neurodevelopmental disorders

S G Hellmuth, L H Pedersen, C B Miltoft, O B Petersen, S Kjaergaard, C Ekelund, A Tabor

12 Citations (Scopus)

Abstract

Objective: To investigate the association between fetal nuchal translucency (NT) thickness and neurodevelopmental disorders in euploid children. Methods: This study included 222 505 euploid children who had undergone routine first-trimester screening during fetal life. Children were divided according to prenatal NT into three groups: NT < 95^th percentile (n = 217 103 (97.6%)); NT 95^th–99^th percentile (n = 4760 (2.1%)); and NT > 99^th percentile (n = 642 (0.3%)). All children were followed-up to a mean age of 4.4 years. Information on diagnoses of intellectual disability, autism spectrum disorders (ASD), cerebral palsy, epilepsy and febrile seizures was obtained from national patient registries. Results: There was no excess risk of neurodevelopmental disorders among euploid children with first-trimester NT 95^th–99^th percentile. For children with NT > 99^th percentile, there were increased risks of intellectual disability (odds ratio (OR), 6.16 (95% CI, 1.51–25.0), 0.31%) and ASD (OR, 2.48 (95% CI, 1.02–5.99), 0.78%) compared with children with NT < 95^th percentile (incidence of 0.05% for intellectual disability and 0.32% for ASD), however, there was no detected increase in the risk of cerebral palsy (OR, 1.91 (95% CI, 0.61–5.95), 0.47%), epilepsy (OR, 1.51 (95% CI, 0.63–3.66), 0.78%) or febrile seizures (OR, 0.72 (95% CI, 0.44–1.16), 2.65%). Conclusions: In a large unselected cohort of euploid children, there was no increased risk of neurodevelopmental disorders among those with a first-trimester NT 95^th–99^th percentile. Among euploid children with first-trimester NT > 99^th percentile, there were increased risks of intellectual disability and ASD, but the absolute risk was reassuringly low (< 1%).

Original language	English
Journal	Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology
Volume	49
Issue number	5
Pages (from-to)	592-598
Number of pages	7
ISSN	0960-7692
DOIs	https://doi.org/10.1002/uog.15961
Publication status	Published - May 2017

Keywords

Adult
Child, Preschool
Chromosome Aberrations
Denmark
Female
Follow-Up Studies
Humans
Infant
Male
Neurodevelopmental Disorders
Nuchal Translucency Measurement
Pregnancy
Pregnancy Outcome
Pregnancy Trimester, First
Registries
Risk Factors
Journal Article

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Hellmuth, S. G., Pedersen, L. H., Miltoft, C. B., Petersen, O. B., Kjaergaard, S., Ekelund, C., & Tabor, A. (2017). Increased nuchal translucency thickness and risk of neurodevelopmental disorders. Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology, 49(5), 592-598. https://doi.org/10.1002/uog.15961

Increased nuchal translucency thickness and risk of neurodevelopmental disorders. / Hellmuth, S G; Pedersen, L H; Miltoft, C B et al.

In: Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology, Vol. 49, No. 5, 05.2017, p. 592-598.

Research output: Contribution to journal › Journal article › Research › peer-review

Hellmuth, SG, Pedersen, LH, Miltoft, CB, Petersen, OB, Kjaergaard, S, Ekelund, C & Tabor, A 2017, 'Increased nuchal translucency thickness and risk of neurodevelopmental disorders', Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology, vol. 49, no. 5, pp. 592-598. https://doi.org/10.1002/uog.15961

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title = "Increased nuchal translucency thickness and risk of neurodevelopmental disorders",

abstract = "Objective: To investigate the association between fetal nuchal translucency (NT) thickness and neurodevelopmental disorders in euploid children. Methods: This study included 222 505 euploid children who had undergone routine first-trimester screening during fetal life. Children were divided according to prenatal NT into three groups: NT < 95th percentile (n = 217 103 (97.6%)); NT 95th–99th percentile (n = 4760 (2.1%)); and NT > 99th percentile (n = 642 (0.3%)). All children were followed-up to a mean age of 4.4 years. Information on diagnoses of intellectual disability, autism spectrum disorders (ASD), cerebral palsy, epilepsy and febrile seizures was obtained from national patient registries. Results: There was no excess risk of neurodevelopmental disorders among euploid children with first-trimester NT 95th–99th percentile. For children with NT > 99th percentile, there were increased risks of intellectual disability (odds ratio (OR), 6.16 (95% CI, 1.51–25.0), 0.31%) and ASD (OR, 2.48 (95% CI, 1.02–5.99), 0.78%) compared with children with NT < 95th percentile (incidence of 0.05% for intellectual disability and 0.32% for ASD), however, there was no detected increase in the risk of cerebral palsy (OR, 1.91 (95% CI, 0.61–5.95), 0.47%), epilepsy (OR, 1.51 (95% CI, 0.63–3.66), 0.78%) or febrile seizures (OR, 0.72 (95% CI, 0.44–1.16), 2.65%). Conclusions: In a large unselected cohort of euploid children, there was no increased risk of neurodevelopmental disorders among those with a first-trimester NT 95th–99th percentile. Among euploid children with first-trimester NT > 99th percentile, there were increased risks of intellectual disability and ASD, but the absolute risk was reassuringly low (< 1%).",

keywords = "Adult, Child, Preschool, Chromosome Aberrations, Denmark, Female, Follow-Up Studies, Humans, Infant, Male, Neurodevelopmental Disorders, Nuchal Translucency Measurement, Pregnancy, Pregnancy Outcome, Pregnancy Trimester, First, Registries, Risk Factors, Journal Article",

author = "Hellmuth, {S G} and Pedersen, {L H} and Miltoft, {C B} and Petersen, {O B} and S Kjaergaard and C Ekelund and A Tabor",

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T1 - Increased nuchal translucency thickness and risk of neurodevelopmental disorders

AU - Hellmuth, S G

AU - Pedersen, L H

AU - Miltoft, C B

AU - Petersen, O B

AU - Kjaergaard, S

AU - Ekelund, C

AU - Tabor, A

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N2 - Objective: To investigate the association between fetal nuchal translucency (NT) thickness and neurodevelopmental disorders in euploid children. Methods: This study included 222 505 euploid children who had undergone routine first-trimester screening during fetal life. Children were divided according to prenatal NT into three groups: NT < 95th percentile (n = 217 103 (97.6%)); NT 95th–99th percentile (n = 4760 (2.1%)); and NT > 99th percentile (n = 642 (0.3%)). All children were followed-up to a mean age of 4.4 years. Information on diagnoses of intellectual disability, autism spectrum disorders (ASD), cerebral palsy, epilepsy and febrile seizures was obtained from national patient registries. Results: There was no excess risk of neurodevelopmental disorders among euploid children with first-trimester NT 95th–99th percentile. For children with NT > 99th percentile, there were increased risks of intellectual disability (odds ratio (OR), 6.16 (95% CI, 1.51–25.0), 0.31%) and ASD (OR, 2.48 (95% CI, 1.02–5.99), 0.78%) compared with children with NT < 95th percentile (incidence of 0.05% for intellectual disability and 0.32% for ASD), however, there was no detected increase in the risk of cerebral palsy (OR, 1.91 (95% CI, 0.61–5.95), 0.47%), epilepsy (OR, 1.51 (95% CI, 0.63–3.66), 0.78%) or febrile seizures (OR, 0.72 (95% CI, 0.44–1.16), 2.65%). Conclusions: In a large unselected cohort of euploid children, there was no increased risk of neurodevelopmental disorders among those with a first-trimester NT 95th–99th percentile. Among euploid children with first-trimester NT > 99th percentile, there were increased risks of intellectual disability and ASD, but the absolute risk was reassuringly low (< 1%).

AB - Objective: To investigate the association between fetal nuchal translucency (NT) thickness and neurodevelopmental disorders in euploid children. Methods: This study included 222 505 euploid children who had undergone routine first-trimester screening during fetal life. Children were divided according to prenatal NT into three groups: NT < 95th percentile (n = 217 103 (97.6%)); NT 95th–99th percentile (n = 4760 (2.1%)); and NT > 99th percentile (n = 642 (0.3%)). All children were followed-up to a mean age of 4.4 years. Information on diagnoses of intellectual disability, autism spectrum disorders (ASD), cerebral palsy, epilepsy and febrile seizures was obtained from national patient registries. Results: There was no excess risk of neurodevelopmental disorders among euploid children with first-trimester NT 95th–99th percentile. For children with NT > 99th percentile, there were increased risks of intellectual disability (odds ratio (OR), 6.16 (95% CI, 1.51–25.0), 0.31%) and ASD (OR, 2.48 (95% CI, 1.02–5.99), 0.78%) compared with children with NT < 95th percentile (incidence of 0.05% for intellectual disability and 0.32% for ASD), however, there was no detected increase in the risk of cerebral palsy (OR, 1.91 (95% CI, 0.61–5.95), 0.47%), epilepsy (OR, 1.51 (95% CI, 0.63–3.66), 0.78%) or febrile seizures (OR, 0.72 (95% CI, 0.44–1.16), 2.65%). Conclusions: In a large unselected cohort of euploid children, there was no increased risk of neurodevelopmental disorders among those with a first-trimester NT 95th–99th percentile. Among euploid children with first-trimester NT > 99th percentile, there were increased risks of intellectual disability and ASD, but the absolute risk was reassuringly low (< 1%).

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KW - Child, Preschool

KW - Chromosome Aberrations

KW - Denmark

KW - Female

KW - Follow-Up Studies

KW - Humans

KW - Infant

KW - Male

KW - Neurodevelopmental Disorders

KW - Nuchal Translucency Measurement

KW - Pregnancy

KW - Pregnancy Outcome

KW - Pregnancy Trimester, First

KW - Registries

KW - Risk Factors

KW - Journal Article

U2 - 10.1002/uog.15961

DO - 10.1002/uog.15961

M3 - Journal article

C2 - 27183961

SN - 0960-7692

VL - 49

SP - 592

EP - 598

JO - Ultrasound in Obstetrics and Gynecology

JF - Ultrasound in Obstetrics and Gynecology

IS - 5

ER -

Increased nuchal translucency thickness and risk of neurodevelopmental disorders

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