Impact of H1N1 Influenza Vaccination on Child Morbidity in Guinea-Bissau

Olga Bengård Hansen; Amabelia Rodrigues; Cesario Martins; Andreas Rieckmann; Christine Stabell Benn; Peter Aaby; Ane Bærent Fisker

doi:10.1093/tropej/fmy075

Impact of H1N1 Influenza Vaccination on Child Morbidity in Guinea-Bissau

Olga Bengård Hansen^*, Amabelia Rodrigues, Cesario Martins, Andreas Rieckmann, Christine Stabell Benn, Peter Aaby, Ane Bærent Fisker

^*Corresponding author for this work

Abstract

Background: In addition to vaccines' specific effects, vaccines may have non-specific effects (NSEs) altering the susceptibility to unrelated infections. Non-live vaccines have been associated with negative NSEs. In 2010, a campaign with the non-live H1N1-influenza vaccine targeted children 6-59 months in Guinea-Bissau. Methods: Bandim Health Project runs a health and demographic surveillance system site in Guinea-Bissau. Using a Cox proportional hazards model, we compared all-cause consultation rates after vs. before the campaign, stratified by participation status. Results: Among 10 290 children eligible for the campaign, 60% had participated, 18% had not and for 22% no information was obtained. After the H1N1 campaign, the consultation rates tended to decline less for participants [HR = 0.80 (95% confidence interval, CI: 0.75; 0.85)] than for non-participants [HR = 0.68 (95% CI: 0.58; 0.79)], p = 0.06 for same effect. Conclusion: The decline in the vaccinated group may have been smaller than the decline in the non-vaccinated group consistent with H1N1-vaccine increasing susceptibility to unrelated infections.

Original language	English
Journal	Journal of Tropical Pediatrics
Volume	65
Issue number	5
Pages (from-to)	446-456
Number of pages	11
ISSN	0142-6338
DOIs	https://doi.org/10.1093/tropej/fmy075
Publication status	Published - 3 Oct 2019

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@article{d1e7ad36610f4592bf2f2d396e7ce510,

title = "Impact of H1N1 Influenza Vaccination on Child Morbidity in Guinea-Bissau",

abstract = "Background: In addition to vaccines' specific effects, vaccines may have non-specific effects (NSEs) altering the susceptibility to unrelated infections. Non-live vaccines have been associated with negative NSEs. In 2010, a campaign with the non-live H1N1-influenza vaccine targeted children 6-59 months in Guinea-Bissau. Methods: Bandim Health Project runs a health and demographic surveillance system site in Guinea-Bissau. Using a Cox proportional hazards model, we compared all-cause consultation rates after vs. before the campaign, stratified by participation status. Results: Among 10 290 children eligible for the campaign, 60% had participated, 18% had not and for 22% no information was obtained. After the H1N1 campaign, the consultation rates tended to decline less for participants [HR = 0.80 (95% confidence interval, CI: 0.75; 0.85)] than for non-participants [HR = 0.68 (95% CI: 0.58; 0.79)], p = 0.06 for same effect. Conclusion: The decline in the vaccinated group may have been smaller than the decline in the non-vaccinated group consistent with H1N1-vaccine increasing susceptibility to unrelated infections.",

author = "Hansen, {Olga Beng{\aa}rd} and Amabelia Rodrigues and Cesario Martins and Andreas Rieckmann and Benn, {Christine Stabell} and Peter Aaby and Fisker, {Ane B{\ae}rent}",

note = "A correction has been published: Journal of Tropical Pediatrics, fmz009, https://doi.org/10.1093/tropej/fmz009 ",

year = "2019",

month = oct,

day = "3",

doi = "10.1093/tropej/fmy075",

language = "English",

volume = "65",

pages = "446--456",

journal = "Journal of Tropical Pediatrics",

issn = "0142-6338",

publisher = "Oxford University Press",

number = "5",

}

TY - JOUR

T1 - Impact of H1N1 Influenza Vaccination on Child Morbidity in Guinea-Bissau

AU - Hansen, Olga Bengård

AU - Rodrigues, Amabelia

AU - Martins, Cesario

AU - Rieckmann, Andreas

AU - Benn, Christine Stabell

AU - Aaby, Peter

AU - Fisker, Ane Bærent

N1 - A correction has been published: Journal of Tropical Pediatrics, fmz009, https://doi.org/10.1093/tropej/fmz009

PY - 2019/10/3

Y1 - 2019/10/3

N2 - Background: In addition to vaccines' specific effects, vaccines may have non-specific effects (NSEs) altering the susceptibility to unrelated infections. Non-live vaccines have been associated with negative NSEs. In 2010, a campaign with the non-live H1N1-influenza vaccine targeted children 6-59 months in Guinea-Bissau. Methods: Bandim Health Project runs a health and demographic surveillance system site in Guinea-Bissau. Using a Cox proportional hazards model, we compared all-cause consultation rates after vs. before the campaign, stratified by participation status. Results: Among 10 290 children eligible for the campaign, 60% had participated, 18% had not and for 22% no information was obtained. After the H1N1 campaign, the consultation rates tended to decline less for participants [HR = 0.80 (95% confidence interval, CI: 0.75; 0.85)] than for non-participants [HR = 0.68 (95% CI: 0.58; 0.79)], p = 0.06 for same effect. Conclusion: The decline in the vaccinated group may have been smaller than the decline in the non-vaccinated group consistent with H1N1-vaccine increasing susceptibility to unrelated infections.

AB - Background: In addition to vaccines' specific effects, vaccines may have non-specific effects (NSEs) altering the susceptibility to unrelated infections. Non-live vaccines have been associated with negative NSEs. In 2010, a campaign with the non-live H1N1-influenza vaccine targeted children 6-59 months in Guinea-Bissau. Methods: Bandim Health Project runs a health and demographic surveillance system site in Guinea-Bissau. Using a Cox proportional hazards model, we compared all-cause consultation rates after vs. before the campaign, stratified by participation status. Results: Among 10 290 children eligible for the campaign, 60% had participated, 18% had not and for 22% no information was obtained. After the H1N1 campaign, the consultation rates tended to decline less for participants [HR = 0.80 (95% confidence interval, CI: 0.75; 0.85)] than for non-participants [HR = 0.68 (95% CI: 0.58; 0.79)], p = 0.06 for same effect. Conclusion: The decline in the vaccinated group may have been smaller than the decline in the non-vaccinated group consistent with H1N1-vaccine increasing susceptibility to unrelated infections.

U2 - 10.1093/tropej/fmy075

DO - 10.1093/tropej/fmy075

M3 - Journal article

C2 - 30590828

SN - 0142-6338

VL - 65

SP - 446

EP - 456

JO - Journal of Tropical Pediatrics

JF - Journal of Tropical Pediatrics

IS - 5

ER -

Impact of H1N1 Influenza Vaccination on Child Morbidity in Guinea-Bissau

Abstract

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