Abstract
This study investigated serum 25-hydroxyvitamin D (25(OH)D) concentrations and circulating regulatory T cells in patients with atopic dermatitis receiving narrow-band ultraviolet B (nbUVB) phototherapy. Thirty adult patients with atopic dermatitis were included. Blood samples were collected at baseline and at weeks 2 and 4 of nbUVB phototherapy. Skin biopsies were taken at baseline and at week 4. Serum 25(OH) D concentrations increased significantly following nbUVB phototherapy (estimate of change from baseline to week 2: 32.00 nmol/l, confidence interval (CI) 20.48–43.52, p < 0.0001, n = 25; and from baseline to week 4: 50.30 nmol/l, CI 37.28–63.33, p < 0.0001, n = 18). This increase was independent of the filaggrin gene loss-of-function mutation status. Flow cytometry showed no significant change in regulatory T cells or cytokine profiles of T cells in blood. Real-time quantitative PCR showed no change in skin cytokine levels. In conclusion, nbUVB phototherapy was associated with increased serum 25(OH)D concentrations, but not changes in circulating regulatory T cells in patients with atopic dermatitis.
| Original language | English |
|---|---|
| Journal | Acta Dermato-Venereologica |
| Volume | 99 |
| Issue number | 2 |
| Pages (from-to) | 139-145 |
| Number of pages | 7 |
| ISSN | 0001-5555 |
| DOIs | |
| Publication status | Published - 2019 |
Keywords
- 25-hydroxyvitamin D
- Atopic dermatitis
- Filaggrin
- NbUVB phototherapy
- Regulatory T cells