In vitro screening and evaluation of synbiotics

Maria Lena Martinsson; Maria Wiese; Dennis Sandris Nielsen; Gabriella Christina van Zanten

doi:10.1016/B978-0-12-802189-7.00033-2

In vitro screening and evaluation of synbiotics

Maria Lena Martinsson, Maria Wiese, Dennis Sandris Nielsen, Gabriella Christina van Zanten

Food Microbiology, Gut Health, and Fermentation

3 Citations (Scopus)

Abstract

Synbiotics, the combination of probiotics and prebiotics, have many proposed beneficial effects. While human intervention studies are the "gold standard,° in vitro models are more simple, cheap, and noninvasive for assessment of synbiotic effects in the gastrointestinal tract (GIT). Numerous in vitro models simulating upper and lower parts of the GIT exist. They have been used for assessment of synbiotics with regard to survival of probiotics and effects on gut microbiota, while intestinal cell lines have been applied to investigate effects of synbiotics on adhesion, barrier function, and genotoxicity resistance. However, the models and methods used are highly variable with regard to a number of parameters, hampering comparability. Future models, simulating the entire GIT, will facilitate a more complete in vitro evaluation of synbiotics, and standardized guidelines should help increase comparability across different studies.

Original language	English
Title of host publication	Probiotics, prebiotics and synbiotics : bioactive foods in health promotion
Editors	Ronald Ross Watson, Victor R. Preedy
Number of pages	10
Publisher	Academic Press
Publication date	2016
Pages	477-486
Chapter	33
ISBN (Electronic)	978-0-12-802189-7
DOIs	https://doi.org/10.1016/B978-0-12-802189-7.00033-2
Publication status	Published - 2016

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In vitro screening and evaluation of synbiotics. / Martinsson, Maria Lena; Wiese, Maria; Nielsen, Dennis Sandris et al.

Probiotics, prebiotics and synbiotics: bioactive foods in health promotion. ed. / Ronald Ross Watson; Victor R. Preedy. Academic Press, 2016. p. 477-486.

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

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In vitro screening and evaluation of synbiotics

Abstract

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