In vivo Imaging of Sarcoptes scabiei Infestation Using Optical Coherence Tomography

Christina Alette Banzhaf; Lotte Themstrup; Hans Christian Ring; Julia Welzel; Mette Mogensen; Gregor Borut Ernst Jemec

doi:10.1159/000352066

In vivo Imaging of Sarcoptes scabiei Infestation Using Optical Coherence Tomography

Christina Alette Banzhaf, Lotte Themstrup, Hans Christian Ring, Julia Welzel, Mette Mogensen, Gregor Borut Ernst Jemec

Department of Clinical Medicine

18 Citations (Scopus)

Abstract

BACKGROUND: Sarcoptes scabiei can be visualized with different imaging tools. Optical coherence tomography (OCT) may have the potential to describe the changes in skin morphology due to scabies infestation and visualize the parasite.

METHODS: Five patients from the Departments of Dermatology, Augsburg, Germany, and Roskilde, Denmark, were OCT scanned (VivoSight(®); Michelson Diagnostics Ltd., UK). Mites were identified by epiluminescence and light microscopy to confirm the diagnosis.

RESULTS: OCT identified S. scabiei mites in all patients in vivo. Mites and burrows were visualized, and some detail on burrow content was provided.

CONCLUSION: OCT can visualize S. scabiei mites in vivo, suggesting that it may be used to study the biology of the mites in vivo and provide early assessment of scabicide therapy. OCT is able to visualize structures in the skin with an 8-μm resolution. Therefore, this technology could potentially allow rapid, non-invasive, in vivo diagnosis and analysis of infestations.

Original language	English
Journal	Case Reports in Dermatology
Volume	5
Issue number	2
Pages (from-to)	156-62
Number of pages	7
ISSN	1662-6567
DOIs	https://doi.org/10.1159/000352066
Publication status	Published - May 2013

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title = "In vivo Imaging of Sarcoptes scabiei Infestation Using Optical Coherence Tomography",

abstract = "BACKGROUND: Sarcoptes scabiei can be visualized with different imaging tools. Optical coherence tomography (OCT) may have the potential to describe the changes in skin morphology due to scabies infestation and visualize the parasite.METHODS: Five patients from the Departments of Dermatology, Augsburg, Germany, and Roskilde, Denmark, were OCT scanned (VivoSight({\textregistered}); Michelson Diagnostics Ltd., UK). Mites were identified by epiluminescence and light microscopy to confirm the diagnosis.RESULTS: OCT identified S. scabiei mites in all patients in vivo. Mites and burrows were visualized, and some detail on burrow content was provided.CONCLUSION: OCT can visualize S. scabiei mites in vivo, suggesting that it may be used to study the biology of the mites in vivo and provide early assessment of scabicide therapy. OCT is able to visualize structures in the skin with an 8-μm resolution. Therefore, this technology could potentially allow rapid, non-invasive, in vivo diagnosis and analysis of infestations.",

author = "Banzhaf, {Christina Alette} and Lotte Themstrup and Ring, {Hans Christian} and Julia Welzel and Mette Mogensen and Jemec, {Gregor Borut Ernst}",

year = "2013",

month = may,

doi = "10.1159/000352066",

language = "English",

volume = "5",

pages = "156--62",

journal = "Case Reports in Dermatology",

issn = "1662-6567",

publisher = "S Karger AG",

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T1 - In vivo Imaging of Sarcoptes scabiei Infestation Using Optical Coherence Tomography

AU - Banzhaf, Christina Alette

AU - Themstrup, Lotte

AU - Ring, Hans Christian

AU - Welzel, Julia

AU - Mogensen, Mette

AU - Jemec, Gregor Borut Ernst

PY - 2013/5

Y1 - 2013/5

N2 - BACKGROUND: Sarcoptes scabiei can be visualized with different imaging tools. Optical coherence tomography (OCT) may have the potential to describe the changes in skin morphology due to scabies infestation and visualize the parasite.METHODS: Five patients from the Departments of Dermatology, Augsburg, Germany, and Roskilde, Denmark, were OCT scanned (VivoSight(®); Michelson Diagnostics Ltd., UK). Mites were identified by epiluminescence and light microscopy to confirm the diagnosis.RESULTS: OCT identified S. scabiei mites in all patients in vivo. Mites and burrows were visualized, and some detail on burrow content was provided.CONCLUSION: OCT can visualize S. scabiei mites in vivo, suggesting that it may be used to study the biology of the mites in vivo and provide early assessment of scabicide therapy. OCT is able to visualize structures in the skin with an 8-μm resolution. Therefore, this technology could potentially allow rapid, non-invasive, in vivo diagnosis and analysis of infestations.

AB - BACKGROUND: Sarcoptes scabiei can be visualized with different imaging tools. Optical coherence tomography (OCT) may have the potential to describe the changes in skin morphology due to scabies infestation and visualize the parasite.METHODS: Five patients from the Departments of Dermatology, Augsburg, Germany, and Roskilde, Denmark, were OCT scanned (VivoSight(®); Michelson Diagnostics Ltd., UK). Mites were identified by epiluminescence and light microscopy to confirm the diagnosis.RESULTS: OCT identified S. scabiei mites in all patients in vivo. Mites and burrows were visualized, and some detail on burrow content was provided.CONCLUSION: OCT can visualize S. scabiei mites in vivo, suggesting that it may be used to study the biology of the mites in vivo and provide early assessment of scabicide therapy. OCT is able to visualize structures in the skin with an 8-μm resolution. Therefore, this technology could potentially allow rapid, non-invasive, in vivo diagnosis and analysis of infestations.

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DO - 10.1159/000352066

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SN - 1662-6567

VL - 5

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EP - 162

JO - Case Reports in Dermatology

JF - Case Reports in Dermatology

IS - 2

ER -

In vivo Imaging of Sarcoptes scabiei Infestation Using Optical Coherence Tomography

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