Immunologic manifestations of autophagy

Vojo Deretic; Tomonori Kimura; Graham Timmins; Pope Moseley; Santosh Chauhan; Michael Mandell

doi:10.1172/jci73945

Immunologic manifestations of autophagy

Vojo Deretic, Tomonori Kimura, Graham Timmins, Pope Moseley, Santosh Chauhan, Michael Mandell

Disease Systems Biology Program

100 Citations (Scopus)

Abstract

The broad immunologic roles of autophagy span innate and adaptive immunity and are often manifested in inflammatory diseases. The immune effects of autophagy partially overlap with its roles in metabolism and cytoplasmic quality control but typically expand further afield to encompass unique immunologic adaptations. One of the best-appreciated manifestations of autophagy is protection against microbial invasion, but this is by no means limited to direct elimination of intracellular pathogens and includes a stratified array of nearly all principal immunologic processes. This Review summarizes the broad immunologic roles of autophagy. Furthermore, it uses the autophagic control of Mycobacterium tuberculosis as a paradigm to illustrate the breadth and complexity of the immune effects of autophagy.

Original language	English
Journal	The Journal of Clinical Investigation
Volume	125
Issue number	1
Pages (from-to)	75-84
Number of pages	10
ISSN	0021-9738
DOIs	https://doi.org/10.1172/jci73945
Publication status	Published - 2 Jan 2015

Keywords

Adaptive Immunity
Animals
Autophagy
Host-Pathogen Interactions
Humans
Immunity, Innate
Inflammation/pathology
Mycobacterium tuberculosis/immunology
Phagocytosis
Tuberculosis/immunology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Immunologic manifestations of autophagy",

abstract = "The broad immunologic roles of autophagy span innate and adaptive immunity and are often manifested in inflammatory diseases. The immune effects of autophagy partially overlap with its roles in metabolism and cytoplasmic quality control but typically expand further afield to encompass unique immunologic adaptations. One of the best-appreciated manifestations of autophagy is protection against microbial invasion, but this is by no means limited to direct elimination of intracellular pathogens and includes a stratified array of nearly all principal immunologic processes. This Review summarizes the broad immunologic roles of autophagy. Furthermore, it uses the autophagic control of Mycobacterium tuberculosis as a paradigm to illustrate the breadth and complexity of the immune effects of autophagy. ",

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AU - Deretic, Vojo

AU - Kimura, Tomonori

AU - Timmins, Graham

AU - Moseley, Pope

AU - Chauhan, Santosh

AU - Mandell, Michael

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N2 - The broad immunologic roles of autophagy span innate and adaptive immunity and are often manifested in inflammatory diseases. The immune effects of autophagy partially overlap with its roles in metabolism and cytoplasmic quality control but typically expand further afield to encompass unique immunologic adaptations. One of the best-appreciated manifestations of autophagy is protection against microbial invasion, but this is by no means limited to direct elimination of intracellular pathogens and includes a stratified array of nearly all principal immunologic processes. This Review summarizes the broad immunologic roles of autophagy. Furthermore, it uses the autophagic control of Mycobacterium tuberculosis as a paradigm to illustrate the breadth and complexity of the immune effects of autophagy.

AB - The broad immunologic roles of autophagy span innate and adaptive immunity and are often manifested in inflammatory diseases. The immune effects of autophagy partially overlap with its roles in metabolism and cytoplasmic quality control but typically expand further afield to encompass unique immunologic adaptations. One of the best-appreciated manifestations of autophagy is protection against microbial invasion, but this is by no means limited to direct elimination of intracellular pathogens and includes a stratified array of nearly all principal immunologic processes. This Review summarizes the broad immunologic roles of autophagy. Furthermore, it uses the autophagic control of Mycobacterium tuberculosis as a paradigm to illustrate the breadth and complexity of the immune effects of autophagy.

KW - Adaptive Immunity

KW - Animals

KW - Autophagy

KW - Host-Pathogen Interactions

KW - Humans

KW - Immunity, Innate

KW - Inflammation/pathology

KW - Mycobacterium tuberculosis/immunology

KW - Phagocytosis

KW - Tuberculosis/immunology

U2 - 10.1172/jci73945

DO - 10.1172/jci73945

M3 - Review

C2 - 25654553

SN - 0021-9738

VL - 125

SP - 75

EP - 84

JO - Journal of Clinical Investigation

JF - Journal of Clinical Investigation

IS - 1

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Immunologic manifestations of autophagy

Abstract

Keywords

UN SDGs

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