Improved large-scale synthesis and characterization of small and medium generation PAMAM dendrimers

TY - JOUR

T1 - Improved large-scale synthesis and characterization of small and medium generation PAMAM dendrimers

AU - Ficker, Mario

AU - Paolucci, Valentina

AU - Christensen, Jørn Bolstad

PY - 2017

Y1 - 2017

N2 - Dendrimers are promising polymers for biomedical applications; however, most dendrimer formulations have failed to move from laboratory science to upscaled products for preclinical testing or GMP production. This publications reports on an improved large-scale PAMAM dendrimer synthesis that is suitable to manufacture large amounts of highly pure and monodisperse dendrimers of generations G0-G5. Furthermore, an extended analytical guideline how to characterize PAMAM dendrimers with NMR, HPLC, SEC-MALS, ESI, MALDI, UV-vis, fluorescence, and IR spectroscopy is provided.

AB - Dendrimers are promising polymers for biomedical applications; however, most dendrimer formulations have failed to move from laboratory science to upscaled products for preclinical testing or GMP production. This publications reports on an improved large-scale PAMAM dendrimer synthesis that is suitable to manufacture large amounts of highly pure and monodisperse dendrimers of generations G0-G5. Furthermore, an extended analytical guideline how to characterize PAMAM dendrimers with NMR, HPLC, SEC-MALS, ESI, MALDI, UV-vis, fluorescence, and IR spectroscopy is provided.

U2 - 10.1139/cjc-2017-0108

DO - 10.1139/cjc-2017-0108

M3 - Journal article

SN - 0008-4042

VL - 95

SP - 954

EP - 964

JO - Canadian Journal of Chemistry

JF - Canadian Journal of Chemistry

IS - 9

ER -