Increased blood BDNF in healthy individuals with a family history of depression

Ulla Knorr; Mia H Greisen Søndergaard; Pernille Koefoed; Anders Jørgensen; Maria Faurholt-Jepsen; Maj Vinberg; Lars Vedel Kessing

doi:10.1016/j.psychres.2017.06.057

Increased blood BDNF in healthy individuals with a family history of depression

Ulla Knorr, Mia H Greisen Søndergaard, Pernille Koefoed, Anders Jørgensen, Maria Faurholt-Jepsen, Maj Vinberg, Lars Vedel Kessing

Department of Clinical Medicine

8 Citations (Scopus)

Abstract

The brain-derive neurotrophic factor (BDNF) may play an important role in the course of depression. We aimed to study the associations between peripheral whole blood BDNF levels in healthy individuals with and without a family history of depression. BDNF levels were significantly increased in healthy individuals with (n = 76), compared with healthy individuals without (n = 39) a family history of depression and persisted after adjustment for age and gender differences. Higher BDNF levels were associated with increasing age and seasonality. A family history of depression may contribute to an elevation of peripheral BDNF levels in healthy individuals.

Original language	English
Journal	Psychiatry Research
Volume	256
Pages (from-to)	176-179
ISSN	0165-1781
DOIs	https://doi.org/10.1016/j.psychres.2017.06.057
Publication status	Published - Oct 2017

Access to Document

10.1016/j.psychres.2017.06.057

Cite this

@article{ff1ac0e76deb48db97ca65c9aba94a0a,

title = "Increased blood BDNF in healthy individuals with a family history of depression",

abstract = "The brain-derive neurotrophic factor (BDNF) may play an important role in the course of depression. We aimed to study the associations between peripheral whole blood BDNF levels in healthy individuals with and without a family history of depression. BDNF levels were significantly increased in healthy individuals with (n = 76), compared with healthy individuals without (n = 39) a family history of depression and persisted after adjustment for age and gender differences. Higher BDNF levels were associated with increasing age and seasonality. A family history of depression may contribute to an elevation of peripheral BDNF levels in healthy individuals.",

author = "Ulla Knorr and S{\o}ndergaard, {Mia H Greisen} and Pernille Koefoed and Anders J{\o}rgensen and Maria Faurholt-Jepsen and Maj Vinberg and Kessing, {Lars Vedel}",

year = "2017",

month = oct,

doi = "10.1016/j.psychres.2017.06.057",

language = "English",

volume = "256",

pages = "176--179",

journal = "Psychiatry Research",

issn = "0165-1781",

publisher = "Elsevier Ireland Ltd",

}

TY - JOUR

T1 - Increased blood BDNF in healthy individuals with a family history of depression

AU - Knorr, Ulla

AU - Søndergaard, Mia H Greisen

AU - Koefoed, Pernille

AU - Jørgensen, Anders

AU - Faurholt-Jepsen, Maria

AU - Vinberg, Maj

AU - Kessing, Lars Vedel

PY - 2017/10

Y1 - 2017/10

N2 - The brain-derive neurotrophic factor (BDNF) may play an important role in the course of depression. We aimed to study the associations between peripheral whole blood BDNF levels in healthy individuals with and without a family history of depression. BDNF levels were significantly increased in healthy individuals with (n = 76), compared with healthy individuals without (n = 39) a family history of depression and persisted after adjustment for age and gender differences. Higher BDNF levels were associated with increasing age and seasonality. A family history of depression may contribute to an elevation of peripheral BDNF levels in healthy individuals.

AB - The brain-derive neurotrophic factor (BDNF) may play an important role in the course of depression. We aimed to study the associations between peripheral whole blood BDNF levels in healthy individuals with and without a family history of depression. BDNF levels were significantly increased in healthy individuals with (n = 76), compared with healthy individuals without (n = 39) a family history of depression and persisted after adjustment for age and gender differences. Higher BDNF levels were associated with increasing age and seasonality. A family history of depression may contribute to an elevation of peripheral BDNF levels in healthy individuals.

U2 - 10.1016/j.psychres.2017.06.057

DO - 10.1016/j.psychres.2017.06.057

M3 - Journal article

C2 - 28645077

SN - 0165-1781

VL - 256

SP - 176

EP - 179

JO - Psychiatry Research

JF - Psychiatry Research

ER -

Increased blood BDNF in healthy individuals with a family history of depression

Abstract

Access to Document

Fingerprint

Cite this