TY - JOUR
T1 - Impact of H1N1 Influenza Vaccination on Child Morbidity in Guinea-Bissau
AU - Hansen, Olga Bengård
AU - Rodrigues, Amabelia
AU - Martins, Cesario
AU - Rieckmann, Andreas
AU - Benn, Christine Stabell
AU - Aaby, Peter
AU - Fisker, Ane Bærent
N1 - A correction has been published:
Journal of Tropical Pediatrics, fmz009, https://doi.org/10.1093/tropej/fmz009
PY - 2019/10/3
Y1 - 2019/10/3
N2 - Background: In addition to vaccines' specific effects, vaccines may have non-specific effects (NSEs) altering the susceptibility to unrelated infections. Non-live vaccines have been associated with negative NSEs. In 2010, a campaign with the non-live H1N1-influenza vaccine targeted children 6-59 months in Guinea-Bissau. Methods: Bandim Health Project runs a health and demographic surveillance system site in Guinea-Bissau. Using a Cox proportional hazards model, we compared all-cause consultation rates after vs. before the campaign, stratified by participation status. Results: Among 10 290 children eligible for the campaign, 60% had participated, 18% had not and for 22% no information was obtained. After the H1N1 campaign, the consultation rates tended to decline less for participants [HR = 0.80 (95% confidence interval, CI: 0.75; 0.85)] than for non-participants [HR = 0.68 (95% CI: 0.58; 0.79)], p = 0.06 for same effect. Conclusion: The decline in the vaccinated group may have been smaller than the decline in the non-vaccinated group consistent with H1N1-vaccine increasing susceptibility to unrelated infections.
AB - Background: In addition to vaccines' specific effects, vaccines may have non-specific effects (NSEs) altering the susceptibility to unrelated infections. Non-live vaccines have been associated with negative NSEs. In 2010, a campaign with the non-live H1N1-influenza vaccine targeted children 6-59 months in Guinea-Bissau. Methods: Bandim Health Project runs a health and demographic surveillance system site in Guinea-Bissau. Using a Cox proportional hazards model, we compared all-cause consultation rates after vs. before the campaign, stratified by participation status. Results: Among 10 290 children eligible for the campaign, 60% had participated, 18% had not and for 22% no information was obtained. After the H1N1 campaign, the consultation rates tended to decline less for participants [HR = 0.80 (95% confidence interval, CI: 0.75; 0.85)] than for non-participants [HR = 0.68 (95% CI: 0.58; 0.79)], p = 0.06 for same effect. Conclusion: The decline in the vaccinated group may have been smaller than the decline in the non-vaccinated group consistent with H1N1-vaccine increasing susceptibility to unrelated infections.
U2 - 10.1093/tropej/fmy075
DO - 10.1093/tropej/fmy075
M3 - Journal article
C2 - 30590828
SN - 0142-6338
VL - 65
SP - 446
EP - 456
JO - Journal of Tropical Pediatrics
JF - Journal of Tropical Pediatrics
IS - 5
ER -
