Increased frequency of HLA-DPw2 in pauciarticular onset juvenile chronic arthritis

Niels Ødum; Niels Morling; J Friis; C Heilmann; J J Hyldig-Nielsen; B K Jakobsen; F K Pedersen; P Platz; L P Ryder; A Svejgaard

Increased frequency of HLA-DPw2 in pauciarticular onset juvenile chronic arthritis

Niels Ødum, Niels Morling, J Friis, C Heilmann, J J Hyldig-Nielsen, B K Jakobsen, F K Pedersen, P Platz, L P Ryder, A Svejgaard

45 Citations (Scopus)

Abstract

Thirty-six unrelated Danish patients with pauciarticular Juvenile Chronic Arthritis (PJCA) and 120 controls were typed for HLA-DPw1-w6 and the local specificity CDPHEI with bulk-expanded Primed Lymphocyte Typing (PLT) cells. The frequency of HLA-DPw2 was 52.8% in PJCA patients and 16.7% in controls (relative risk, RR = 4.5; P less than 0.001). The antigens HLA-Dw5 and/or Dw8 were present in 50% of the patients and in 21.3% of the controls (RR = 4.2; p less than 10(-3)). DPw2 was not associated (in linkage disequilibrium) with Dw5/w8 in patients or in controls, and the DP and D associations with PJCA were independent of each other. However, the combined presence of DPw2 and Dw5 and/or Dw8 gave a significantly higher risk of PJCA than each antigen alone indicating interaction of DP and DR gene products. PJCA is the first disease definitely found to be associated with a DP antigen.

Original language	English
Journal	HLA
Volume	28
Issue number	4
Pages (from-to)	245-50
Number of pages	5
ISSN	2059-2302
Publication status	Published - 1986

Cite this

@article{b87b2e40fda311ddb219000ea68e967b,

title = "Increased frequency of HLA-DPw2 in pauciarticular onset juvenile chronic arthritis",

abstract = "Thirty-six unrelated Danish patients with pauciarticular Juvenile Chronic Arthritis (PJCA) and 120 controls were typed for HLA-DPw1-w6 and the local specificity CDPHEI with bulk-expanded Primed Lymphocyte Typing (PLT) cells. The frequency of HLA-DPw2 was 52.8% in PJCA patients and 16.7% in controls (relative risk, RR = 4.5; P less than 0.001). The antigens HLA-Dw5 and/or Dw8 were present in 50% of the patients and in 21.3% of the controls (RR = 4.2; p less than 10(-3)). DPw2 was not associated (in linkage disequilibrium) with Dw5/w8 in patients or in controls, and the DP and D associations with PJCA were independent of each other. However, the combined presence of DPw2 and Dw5 and/or Dw8 gave a significantly higher risk of PJCA than each antigen alone indicating interaction of DP and DR gene products. PJCA is the first disease definitely found to be associated with a DP antigen.",

author = "Niels {\O}dum and Niels Morling and J Friis and C Heilmann and Hyldig-Nielsen, {J J} and Jakobsen, {B K} and Pedersen, {F K} and P Platz and Ryder, {L P} and A Svejgaard",

note = "Keywords: Arthritis, Juvenile Rheumatoid; Child; Child, Preschool; Denmark; Female; HLA-D Antigens; HLA-DP Antigens; HLA-DR Antigens; HLA-DR5 Antigen; Histocompatibility Antigens Class II; Humans; Infant; Male",

year = "1986",

language = "English",

volume = "28",

pages = "245--50",

journal = "HLA",

issn = "2059-2302",

publisher = "Wiley",

number = "4",

}

TY - JOUR

T1 - Increased frequency of HLA-DPw2 in pauciarticular onset juvenile chronic arthritis

AU - Ødum, Niels

AU - Morling, Niels

AU - Friis, J

AU - Heilmann, C

AU - Hyldig-Nielsen, J J

AU - Jakobsen, B K

AU - Pedersen, F K

AU - Platz, P

AU - Ryder, L P

AU - Svejgaard, A

N1 - Keywords: Arthritis, Juvenile Rheumatoid; Child; Child, Preschool; Denmark; Female; HLA-D Antigens; HLA-DP Antigens; HLA-DR Antigens; HLA-DR5 Antigen; Histocompatibility Antigens Class II; Humans; Infant; Male

PY - 1986

Y1 - 1986

N2 - Thirty-six unrelated Danish patients with pauciarticular Juvenile Chronic Arthritis (PJCA) and 120 controls were typed for HLA-DPw1-w6 and the local specificity CDPHEI with bulk-expanded Primed Lymphocyte Typing (PLT) cells. The frequency of HLA-DPw2 was 52.8% in PJCA patients and 16.7% in controls (relative risk, RR = 4.5; P less than 0.001). The antigens HLA-Dw5 and/or Dw8 were present in 50% of the patients and in 21.3% of the controls (RR = 4.2; p less than 10(-3)). DPw2 was not associated (in linkage disequilibrium) with Dw5/w8 in patients or in controls, and the DP and D associations with PJCA were independent of each other. However, the combined presence of DPw2 and Dw5 and/or Dw8 gave a significantly higher risk of PJCA than each antigen alone indicating interaction of DP and DR gene products. PJCA is the first disease definitely found to be associated with a DP antigen.

AB - Thirty-six unrelated Danish patients with pauciarticular Juvenile Chronic Arthritis (PJCA) and 120 controls were typed for HLA-DPw1-w6 and the local specificity CDPHEI with bulk-expanded Primed Lymphocyte Typing (PLT) cells. The frequency of HLA-DPw2 was 52.8% in PJCA patients and 16.7% in controls (relative risk, RR = 4.5; P less than 0.001). The antigens HLA-Dw5 and/or Dw8 were present in 50% of the patients and in 21.3% of the controls (RR = 4.2; p less than 10(-3)). DPw2 was not associated (in linkage disequilibrium) with Dw5/w8 in patients or in controls, and the DP and D associations with PJCA were independent of each other. However, the combined presence of DPw2 and Dw5 and/or Dw8 gave a significantly higher risk of PJCA than each antigen alone indicating interaction of DP and DR gene products. PJCA is the first disease definitely found to be associated with a DP antigen.

M3 - Journal article

C2 - 3492783

SN - 2059-2302

VL - 28

SP - 245

EP - 250

JO - HLA

JF - HLA

IS - 4

ER -

Increased frequency of HLA-DPw2 in pauciarticular onset juvenile chronic arthritis

Abstract

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