Increased activity of pre-motor network does not change the excitability of motoneurons during protracted scratch initiation

Robertas Guzulaitis; Aidas Alaburda; Jørn Dybkjær Hounsgaard

doi:10.1113/jphysiol.2012.246025

Increased activity of pre-motor network does not change the excitability of motoneurons during protracted scratch initiation

Robertas Guzulaitis, Aidas Alaburda, Jørn Dybkjær Hounsgaard

Eyepath Lab

10 Citationer (Scopus)

Abstract

Intrinsic response properties of neurons change during network activity. These changes may reinforce the initiation of particular forms of network activity. If so, the involvement of neurons in particular behaviours in multifunctional networks could be determined by up- or down-regulation of their intrinsic excitability. Here we employed an experimental paradigm of protracted scratch initiation in the integrated carapace-spinal cord preparation of adult turtles (Chrysemys scripta elegans). The protracted initiation of scratch network activity allows us to investigate the excitability of motoneurons and pre-motor network activity in the time interval from the start of sensory stimulation until the onset of scratch activity. Our results suggest that increased activity in the pre-motor network facilitates the onset of scratch episodes but does not change the excitability of motoneurons at the onset of scratching.

Originalsprog	Engelsk
Tidsskrift	Journal of Physiology
Vol/bind	591
Sider (fra-til)	1851-1858
Antal sider	8
ISSN	0022-3751
DOI	https://doi.org/10.1113/jphysiol.2012.246025
Status	Udgivet - apr. 2013

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10.1113/jphysiol.2012.246025

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title = "Increased activity of pre-motor network does not change the excitability of motoneurons during protracted scratch initiation",

abstract = "Intrinsic response properties of neurons change during network activity. These changes may reinforce the initiation of particular forms of network activity. If so, the involvement of neurons in particular behaviours in multifunctional networks could be determined by up- or down-regulation of their intrinsic excitability. Here we employed an experimental paradigm of protracted scratch initiation in the integrated carapace-spinal cord preparation of adult turtles (Chrysemys scripta elegans). The protracted initiation of scratch network activity allows us to investigate the excitability of motoneurons and pre-motor network activity in the time interval from the start of sensory stimulation until the onset of scratch activity. Our results suggest that increased activity in the pre-motor network facilitates the onset of scratch episodes but does not change the excitability of motoneurons at the onset of scratching.",

author = "Robertas Guzulaitis and Aidas Alaburda and Hounsgaard, {J{\o}rn Dybkj{\ae}r}",

year = "2013",

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doi = "10.1113/jphysiol.2012.246025",

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T1 - Increased activity of pre-motor network does not change the excitability of motoneurons during protracted scratch initiation

AU - Guzulaitis, Robertas

AU - Alaburda, Aidas

AU - Hounsgaard, Jørn Dybkjær

PY - 2013/4

Y1 - 2013/4

N2 - Intrinsic response properties of neurons change during network activity. These changes may reinforce the initiation of particular forms of network activity. If so, the involvement of neurons in particular behaviours in multifunctional networks could be determined by up- or down-regulation of their intrinsic excitability. Here we employed an experimental paradigm of protracted scratch initiation in the integrated carapace-spinal cord preparation of adult turtles (Chrysemys scripta elegans). The protracted initiation of scratch network activity allows us to investigate the excitability of motoneurons and pre-motor network activity in the time interval from the start of sensory stimulation until the onset of scratch activity. Our results suggest that increased activity in the pre-motor network facilitates the onset of scratch episodes but does not change the excitability of motoneurons at the onset of scratching.

AB - Intrinsic response properties of neurons change during network activity. These changes may reinforce the initiation of particular forms of network activity. If so, the involvement of neurons in particular behaviours in multifunctional networks could be determined by up- or down-regulation of their intrinsic excitability. Here we employed an experimental paradigm of protracted scratch initiation in the integrated carapace-spinal cord preparation of adult turtles (Chrysemys scripta elegans). The protracted initiation of scratch network activity allows us to investigate the excitability of motoneurons and pre-motor network activity in the time interval from the start of sensory stimulation until the onset of scratch activity. Our results suggest that increased activity in the pre-motor network facilitates the onset of scratch episodes but does not change the excitability of motoneurons at the onset of scratching.

U2 - 10.1113/jphysiol.2012.246025

DO - 10.1113/jphysiol.2012.246025

M3 - Journal article

C2 - 23339173

SN - 0022-3751

VL - 591

SP - 1851

EP - 1858

JO - Journal of Physiology

JF - Journal of Physiology

ER -

Increased activity of pre-motor network does not change the excitability of motoneurons during protracted scratch initiation

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