Increased blood BDNF in healthy individuals with a family history of depression

TY - JOUR

T1 - Increased blood BDNF in healthy individuals with a family history of depression

AU - Knorr, Ulla

AU - Søndergaard, Mia H Greisen

AU - Koefoed, Pernille

AU - Jørgensen, Anders

AU - Faurholt-Jepsen, Maria

AU - Vinberg, Maj

AU - Kessing, Lars Vedel

N1 - Copyright © 2017 Elsevier B.V. All rights reserved.

PY - 2017/10

Y1 - 2017/10

N2 - The brain-derive neurotrophic factor (BDNF) may play an important role in the course of depression. We aimed to study the associations between peripheral whole blood BDNF levels in healthy individuals with and without a family history of depression. BDNF levels were significantly increased in healthy individuals with (n = 76), compared with healthy individuals without (n = 39) a family history of depression and persisted after adjustment for age and gender differences. Higher BDNF levels were associated with increasing age and seasonality. A family history of depression may contribute to an elevation of peripheral BDNF levels in healthy individuals.

AB - The brain-derive neurotrophic factor (BDNF) may play an important role in the course of depression. We aimed to study the associations between peripheral whole blood BDNF levels in healthy individuals with and without a family history of depression. BDNF levels were significantly increased in healthy individuals with (n = 76), compared with healthy individuals without (n = 39) a family history of depression and persisted after adjustment for age and gender differences. Higher BDNF levels were associated with increasing age and seasonality. A family history of depression may contribute to an elevation of peripheral BDNF levels in healthy individuals.

U2 - 10.1016/j.psychres.2017.06.057

DO - 10.1016/j.psychres.2017.06.057

M3 - Journal article

C2 - 28645077

SN - 0165-1781

VL - 256

SP - 176

EP - 179

JO - Psychiatry Research

JF - Psychiatry Research

ER -