Increased intrinsic mitochondrial function in humans with mitochondrial haplogroup H

Steen Larsen; Carmen Díez-Sánchez; Rasmus Rabøl; Ignacio Ara; Flemming Dela; Jørn Wulff Helge

doi:10.1016/j.bbabio.2013.10.009

Increased intrinsic mitochondrial function in humans with mitochondrial haplogroup H

Steen Larsen, Carmen Díez-Sánchez, Rasmus Rabøl, Ignacio Ara, Flemming Dela, Jørn Wulff Helge

19 Citations (Scopus)

Abstract

It has been suggested that human mitochondrial variants influence maximal oxygen uptake (VO2max). Whether mitochondrial respiratory capacity per mitochondrion (intrinsic activity) in human skeletal muscle is affected by differences in mitochondrial variants is not known. We recruited 54 males and determined their mitochondrial haplogroup, mitochondrial oxidative phosphorylation capacity (OXPHOS), mitochondrial content (citrate synthase (CS)) and VO2max. Intrinsic mitochondrial function is calculated as mitochondrial OXPHOS capacity divided by mitochondrial content (CS). Haplogroup H showed a 30% higher intrinsic mitochondrial function compared with the other haplo group U. There was no relationship between haplogroups and VO2max. In skeletal muscle from men with mitochondrial haplogroup H, an increased intrinsic mitochondrial function is present.

Original language	English
Journal	Biochimica et Biophysica Acta - Bioenergetics
Volume	1837
Issue number	2
Pages (from-to)	226-31
Number of pages	6
ISSN	0005-2728
DOIs	https://doi.org/10.1016/j.bbabio.2013.10.009
Publication status	Published - Feb 2014

Keywords

Citrate (si)-Synthase
Geography
Haplotypes
Humans
Male
Middle Aged
Mitochondria
Muscle Fibers, Skeletal
Oxidative Phosphorylation
Permeability

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10.1016/j.bbabio.2013.10.009

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title = "Increased intrinsic mitochondrial function in humans with mitochondrial haplogroup H",

abstract = "It has been suggested that human mitochondrial variants influence maximal oxygen uptake (VO2max). Whether mitochondrial respiratory capacity per mitochondrion (intrinsic activity) in human skeletal muscle is affected by differences in mitochondrial variants is not known. We recruited 54 males and determined their mitochondrial haplogroup, mitochondrial oxidative phosphorylation capacity (OXPHOS), mitochondrial content (citrate synthase (CS)) and VO2max. Intrinsic mitochondrial function is calculated as mitochondrial OXPHOS capacity divided by mitochondrial content (CS). Haplogroup H showed a 30% higher intrinsic mitochondrial function compared with the other haplo group U. There was no relationship between haplogroups and VO2max. In skeletal muscle from men with mitochondrial haplogroup H, an increased intrinsic mitochondrial function is present.",

keywords = "Citrate (si)-Synthase, Geography, Haplotypes, Humans, Male, Middle Aged, Mitochondria, Muscle Fibers, Skeletal, Oxidative Phosphorylation, Permeability",

author = "Steen Larsen and Carmen D{\'i}ez-S{\'a}nchez and Rasmus Rab{\o}l and Ignacio Ara and Flemming Dela and Helge, {J{\o}rn Wulff}",

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doi = "10.1016/j.bbabio.2013.10.009",

language = "English",

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TY - JOUR

T1 - Increased intrinsic mitochondrial function in humans with mitochondrial haplogroup H

AU - Larsen, Steen

AU - Díez-Sánchez, Carmen

AU - Rabøl, Rasmus

AU - Ara, Ignacio

AU - Dela, Flemming

AU - Helge, Jørn Wulff

PY - 2014/2

Y1 - 2014/2

N2 - It has been suggested that human mitochondrial variants influence maximal oxygen uptake (VO2max). Whether mitochondrial respiratory capacity per mitochondrion (intrinsic activity) in human skeletal muscle is affected by differences in mitochondrial variants is not known. We recruited 54 males and determined their mitochondrial haplogroup, mitochondrial oxidative phosphorylation capacity (OXPHOS), mitochondrial content (citrate synthase (CS)) and VO2max. Intrinsic mitochondrial function is calculated as mitochondrial OXPHOS capacity divided by mitochondrial content (CS). Haplogroup H showed a 30% higher intrinsic mitochondrial function compared with the other haplo group U. There was no relationship between haplogroups and VO2max. In skeletal muscle from men with mitochondrial haplogroup H, an increased intrinsic mitochondrial function is present.

AB - It has been suggested that human mitochondrial variants influence maximal oxygen uptake (VO2max). Whether mitochondrial respiratory capacity per mitochondrion (intrinsic activity) in human skeletal muscle is affected by differences in mitochondrial variants is not known. We recruited 54 males and determined their mitochondrial haplogroup, mitochondrial oxidative phosphorylation capacity (OXPHOS), mitochondrial content (citrate synthase (CS)) and VO2max. Intrinsic mitochondrial function is calculated as mitochondrial OXPHOS capacity divided by mitochondrial content (CS). Haplogroup H showed a 30% higher intrinsic mitochondrial function compared with the other haplo group U. There was no relationship between haplogroups and VO2max. In skeletal muscle from men with mitochondrial haplogroup H, an increased intrinsic mitochondrial function is present.

KW - Citrate (si)-Synthase

KW - Geography

KW - Haplotypes

KW - Humans

KW - Male

KW - Middle Aged

KW - Mitochondria

KW - Muscle Fibers, Skeletal

KW - Oxidative Phosphorylation

KW - Permeability

U2 - 10.1016/j.bbabio.2013.10.009

DO - 10.1016/j.bbabio.2013.10.009

M3 - Journal article

C2 - 24184346

SN - 0005-2728

VL - 1837

SP - 226

EP - 231

JO - B B A - Bioenergetics

JF - B B A - Bioenergetics

IS - 2

ER -

Increased intrinsic mitochondrial function in humans with mitochondrial haplogroup H

Abstract

Keywords

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