Increased intrinsic mitochondrial function in humans with mitochondrial haplogroup H

TY - JOUR

T1 - Increased intrinsic mitochondrial function in humans with mitochondrial haplogroup H

AU - Larsen, Steen

AU - Díez-Sánchez, Carmen

AU - Rabøl, Rasmus

AU - Ara, Ignacio

AU - Dela, Flemming

AU - Helge, Jørn Wulff

N1 - © 2013.

PY - 2014/2

Y1 - 2014/2

N2 - It has been suggested that human mitochondrial variants influence maximal oxygen uptake (VO2max). Whether mitochondrial respiratory capacity per mitochondrion (intrinsic activity) in human skeletal muscle is affected by differences in mitochondrial variants is not known. We recruited 54 males and determined their mitochondrial haplogroup, mitochondrial oxidative phosphorylation capacity (OXPHOS), mitochondrial content (citrate synthase (CS)) and VO2max. Intrinsic mitochondrial function is calculated as mitochondrial OXPHOS capacity divided by mitochondrial content (CS). Haplogroup H showed a 30% higher intrinsic mitochondrial function compared with the other haplo group U. There was no relationship between haplogroups and VO2max. In skeletal muscle from men with mitochondrial haplogroup H, an increased intrinsic mitochondrial function is present.

AB - It has been suggested that human mitochondrial variants influence maximal oxygen uptake (VO2max). Whether mitochondrial respiratory capacity per mitochondrion (intrinsic activity) in human skeletal muscle is affected by differences in mitochondrial variants is not known. We recruited 54 males and determined their mitochondrial haplogroup, mitochondrial oxidative phosphorylation capacity (OXPHOS), mitochondrial content (citrate synthase (CS)) and VO2max. Intrinsic mitochondrial function is calculated as mitochondrial OXPHOS capacity divided by mitochondrial content (CS). Haplogroup H showed a 30% higher intrinsic mitochondrial function compared with the other haplo group U. There was no relationship between haplogroups and VO2max. In skeletal muscle from men with mitochondrial haplogroup H, an increased intrinsic mitochondrial function is present.

KW - Citrate (si)-Synthase

KW - Geography

KW - Haplotypes

KW - Humans

KW - Male

KW - Middle Aged

KW - Mitochondria

KW - Muscle Fibers, Skeletal

KW - Oxidative Phosphorylation

KW - Permeability

U2 - 10.1016/j.bbabio.2013.10.009

DO - 10.1016/j.bbabio.2013.10.009

M3 - Journal article

C2 - 24184346

SN - 0005-2728

VL - 1837

SP - 226

EP - 231

JO - Biochimica et Biophysica Acta - Bioenergetics

JF - Biochimica et Biophysica Acta - Bioenergetics

IS - 2

ER -