TY - JOUR
T1 - Improved large-scale synthesis and characterization of small and medium generation PAMAM dendrimers
AU - Ficker, Mario
AU - Paolucci, Valentina
AU - Christensen, Jørn Bolstad
PY - 2017
Y1 - 2017
N2 - Dendrimers are promising polymers for biomedical applications; however, most dendrimer formulations have failed to move from laboratory science to upscaled products for preclinical testing or GMP production. This publications reports on an improved large-scale PAMAM dendrimer synthesis that is suitable to manufacture large amounts of highly pure and monodisperse dendrimers of generations G0-G5. Furthermore, an extended analytical guideline how to characterize PAMAM dendrimers with NMR, HPLC, SEC-MALS, ESI, MALDI, UV-vis, fluorescence, and IR spectroscopy is provided.
AB - Dendrimers are promising polymers for biomedical applications; however, most dendrimer formulations have failed to move from laboratory science to upscaled products for preclinical testing or GMP production. This publications reports on an improved large-scale PAMAM dendrimer synthesis that is suitable to manufacture large amounts of highly pure and monodisperse dendrimers of generations G0-G5. Furthermore, an extended analytical guideline how to characterize PAMAM dendrimers with NMR, HPLC, SEC-MALS, ESI, MALDI, UV-vis, fluorescence, and IR spectroscopy is provided.
U2 - 10.1139/cjc-2017-0108
DO - 10.1139/cjc-2017-0108
M3 - Journal article
SN - 0008-4042
VL - 95
SP - 954
EP - 964
JO - Canadian Journal of Chemistry
JF - Canadian Journal of Chemistry
IS - 9
ER -