In vitro digestion models to evaluate lipid based drug delivery systems; present status and current trends

TY - JOUR

T1 - In vitro digestion models to evaluate lipid based drug delivery systems; present status and current trends

AU - Berthelsen, Ragna

AU - Klitgaard, Mette

AU - Rades, Thomas

AU - Müllertz, Anette

N1 - Copyright © 2019 Elsevier B.V. All rights reserved.

PY - 2019/3/1

Y1 - 2019/3/1

N2 - During the past two decades, a range of in vitro models simulating the digestion processes occurring in the stomach and small intestine have been developed to characterize lipid based drug delivery systems (LbDDSs). This review describes the presently existing range of in vitro digestion models and their use in the field of oral drug delivery. The models are evaluated in terms of their suitability to assess LbDDSs, and their ability to produce in vitro - in vivo correlations (IVIVCs). While the pH-stat lipolysis model is by far the most commonly utilized in vitro digestion model in relation to characterizing LbDDSs, a series of recent studies have shown a lack of IVIVCs limiting its future use. Presently, no single in vitro digestion model exists which is able to predict the in vivo performance of various LbDDSs. However, recent research has shown the potential of combined digestion-permeation models as well as species specific digestion models.

AB - During the past two decades, a range of in vitro models simulating the digestion processes occurring in the stomach and small intestine have been developed to characterize lipid based drug delivery systems (LbDDSs). This review describes the presently existing range of in vitro digestion models and their use in the field of oral drug delivery. The models are evaluated in terms of their suitability to assess LbDDSs, and their ability to produce in vitro - in vivo correlations (IVIVCs). While the pH-stat lipolysis model is by far the most commonly utilized in vitro digestion model in relation to characterizing LbDDSs, a series of recent studies have shown a lack of IVIVCs limiting its future use. Presently, no single in vitro digestion model exists which is able to predict the in vivo performance of various LbDDSs. However, recent research has shown the potential of combined digestion-permeation models as well as species specific digestion models.

U2 - 10.1016/j.addr.2019.06.010

DO - 10.1016/j.addr.2019.06.010

M3 - Review

C2 - 31265861

SN - 0169-409X

VL - 142

SP - 35

EP - 49

JO - Advanced Drug Delivery Reviews

JF - Advanced Drug Delivery Reviews

ER -