Increased activity of pre-motor network does not change the excitability of motoneurons during protracted scratch initiation

Robertas Guzulaitis; Aidas Alaburda; Jørn Dybkjær Hounsgaard

doi:10.1113/jphysiol.2012.246025

Increased activity of pre-motor network does not change the excitability of motoneurons during protracted scratch initiation

Robertas Guzulaitis, Aidas Alaburda, Jørn Dybkjær Hounsgaard

Eyepath Lab

10 Citations (Scopus)

Abstract

Intrinsic response properties of neurons change during network activity. These changes may reinforce the initiation of particular forms of network activity. If so, the involvement of neurons in particular behaviours in multifunctional networks could be determined by up- or down-regulation of their intrinsic excitability. Here we employed an experimental paradigm of protracted scratch initiation in the integrated carapace-spinal cord preparation of adult turtles (Chrysemys scripta elegans). The protracted initiation of scratch network activity allows us to investigate the excitability of motoneurons and pre-motor network activity in the time interval from the start of sensory stimulation until the onset of scratch activity. Our results suggest that increased activity in the pre-motor network facilitates the onset of scratch episodes but does not change the excitability of motoneurons at the onset of scratching.

Original language	English
Journal	Journal of Physiology
Volume	591
Pages (from-to)	1851-1858
Number of pages	8
ISSN	0022-3751
DOIs	https://doi.org/10.1113/jphysiol.2012.246025
Publication status	Published - Apr 2013

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title = "Increased activity of pre-motor network does not change the excitability of motoneurons during protracted scratch initiation",

abstract = "Intrinsic response properties of neurons change during network activity. These changes may reinforce the initiation of particular forms of network activity. If so, the involvement of neurons in particular behaviours in multifunctional networks could be determined by up- or down-regulation of their intrinsic excitability. Here we employed an experimental paradigm of protracted scratch initiation in the integrated carapace-spinal cord preparation of adult turtles (Chrysemys scripta elegans). The protracted initiation of scratch network activity allows us to investigate the excitability of motoneurons and pre-motor network activity in the time interval from the start of sensory stimulation until the onset of scratch activity. Our results suggest that increased activity in the pre-motor network facilitates the onset of scratch episodes but does not change the excitability of motoneurons at the onset of scratching.",

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T1 - Increased activity of pre-motor network does not change the excitability of motoneurons during protracted scratch initiation

AU - Guzulaitis, Robertas

AU - Alaburda, Aidas

AU - Hounsgaard, Jørn Dybkjær

PY - 2013/4

Y1 - 2013/4

N2 - Intrinsic response properties of neurons change during network activity. These changes may reinforce the initiation of particular forms of network activity. If so, the involvement of neurons in particular behaviours in multifunctional networks could be determined by up- or down-regulation of their intrinsic excitability. Here we employed an experimental paradigm of protracted scratch initiation in the integrated carapace-spinal cord preparation of adult turtles (Chrysemys scripta elegans). The protracted initiation of scratch network activity allows us to investigate the excitability of motoneurons and pre-motor network activity in the time interval from the start of sensory stimulation until the onset of scratch activity. Our results suggest that increased activity in the pre-motor network facilitates the onset of scratch episodes but does not change the excitability of motoneurons at the onset of scratching.

AB - Intrinsic response properties of neurons change during network activity. These changes may reinforce the initiation of particular forms of network activity. If so, the involvement of neurons in particular behaviours in multifunctional networks could be determined by up- or down-regulation of their intrinsic excitability. Here we employed an experimental paradigm of protracted scratch initiation in the integrated carapace-spinal cord preparation of adult turtles (Chrysemys scripta elegans). The protracted initiation of scratch network activity allows us to investigate the excitability of motoneurons and pre-motor network activity in the time interval from the start of sensory stimulation until the onset of scratch activity. Our results suggest that increased activity in the pre-motor network facilitates the onset of scratch episodes but does not change the excitability of motoneurons at the onset of scratching.

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DO - 10.1113/jphysiol.2012.246025

M3 - Journal article

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SP - 1851

EP - 1858

JO - The Journal of Physiology

JF - The Journal of Physiology

ER -

Increased activity of pre-motor network does not change the excitability of motoneurons during protracted scratch initiation

Abstract

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