Increased nuchal translucency thickness and risk of neurodevelopmental disorders

TY - JOUR

T1 - Increased nuchal translucency thickness and risk of neurodevelopmental disorders

AU - Hellmuth, S G

AU - Pedersen, L H

AU - Miltoft, C B

AU - Petersen, O B

AU - Kjaergaard, S

AU - Ekelund, C

AU - Tabor, A

N1 - Copyright © 2016 ISUOG. Published by John Wiley & Sons Ltd.

PY - 2017/5

Y1 - 2017/5

N2 - Objective: To investigate the association between fetal nuchal translucency (NT) thickness and neurodevelopmental disorders in euploid children. Methods: This study included 222 505 euploid children who had undergone routine first-trimester screening during fetal life. Children were divided according to prenatal NT into three groups: NT < 95th percentile (n = 217 103 (97.6%)); NT 95th–99th percentile (n = 4760 (2.1%)); and NT > 99th percentile (n = 642 (0.3%)). All children were followed-up to a mean age of 4.4 years. Information on diagnoses of intellectual disability, autism spectrum disorders (ASD), cerebral palsy, epilepsy and febrile seizures was obtained from national patient registries. Results: There was no excess risk of neurodevelopmental disorders among euploid children with first-trimester NT 95th–99th percentile. For children with NT > 99th percentile, there were increased risks of intellectual disability (odds ratio (OR), 6.16 (95% CI, 1.51–25.0), 0.31%) and ASD (OR, 2.48 (95% CI, 1.02–5.99), 0.78%) compared with children with NT < 95th percentile (incidence of 0.05% for intellectual disability and 0.32% for ASD), however, there was no detected increase in the risk of cerebral palsy (OR, 1.91 (95% CI, 0.61–5.95), 0.47%), epilepsy (OR, 1.51 (95% CI, 0.63–3.66), 0.78%) or febrile seizures (OR, 0.72 (95% CI, 0.44–1.16), 2.65%). Conclusions: In a large unselected cohort of euploid children, there was no increased risk of neurodevelopmental disorders among those with a first-trimester NT 95th–99th percentile. Among euploid children with first-trimester NT > 99th percentile, there were increased risks of intellectual disability and ASD, but the absolute risk was reassuringly low (< 1%).

AB - Objective: To investigate the association between fetal nuchal translucency (NT) thickness and neurodevelopmental disorders in euploid children. Methods: This study included 222 505 euploid children who had undergone routine first-trimester screening during fetal life. Children were divided according to prenatal NT into three groups: NT < 95th percentile (n = 217 103 (97.6%)); NT 95th–99th percentile (n = 4760 (2.1%)); and NT > 99th percentile (n = 642 (0.3%)). All children were followed-up to a mean age of 4.4 years. Information on diagnoses of intellectual disability, autism spectrum disorders (ASD), cerebral palsy, epilepsy and febrile seizures was obtained from national patient registries. Results: There was no excess risk of neurodevelopmental disorders among euploid children with first-trimester NT 95th–99th percentile. For children with NT > 99th percentile, there were increased risks of intellectual disability (odds ratio (OR), 6.16 (95% CI, 1.51–25.0), 0.31%) and ASD (OR, 2.48 (95% CI, 1.02–5.99), 0.78%) compared with children with NT < 95th percentile (incidence of 0.05% for intellectual disability and 0.32% for ASD), however, there was no detected increase in the risk of cerebral palsy (OR, 1.91 (95% CI, 0.61–5.95), 0.47%), epilepsy (OR, 1.51 (95% CI, 0.63–3.66), 0.78%) or febrile seizures (OR, 0.72 (95% CI, 0.44–1.16), 2.65%). Conclusions: In a large unselected cohort of euploid children, there was no increased risk of neurodevelopmental disorders among those with a first-trimester NT 95th–99th percentile. Among euploid children with first-trimester NT > 99th percentile, there were increased risks of intellectual disability and ASD, but the absolute risk was reassuringly low (< 1%).

KW - Adult

KW - Child, Preschool

KW - Chromosome Aberrations

KW - Denmark

KW - Female

KW - Follow-Up Studies

KW - Humans

KW - Infant

KW - Male

KW - Neurodevelopmental Disorders

KW - Nuchal Translucency Measurement

KW - Pregnancy

KW - Pregnancy Outcome

KW - Pregnancy Trimester, First

KW - Registries

KW - Risk Factors

KW - Journal Article

U2 - 10.1002/uog.15961

DO - 10.1002/uog.15961

M3 - Journal article

C2 - 27183961

SN - 0960-7692

VL - 49

SP - 592

EP - 598

JO - Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology

JF - Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology

IS - 5

ER -