In vivo Imaging of Sarcoptes scabiei Infestation Using Optical Coherence Tomography

Christina Alette Banzhaf; Lotte Themstrup; Hans Christian Ring; Julia Welzel; Mette Mogensen; Gregor Borut Ernst Jemec

doi:10.1159/000352066

In vivo Imaging of Sarcoptes scabiei Infestation Using Optical Coherence Tomography

Christina Alette Banzhaf, Lotte Themstrup, Hans Christian Ring, Julia Welzel, Mette Mogensen, Gregor Borut Ernst Jemec

Institut for Klinisk Medicin

18 Citationer (Scopus)

Abstract

BACKGROUND: Sarcoptes scabiei can be visualized with different imaging tools. Optical coherence tomography (OCT) may have the potential to describe the changes in skin morphology due to scabies infestation and visualize the parasite.

METHODS: Five patients from the Departments of Dermatology, Augsburg, Germany, and Roskilde, Denmark, were OCT scanned (VivoSight(®); Michelson Diagnostics Ltd., UK). Mites were identified by epiluminescence and light microscopy to confirm the diagnosis.

RESULTS: OCT identified S. scabiei mites in all patients in vivo. Mites and burrows were visualized, and some detail on burrow content was provided.

CONCLUSION: OCT can visualize S. scabiei mites in vivo, suggesting that it may be used to study the biology of the mites in vivo and provide early assessment of scabicide therapy. OCT is able to visualize structures in the skin with an 8-μm resolution. Therefore, this technology could potentially allow rapid, non-invasive, in vivo diagnosis and analysis of infestations.

Originalsprog	Engelsk
Tidsskrift	Case Reports in Dermatology
Vol/bind	5
Udgave nummer	2
Sider (fra-til)	156-62
Antal sider	7
ISSN	1662-6567
DOI	https://doi.org/10.1159/000352066
Status	Udgivet - maj 2013

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10.1159/000352066

Citationsformater

@article{aa4ccee4e1bc4e6f869437647d526b0a,

title = "In vivo Imaging of Sarcoptes scabiei Infestation Using Optical Coherence Tomography",

abstract = "BACKGROUND: Sarcoptes scabiei can be visualized with different imaging tools. Optical coherence tomography (OCT) may have the potential to describe the changes in skin morphology due to scabies infestation and visualize the parasite.METHODS: Five patients from the Departments of Dermatology, Augsburg, Germany, and Roskilde, Denmark, were OCT scanned (VivoSight({\textregistered}); Michelson Diagnostics Ltd., UK). Mites were identified by epiluminescence and light microscopy to confirm the diagnosis.RESULTS: OCT identified S. scabiei mites in all patients in vivo. Mites and burrows were visualized, and some detail on burrow content was provided.CONCLUSION: OCT can visualize S. scabiei mites in vivo, suggesting that it may be used to study the biology of the mites in vivo and provide early assessment of scabicide therapy. OCT is able to visualize structures in the skin with an 8-μm resolution. Therefore, this technology could potentially allow rapid, non-invasive, in vivo diagnosis and analysis of infestations.",

author = "Banzhaf, {Christina Alette} and Lotte Themstrup and Ring, {Hans Christian} and Julia Welzel and Mette Mogensen and Jemec, {Gregor Borut Ernst}",

year = "2013",

month = may,

doi = "10.1159/000352066",

language = "English",

volume = "5",

pages = "156--62",

journal = "Case Reports in Dermatology",

issn = "1662-6567",

publisher = "S Karger AG",

number = "2",

}

TY - JOUR

T1 - In vivo Imaging of Sarcoptes scabiei Infestation Using Optical Coherence Tomography

AU - Banzhaf, Christina Alette

AU - Themstrup, Lotte

AU - Ring, Hans Christian

AU - Welzel, Julia

AU - Mogensen, Mette

AU - Jemec, Gregor Borut Ernst

PY - 2013/5

Y1 - 2013/5

N2 - BACKGROUND: Sarcoptes scabiei can be visualized with different imaging tools. Optical coherence tomography (OCT) may have the potential to describe the changes in skin morphology due to scabies infestation and visualize the parasite.METHODS: Five patients from the Departments of Dermatology, Augsburg, Germany, and Roskilde, Denmark, were OCT scanned (VivoSight(®); Michelson Diagnostics Ltd., UK). Mites were identified by epiluminescence and light microscopy to confirm the diagnosis.RESULTS: OCT identified S. scabiei mites in all patients in vivo. Mites and burrows were visualized, and some detail on burrow content was provided.CONCLUSION: OCT can visualize S. scabiei mites in vivo, suggesting that it may be used to study the biology of the mites in vivo and provide early assessment of scabicide therapy. OCT is able to visualize structures in the skin with an 8-μm resolution. Therefore, this technology could potentially allow rapid, non-invasive, in vivo diagnosis and analysis of infestations.

AB - BACKGROUND: Sarcoptes scabiei can be visualized with different imaging tools. Optical coherence tomography (OCT) may have the potential to describe the changes in skin morphology due to scabies infestation and visualize the parasite.METHODS: Five patients from the Departments of Dermatology, Augsburg, Germany, and Roskilde, Denmark, were OCT scanned (VivoSight(®); Michelson Diagnostics Ltd., UK). Mites were identified by epiluminescence and light microscopy to confirm the diagnosis.RESULTS: OCT identified S. scabiei mites in all patients in vivo. Mites and burrows were visualized, and some detail on burrow content was provided.CONCLUSION: OCT can visualize S. scabiei mites in vivo, suggesting that it may be used to study the biology of the mites in vivo and provide early assessment of scabicide therapy. OCT is able to visualize structures in the skin with an 8-μm resolution. Therefore, this technology could potentially allow rapid, non-invasive, in vivo diagnosis and analysis of infestations.

U2 - 10.1159/000352066

DO - 10.1159/000352066

M3 - Journal article

C2 - 23874291

SN - 1662-6567

VL - 5

SP - 156

EP - 162

JO - Case Reports in Dermatology

JF - Case Reports in Dermatology

IS - 2

ER -

In vivo Imaging of Sarcoptes scabiei Infestation Using Optical Coherence Tomography

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